Cholesterol promotes interaction of the protein CLIC1 with phospholipid monolayers at the air–water interface [PDF]
, 2016 © 2016 by the authors; licensee MDPI, Basel, Switzerland. CLIC1 is a Chloride Intracellular Ion Channel protein that exists either in a soluble state in the cytoplasm or as a membrane bound protein. Members of the CLIC family are largely soluble proteins
Holt, SA +3 more
core +1 more source
VirulenceClostridium perfringens type A causes gas gangrene, which involves muscle infection. Both alpha toxin (PLC), encoded by the plc gene, and perfringolysin O (PFO), encoded by the pfoA gene, are important when type A strains cause gas gangrene in a mouse ...
Jihong Li +2 more
doaj +1 more source
Q&A: What are exosomes, exactly? [PDF]
, 2016 Exosomes are extracellular vesicles first described as such 30 years ago and since implicated in cell–cell communication and the transmission of disease states, and explored as a means of drug discovery.
Edgar, James R
core +1 more source
Selective Cholesterol Dynamics between Lipoproteins and Caveolae/Lipid Rafts [PDF]
, 2007 Although low-density lipoprotein (LDL) receptor-mediated cholesterol uptake through clathrin-coated pits is now well understood, the molecular details and organizing principles for selective cholesterol uptake/efflux (reverse cholesterol transport, RCT ...
Atshaves, Barbara P. +9 more
core +2 more sources
The arginine deiminase pathway in the wine lactic acid bacteria Lactobacillus hilgardii X1B: structural and functional study of the arcABC genes [PDF]
, 2002 The genes implicated in the catabolism of the amino acid arginine by Lactobacillus hilgardiiX1Bwere investigated to assess the potential for formation of ethyl carbamate precursors in wine. L.
Hengesbach, S. +3 more
core +1 more source
A biotinylated perfringolysin O derivative: A new probe for detection of cell surface cholesterol
Biochimica et Biophysica Acta (BBA) - Biomembranes, 1997 theta-Toxin is a cholesterol-binding, pore-forming cytolysin of Clostridium perfringens. To detect cell surface cholesterol, we prepared a theta-toxin derivative, BC theta by biotinylation of a protease-nicked theta-toxin, which has the same binding affinity for cholesterol as theta-toxin without cytolytic activity.
Iwamoto, Machiko +5 more
openaire +2 more sources
Immunogenic and neutralization efficacy of recombinant perfringolysin O of Clostridium perfringens and its C-terminal receptor-binding domain in a murine model. [PDF]
Immunol Res, 2022 Singh A, Rawat P, Choudhury D, Dixit A.
europepmc +1 more source
Structure of the poly-C9 component of the complement membrane attack complex [PDF]
, 2016 The membrane attack complex (MAC)/perforin-like protein complement component 9 (C9) is the major component of the MAC, a multi-protein complex that forms pores in the membrane of target pathogens.
Conroy, P.J. +13 more
core +1 more source
ウエルシュ菌におけるパーフリンゴリジン-O産生の分子機構 [PDF]
, 1996 Thesis (Ph.D. in Medical Sciences)--University of Tsukuba, (A), no.
Ba-Thein William
core
The FASEB Journal, 2006 Perfringolysin O (PFO) is a pore‐forming toxin secreted by Clostridium perfringens. Upon encountering a cholesterol‐containing membrane, the toxin oligomerizes and spontaneously inserts into the bilayer to form a large pore (diameter ~300 Å).
Alejandro P Heuck +2 more
openaire +1 more source