Effects of propranolol and metoprolol on haemodynamic and respiratory indices and on perceived exertion during exercise in hypertensive patients. [PDF]
, 1979 C L van Herwaarden +3 more
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Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira +14 more
wiley +1 more source
Molecular Oncology, EarlyView.This real‐world study of ROS1+ NSCLC highlights fusion diversity, treatment outcomes with crizotinib and lorlatinib, and in vitro experiments with resistance mechanisms. G2032R drives strong resistance to ROS1‐targeted TKIs, especially lorlatinib. Fusion partner location does not affect overall survival to crizotinib or lorlatinib. Findings support the
Fenneke Zwierenga +8 more
wiley +1 more source
The Use of the Blood Lactate Curve to Develop Training Intensity Guidelines for the Sports of Track and Field and Cross-Country [PDF]
, 2012 Int J Exerc Sci 5(2) : 148-159, 2012. The purpose of this study was to develop and field test a standardized system of training intensity guidelines for the sport of track and field/cross country, modeled after the standardized system of training ...
Belcher, Chris P., Pemberton, Cynthia L
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Understanding and measuring mechanical signals in the tumor stroma
FEBS Open Bio, EarlyView.This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz +3 more
wiley +1 more source
The effects of man-marking on work intensity in small-sided soccer games [PDF]
, 2012 The aim of this study was to examine the effect of manipulating defensive rules: with and without man-marking (MM and NMM) on exercise intensity in 3 vs. 3 small-sided games (SSGs). Twelve adolescent soccer players (age: 16.2 ± 0.7 years; body mass: 55.7
Carling, C. +5 more
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FEBS Open Bio, EarlyView.The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik +3 more
wiley +1 more source
The use of heart rate indices and subjective questionnaires in the determination of fatigue in motor-manual tree felling and delimbing operations in New Zealand exotic plantation forests : a thesis presented in partial fulfilment of the requirements for the degree of Master of Business Studies in Ergonomics at Massey University [PDF]
, 1996 This study assessed the use of heart rate indices and subjective questionnaires in the determination of fatigue in motor-manual tree felling operations in New Zealand exotic plantation forests. The research design consisted of a causal study utilising an
Kirk, Patrick Michael
core
FEBS Open Bio, EarlyView.Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran +3 more
wiley +1 more source