Results 71 to 80 of about 8,711,500 (297)

Job Stress Ditinjau Dari Perceived Organizational Support Pada Perawat di Rumah Sakit Umum Elpi Al Azis Rantauprapat

Jurnal Penelitian Pendidikan, Psikologi dan Kesehatan
Penelitian ini bertujuan untuk mengeksplorasi hubungan antara Job Stress dan Perceived Organizational Support pada perawat di RSU Elpi Al Azis Rantauprapat.
Sri Hartini, Mulia Risnanda, Ika Kristin Br Manurung, Nicholas Montoya, Rio Fernando Panjaitan   +4 more
doaj   +1 more source

Beyond social exchange: Collectivism’s moderating role in the relationship between perceived organizational support and organizational citizenship behaviour

, 2015
Perceived organizational support plays an important role in the social exchange relationship between the employee and the organization. We propose that individual differences in collectivism affect the extent to which employee–organization relationships ...
van Knippenberg, Daan, van Prooijen, JW, Sleebos, E, van Prooijen, J.W.; id_orcid, Sleebos, E., van Prooijen, J.W., van Knippenberg, Daan; id_orcid, van Knippenberg, D., Sleebos, E.; id_orcid   +8 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Organizational Commitment: Do Workplace Practices Matter? [PDF]

Using nationally-representative linked employer-employee data for Britain this paper considers whether employers are able to influence the organizational commitment (OC) of their employees through the practices they deploy.
Michael White, Alex Bryson
core  

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Perceived Organizational Support and Perceived Role Clarity as Predictors of Organizational Commitment

Cyprus Turkish Journal of Psychiatry and Psychology
The present study investigates the effect of perceived organizational support (POS) and perceived role clarity on the organizational commitment of IT professionals in India. As the labor market faces intense competition and work arrangements reorganize, it becomes critical to understand the psychological bond employees develop with their institutions ...
Vaishali Choudhary, Shadab Ahamad Ansari
openaire   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

HUBUNGAN ANTARA PERCEIVED ORGANIZATIONAL SUPPORT DENGAN WORK-LIFE BALANCE PADA KARYAWAN PT. BPR KUSUMA SUMBING DI JAWA TENGAH

Jurnal Empati, 2019
Penelitian ini bertujuan untuk mengetahui hubungan antara perceived organizational support dengan work-life balance pada karyawan PT. BPR Kusuma Sumbing di Jawa Tengah.
Krisdianti Adinda Puspitasari, Ika Zenita Ratnaningsih   +1 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source