Results 101 to 110 of about 2,525 (205)
International Journal of Medical Microbiology, 2020 Clostridium perfringens is the causative agent of human clostridial myonecrosis; the major toxins involved in this disease are α-toxin and perfringolysin O.
Jackie K. Cheung +7 more
doaj +1 more source
Functional analysis of the VirSR phosphorelay from Clostridium perfringens. [PDF]
PLoS ONE, 2009 Toxin production in Clostridium perfringens is controlled by the VirSR two-component signal transduction system, which comprises the VirS sensor histidine kinase and the VirR response regulator.
Jackie K Cheung +3 more
doaj +1 more source
Bacterial pore-forming toxins: The (w)hole story? [PDF]
, 2018 .: Pore-forming toxins (PFTs) are the most common class of bacterial protein toxins and constitute important bacterial virulence factors. The mode of action of PFT is starting to be better understood.
Bischofberger, M. +4 more
core
Dynasore - not just a dynamin inhibitor [PDF]
, 2015 Dynamin is a GTPase protein that is essential for membrane fission during clathrin-mediated endocytosis in eukaryotic cells. Dynasore is a GTPase inhibitor that rapidly and reversibly inhibits dynamin activity, which prevents endocytosis.
James Cronin, Martin Sheldon
core +1 more source
European Journal of Immunology, Volume 54, Issue 8, August 2024.The plasma membrane cholesterol homeostasis is regulated by SR‐BI (gene name: Scarb1) in mast cells contributing to the synergistically enhanced pro‐inflammatory cytokine production upon co‐stimulation of the FcεRI by antigen together with receptors acting in synergy. Scarb1 deficiency results in reduced plasma membrane‐localized cholesterol leading to
Sandro Capellmann +3 more
wiley +1 more source
Contributions of the pore-forming toxin Listeriolysin O to Listeria monocytogenes pathogenesis [PDF]
, 2019 Listeriolysin O (LLO) is an essential determinant of Listeria monocytogenes pathogenesis that mediates the escape of L. monocytogenes from host cell vacuoles, thereby allowing replication in the cytosol without causing appreciable cell death. As a member
Nguyen, Brittney Nhu-Chau
core
Membrane-translocating peptides and toxins: from nature to bedside [PDF]
, 2008 Today, different functional classes of bioactive peptides and toxins isolated from diverse sources of living organisms are known. In medicine, these polypeptides present the potential to be used structurally unmodified or to serve as templates for ...
Hayashi, Mirian Akemi Furuie +5 more
core +1 more source
Unique features of β‐cell metabolism are lost in type 2 diabetes
Acta Physiologica, Volume 240, Issue 6, June 2024.Abstract Pancreatic β cells play an essential role in the control of systemic glucose homeostasis as they sense blood glucose levels and respond by secreting insulin. Upon stimulating glucose uptake in insulin‐sensitive tissues post‐prandially, this anabolic hormone restores blood glucose levels to pre‐prandial levels. Maintaining physiological glucose
Felipe Muñoz +4 more
wiley +1 more source
CodY, a pleiotropic regulator, influences multicellular behaviour and efficient production of virulence factors in Bacillus cereus [PDF]
, 2012 In response to nutrient limitation in the environment, the global transcriptional regulator CodY modulates various pathways in low G+C Gram-positive bacteria.
Basset, Coraline +6 more
core +3 more sources
Tau induces inflammasome activation and microgliosis through acetylating NLRP3
Clinical and Translational Medicine, Volume 14, Issue 3, March 2024.• NLRP3 inflammasome is activated with increased NLRP3 acetylation in Tauopathy transgenic mice and AD patients. • Tau promotes NLRP3 acetylation and inflammasome activation dependent on K18 acetyltransferase activity domain. • Tau directly acetylates NLRP3 at K21, K22 and K24 site at its PYD domain and thereby induce inflammasome activation in vitro. •
Lun Zhang +23 more
wiley +1 more source