Results 81 to 90 of about 1,422 (145)

The MICOS Complex Subunit Mic60 is Hijacked by Intracellular Bacteria to Manipulate Mitochondrial Dynamics and Promote Bacterial Pathogenicity

Advanced Science, Volume 11, Issue 46, December 11, 2024.
Upon the invasion of Listeria monocytogenes into a host cell, the primary virulence factor, listeriolysin O (LLO), secreted by the bacterium, has the capacity to breach the mitochondrial membrane, thereby gaining access to the inner mitochondrial membrane (IMM). The interaction between LLO and Mic60 can induce significant changes in the architecture of
Changyong Cheng, Mianmian Chen, Jing Sun, Jiali Xu, Simin Deng, Jing Xia, Yue Han, Xian Zhang, Jing Wang, Lei Lei, Ruidong Zhai, Qin Wu, Weihuan Fang, Houhui Song   +13 more
wiley   +1 more source

The EngCP endo α-N-acetylgalactosaminidase is a virulence factor involved in Clostridium perfringens gas gangrene infections

International Journal of Medical Microbiology, 2020
Clostridium perfringens is the causative agent of human clostridial myonecrosis; the major toxins involved in this disease are α-toxin and perfringolysin O.
Jackie K. Cheung, Vicki Adams, Danielle D’Souza, Meagan James, Christopher J. Day, Michael P. Jennings, Dena Lyras, Julian I. Rood   +7 more
doaj   +1 more source

Functional analysis of the VirSR phosphorelay from Clostridium perfringens. [PDF]

PLoS ONE, 2009
Toxin production in Clostridium perfringens is controlled by the VirSR two-component signal transduction system, which comprises the VirS sensor histidine kinase and the VirR response regulator.
Jackie K Cheung, Milena M Awad, Sheena McGowan, Julian I Rood   +3 more
doaj   +1 more source

Matching Together Living Cells and Prototissues: Will There Be Chemistry?

ChemBioChem, Volume 25, Issue 18, September 16, 2024.
In the field of tissue engineering, the combination of synthetic and living tissues could be the turning point. In this work we review examples of hybrid protocell/living cell and prototissue/living cell systems, focusing on the chemistry that makes the integration between non‐living and living matter efficient.
Stefano Valente, Agostino Galanti, Edoardo Maghin, Nahid Najdi, Martina Piccoli, Pierangelo Gobbo   +5 more
wiley   +1 more source

Lactobacillus gasseri and Gardnerella vaginalis produce extracellular vesicles that contribute to the function of the vaginal microbiome and modulate host–Trichomonas vaginalis interactions

Molecular Microbiology, Volume 122, Issue 3, Page 357-371, September 2024.
Our study investigates the influence of extracellular vesicles, released by two bacterial species of the human cervicovaginal microbiome, on the infection by Trichomonas vaginalis. We described species‐specific protein cargoes of these vesicles matching the expected contribution of the bacteria to this biome.
Anastasiia Artuyants, Jiwon Hong, Priscila Dauros‐Singorenko, Anthony Phillips, Augusto Simoes‐Barbosa   +4 more
wiley   +1 more source

SR‐BI regulates the synergistic mast cell response by modulating the plasma membrane‐associated cholesterol pool

European Journal of Immunology, Volume 54, Issue 8, August 2024.
The plasma membrane cholesterol homeostasis is regulated by SR‐BI (gene name: Scarb1) in mast cells contributing to the synergistically enhanced pro‐inflammatory cytokine production upon co‐stimulation of the FcεRI by antigen together with receptors acting in synergy. Scarb1 deficiency results in reduced plasma membrane‐localized cholesterol leading to
Sandro Capellmann, Marlies Kauffmann, Michel Arock, Michael Huber   +3 more
wiley   +1 more source

Preclinical evaluation of VAX-IP, a novel bacterial minicell-based biopharmaceutical for nonmuscle invasive bladder cancer

Molecular Therapy: Oncolytics, 2016
The development of new therapies that can prevent recurrence and progression of nonmuscle invasive bladder cancer remains an unmet clinical need. The continued cost of monitoring and treatment of recurrent disease, along with its high prevalence and ...
Shingo Tsuji, Xuguang Chen, Bryan Hancock, Veronica Hernandez, Barbara Visentin, Katherine Reil, Roger Sabbadini, Matthew Giacalone, WT Godbey   +8 more
doaj   +1 more source

Unique features of β‐cell metabolism are lost in type 2 diabetes

Acta Physiologica, Volume 240, Issue 6, June 2024.
Abstract Pancreatic β cells play an essential role in the control of systemic glucose homeostasis as they sense blood glucose levels and respond by secreting insulin. Upon stimulating glucose uptake in insulin‐sensitive tissues post‐prandially, this anabolic hormone restores blood glucose levels to pre‐prandial levels. Maintaining physiological glucose
Felipe Muñoz, Malin Fex, Thomas Moritz, Hindrik Mulder, Luis Rodrigo Cataldo   +4 more
wiley   +1 more source

Tau induces inflammasome activation and microgliosis through acetylating NLRP3

Clinical and Translational Medicine, Volume 14, Issue 3, March 2024.
• NLRP3 inflammasome is activated with increased NLRP3 acetylation in Tauopathy transgenic mice and AD patients. • Tau promotes NLRP3 acetylation and inflammasome activation dependent on K18 acetyltransferase activity domain. • Tau directly acetylates NLRP3 at K21, K22 and K24 site at its PYD domain and thereby induce inflammasome activation in vitro. •
Lun Zhang, Yongkang Gai, Yushuang Liu, Dongli Meng, Yi Zeng, Yong Luo, Huiliang Zhang, Zhuoqun Wang, Mengzhe Yang, Yunfan Li, Yi Liu, Yiwen Lai, Jiayu Yang, Gang Wu, Yu Chen, Jingtan Zhu, Shaojun Liu, Tingting Yu, Ji Zeng, Jianzhi Wang, Dan Zhu, Xiaochuan Wang, Xiaoli Lan, Rong Liu   +23 more
wiley   +1 more source

A Nonpolycationic Fully Proteinaceous Multiagent System for Potent Targeted Delivery of siRNA

Molecular Therapy: Nucleic Acids, 2014
Protein-based methods of targeted short-interfering RNA (siRNA) delivery have the potential to solve some of the problems faced by nanoparticle-based methods, such as poor pharmacokinetics and biodistribution, low tumor penetration, and polydispersity ...
David V Liu, Nicole J Yang, K Dane Wittrup   +2 more
doaj   +1 more source