Results 111 to 120 of about 2,525 (205)

Preclinical evaluation of VAX-IP, a novel bacterial minicell-based biopharmaceutical for nonmuscle invasive bladder cancer

Molecular Therapy: Oncolytics, 2016
The development of new therapies that can prevent recurrence and progression of nonmuscle invasive bladder cancer remains an unmet clinical need. The continued cost of monitoring and treatment of recurrent disease, along with its high prevalence and ...
Shingo Tsuji, Xuguang Chen, Bryan Hancock, Veronica Hernandez, Barbara Visentin, Katherine Reil, Roger Sabbadini, Matthew Giacalone, WT Godbey   +8 more
doaj   +1 more source

How interaction of perfringolysin O with membranes is controlled by sterol structure, lipid structure, and physiological low pH: insights into the origin of perfringolysin O-lipid raft interaction.

The Journal of biological chemistry, 2008
Perfringolysin O (PFO) is a sterol-dependent, pore-forming cytolysin. To understand the molecular basis of PFO membrane interaction, we studied its dependence upon sterol and lipid structure and aqueous environment. PFO interacted with diverse sterols, although binding was affected by double bond location in the sterol rings, sterol side chain ...
Lindsay D, Nelson, Arthur E, Johnson, Erwin, London   +2 more
openaire   +2 more sources

Evidence for hypoxia‐induced dysregulated cholesterol homeostasis in preeclampsia: Insights into the mechanisms from human placental cells and tissues

The FASEB Journal, Volume 38, Issue 2, 31 January 2024.
This study provides a comprehensive overview of disrupted cholesterol homeostasis pathways in the pregnancy disorder preeclampsia. Additionally, we investigated a cell model designed to simulate this disorder by inducing continuous and intermittent hypoxic episodes.
Barbara Fuenzalida, Maria Jose Yañez, Martin Mueller, Hiten D. Mistry, Andrea Leiva, Christiane Albrecht   +5 more
wiley   +1 more source

An Autopsy Case of Fulminant Systemic Infection of Clostridium perfringens With a Diverse Role of Toxins in a Healthy Patient

Case Reports in Pathology, Volume 2024, Issue 1, 2024.
We herein report an autopsy case of a fulminant Clostridium perfringens (C. perfringens or Welch bacilli) infection in a healthy adult. A 72‐year‐old, immunocompetent man visited the emergency department with lower back pain, and blood test revealed hemolytic attack.
Ayano Osamura, Hiromi Onizuka, Kenta Masui, Kumiko Murakami, Tomoko Yamamoto, Yoji Nagashima, Munekazu Takeda, Atsushi Kurata, Tanja Batinac   +8 more
wiley   +1 more source

A Nonpolycationic Fully Proteinaceous Multiagent System for Potent Targeted Delivery of siRNA

Molecular Therapy: Nucleic Acids, 2014
Protein-based methods of targeted short-interfering RNA (siRNA) delivery have the potential to solve some of the problems faced by nanoparticle-based methods, such as poor pharmacokinetics and biodistribution, low tumor penetration, and polydispersity ...
David V Liu, Nicole J Yang, K Dane Wittrup   +2 more
doaj   +1 more source

Identification of the additional mitochondrial liabilities of 2-hydroxyflutamide when compared to its parent compound, flutamide in HepG2 cells [PDF]

, 2016
The androgen receptor antagonist, flutamide, is strongly associated with idiosyncratic drug-induced liver injury (DILI). Following administration, flutamide undergoes extensive first-pass metabolism to its primary metabolite, 2-hydroxyflutamide ...
Alfirevic, A, Ball, AL, Chadwick, AE, Kamalian, L, Lyon, JJ   +4 more
core   +1 more source

Three-dimensional architecture and biogenesis of membrane structures associated with hepatitis C virus replication [PDF]

, 2012
All positive strand RNA viruses are known to replicate their genomes in close association with intracellular membranes. In case of the hepatitis C virus (HCV), a member of the family Flaviviridae, infected cells contain accumulations of vesicles forming ...
Antony, Claude, Bartenschlager, Ralf, Chiramel, Abhilash, Chlanda, Petr, Habermann, Anja, Haselman, Uta, Hoppe, Simone, Kallis, Stephanie, Krijnse-Locker, Jacomine, Lee, Ji-Young, Merz, Andreas, Romero-Brey, Inés, Santarella-Mellwig, Rachel, Walther, Paul   +13 more
core   +3 more sources

Immunization with the C-domain of α-toxin prevents lethal infection, localizes tissue injury, and promotes host response to challenge with Clostridium perfringens [PDF]

, 2013
© 2004 by the Infectious Diseases Society of America. All rights reserved.Clostridium perfringens gas gangrene is characterized by rapid tissue destruction, impaired host response, and, often, death. Phospholipase C (α-toxin) is the virulence factor most
Bayer, Clifford R., Bryant, Amy E., Hayes-Schroer, Susan M., Jepson, Marie, Stevens, Dennis L., Titball, Richard W.   +5 more
core   +1 more source

Passive administration of monoclonal antibodies to Anthrolysin O prolong survival in mice lethally infected with Bacillus anthracis [PDF]

, 2008
Background Bacillus anthracis has two major virulence factors: a tripartite toxin that produces lethal and edema toxins and a polyglutamic acid capsule. A recent report suggested that a toxin belonging to the cholesterol dependant cytolysin (CDC) family,
Antonio Nakouzi, Johanna Rivera, Richard F Rest, Arturo Casadevall   +3 more
core   +1 more source

LTP-triggered cholesterol redistribution activates Cdc42 and drives AMPA receptor synaptic delivery [PDF]

, 2015
Neurotransmitter receptor trafficking during synaptic plasticity requires the concerted action of multiple signaling pathways and the protein transport machinery. However, little is known about the contribution of lipid metabolism during these processes.
Abe, Anna Brachet, Aoki, Arendt, Björkhem, Bligh, Bliss, Boehm, Brouwers, Brouwers, Brown, Caldeira, Carlos G. Dotti, Christian, Dart, Deutsch, Dietschy, Ehrengruber, Ernest Palomer, Fessler, Frank, Gamba, Gerges, Goslin, Granger, Gähwiler, Hansen, Hao, Hao, Hayashi, Hering, Hou, Huganir, Hölttä-Vuori, Hölttä-Vuori, J. Bernd Helms, Jaksits, Jos F. Brouwers, José A. Esteban, Kennedy, Kim, Klein, Kopec, Kotti, Lange, Ledesma, Ledesma, Linetti, Linsenbardt, Lippincott-Schwartz, Liu, Malinow, Malinow, Mans, Marks, Martin, Martin, Martin, Mayor, Mercer, Monyer, Murakoshi, Ohtani, Otmakhov, Park, Passafaro, Pfrieger, Renner, Rodriguez-Fraticelli, Rouser, Shepherd, Shi, Shimada, Simons, Smith, Sodero, Sodero, Sodero, Stephanie Norwood, Suzuki, Ullrich, Valenza, Valenza, Xie, Zidovetzki   +84 more
core   +1 more source