Results 131 to 140 of about 18,560,364 (298)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Quality Matters overview

open access: yes, 2016
The presentation provides overview of the Quality Matters services and best practices.We do not provide public access to this presentation.
Quality Matters
core  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

Linking internal service quality and casino dealer performance

open access: yes, 2017
The job responsibilities of a casino card dealer can encompass everything from dealing cards to entertaining customers. Whilst technical cards dealing is a fundamental part of their job requirement, the nontechnical service performance of engaging with ...
Catherine Prentice, Prentice, Catherine
core   +1 more source

The effectiveness of the Halliwick concept hydrotherapy and Bobath (Neurodevelopmental Treatment-NDT) in the treatment of children with cerebral palsy–A randomised controlled trial

open access: yesBrain Disorders
Background: Children with cerebral palsy (CP) often face challenges in motor function, balance, and daily activities. While land-based therapies such as the Bobath concept are widely used, complementary water-based therapies, including the Halliwick ...
Konstantinos Chandolias   +7 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

Do Incumbents Improve Service Quality in Response to Entry? Evidence from Airlines’ On-Time Performance [PDF]

open access: yes
We examine if and how incumbent firms respond to entry, and entry threats, using non-price modes of competition. Our analysis focuses on service quality within the airline industry.
Daniel H. Simon, Jeffrey T. Prince
core  

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