Results 101 to 110 of about 2,699,721 (304)

Latent profiles of youth social support: a study on variations and their impact on self-esteem

Frontiers in Psychology
IntroductionThe current significant suicide rate reflects the urgency of addressing mental health problems among young people. At the same time, social support and self-esteem are key factors affecting young people’s mental health and suicide risk ...
Jingxian Yu, Yuqin Guo, Yongqi Liang, Huan Peng, Na Li, Weisheng Gu, Hanjiao Liu   +6 more
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Perceived stress and its relationship with perceived social support in women undergoing chemotherapy for reproductive system cancers

حیات, 2018
Background & Aim: Women with cancer face many stresses. Social support can facilitate coping skills and improve active coping strategies. The purpose of this study was to assess perceived stress and its relationship with perceived social support in women
Fahimeh Sehhati Shafaei, Mojgan Mirghafourvand, Mina Hoseinzadeh   +2 more
doaj  

Inequality and happiness: When perceived social mobility and economic reality do not match [PDF]

In this paper, we revisit the association between happiness and inequality. We argue that the interaction between the perceived and the actual fairness of the income generation process affects this association.
Bjornskov, Christian, Dreher, Axel, Fischer, Justina AV, Schnellenbach, Jan   +3 more
core   +1 more source

Perceived social support, depression, and perceived stress in university students

Archives of Advances in Biosciences, 2013
      Psychological disorders are universally common problems. Social support contributes much to the health of individuals. Focusing upon social support and upon vicissitudes of life can help prevent the depression-induced disorders. The present paper investigated the relationship between perceived social support, depression and perceived stress in ...
Ramezankhani, Ali, Gharlipour, Zabihollah, Babaei Heydarabadi, Akbar, Tavassoli, Elahe, Motalebi, Masoud, Barekati, Hasan, Gilasi, Hamid Reza, Kermani Ranjbar, Tahereh, Moosavi, Seyed Akbar   +8 more
openaire   +1 more source