Results 111 to 120 of about 19,600,371 (313)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Author Correction: Effect of 5-weeks participation in The Daily Mile on cognitive function, physical fitness, and body composition in children

Scientific Reports, 2022
Karah J. Dring, Lorna M. Hatch, Ryan A. Williams, John G. Morris, Caroline Sunderland, Mary E. Nevill, Simon B. Cooper   +6 more
doaj   +1 more source

The role of osteoprotegerin (OPG) in exercise-induced skeletal muscle adaptation

Translational Exercise Biomedicine
The purpose of this narrative review is to offer an updated perspective on the current research on the glycoprotein Osteoprotegerin (OPG), including its potential therapeutic impact and mechanisms of action, and interaction with bone and muscle tissues.
Owens Aaron, Dos Santos Livia, Brook Matthew, Hunt John, Piasecki Mathew, Piasecki Jessica   +5 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Identifying Early Signals From Emerging Public Health Events Using Natural Language Processing

Interdisciplinary Perspectives on Infectious Diseases
Timely detection of emerging public health threats is challenging because the surveillance infrastructure is not yet tuned to the emerging threat. We attempt to identify three nonspecific early signals that might be common across emerging events: public ...
Kelly S. Peterson, Christian Dalton, Andrea Kalvesmaki, JoAnn Vuong, Colton Gordon, Senthil Nachimuthu, Mary Jo Pugh, Makoto M. Jones   +7 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Changes in the ideal body shape associated with adolescent rowing‐ergometry performance following a 6‐week training intervention: New scaling insights using three‐dimensional allometry

European Journal of Sport Science
Scaling, to remove the effects of body size, is an important methodological approach for enabling an equitable comparison of performance differences between individuals who vary in anthropometric characteristics.
Alan M. Nevill, Grace W. M. Walters, Karah J. Dring, Benjamin A. Nevill, Simon B. Cooper, John G. Morris   +5 more
doaj   +1 more source