Results 51 to 60 of about 8,711,500 (297)

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

The effect of perceived organizational support on the transfer of training outcomes to the workplace

open access: yes, 2012
Transfer of training refers to the consistent application of the knowledge, skills and attitudes that are learned from training to the workplace. The success of transfer of training is influenced by many factors including the work environment.
Boyle, Steven   +2 more
core   +1 more source

The Effect of Deviant Workplace Behavior on Job Performance: The Mediating Role of Organizational Shame and Moderating Role of Perceived Organizational Support

open access: yes, 2023
It is not uncommon for employees to engage in deviant workplace behavior. Several studies have been conducted on its antecedent variables and negative effects on the organization and its members.
Xin Tian, Ying Guo
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Gender and the Perceived Equity - Perceived Organizational Support Link in Egypt [PDF]

open access: yesEurasian Journal of Business and Economics, 2017
This study aimed at examining the relationships between perceived internal and external salary equities as independent variables, and perceived organizational support (POS) as a dependent variable among Egyptian employees.
Mohamed Hossameldin KHALIFA, Rana ZAKI
doaj   +1 more source

A Review of Perceived Organizational Support

open access: yesDEStech Transactions on Economics, Business and Management, 2018
This paper is a review of perceived organizational support (POS), which is firstly proposed by Eisenberger based on the social exchange theory and the reciprocity principle. Through a detailed review of the theoretical basis, definition, antecedents and consequences of POS, it is recommended that there is still space for research in this field, and ...
openaire   +2 more sources

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The Impact of Organizational Climate and Perceived Organizational Support on Organizational Commitment: The Mediating Role of Job Satisfaction

open access: yesIndonesian Interdisciplinary Journal of Sharia Economics
This research aims to analyze the influence of organizational climate, perceived organizational support, and job satisfaction on Organizational Commitment. The analysis uses Structural Equation Modeling with the Partial Least Square (PLS) approach.
Minti Hari   +3 more
doaj   +1 more source

Perceived Organizational Support Dengan Employee Engagement Pada Karyawan

open access: yesPsikoislamedia, 2020
Penelitian ini bertujuan untuk mengetahui hubungan antara perceived organizational support dengan employee engagement pada karyawan. Hipotesis  yang diajukan adalah ada hubungan positif antara perceived organizational support dengan employee engagement ...
Muhammad Agung Alkasim   +1 more
doaj   +1 more source

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