Results 111 to 120 of about 1,685,327 (341)

Survey study of changes in total caloric and protein intake across the menopause transition: a preliminary analysis

Journal of the International Society of Sports Nutrition
Background The menopausal transition is characterized by hormonal shifts, particularly a decline in estrogen, which is associated with increased fat mass and reduced lean body mass.
Valeria V. Silva Ramirez, Anna Oelmann, John Holtje, Landon Shannahan, Gretchen Shelton, Nam Nguyen, Stacy T. Sims, Jacey A. Greece, Laura Pyott, Gabrielle Lyon, Michael J. Ormsbee, Bill I. Campbell   +11 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Textured mat influence on muscle activity and balance strategies for chronic ankle instability

Human Movement
Purpose To evaluate the impact of textured mats on muscle activation and postural sway to enhance neuromuscular control and balance strategies in the rehabilitation of chronic ankle instability (CAI).
Nanthiphak Konphet, Akkradate Siriphorn
doaj   +1 more source

Enhancing GenMC’s Usability and Performance

AbstractGenMC is a state-of-the-art stateless model checker that can verify safety properties of concurrent C/C++ programs under a wide range of memory consistency models, such as SC, TSO, RC11, and IMM.In this paper, we improve the performance and usability of GenMC: we provide a probabilistic estimate of the expected verification cost, we automate ...
Michalis Kokologiannakis, Rupak Majumdar, Viktor Vafeiadis   +2 more
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Barriers, facilitators, and factors influencing the perceived feasibility of family-based physical activity: The role of socioeconomic status

Advanced Exercise and Health Science
The facilitators and barriers to family-based physical activity, child and parent perceptions of the factors influencing their perceived feasibility of family-based physical activity, and the impact of socioeconomic status on these, are relatively ...
Scarlett M. Fountain, Simon B. Cooper, Ryan A. Williams, Caroline Sunderland, Ali Bowes, Karah J. Dring   +5 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source