Results 81 to 90 of about 2,525 (205)
Seeligeriolysin O, a Cholesterol-Dependent Cytolysin of Listeria seeligeri, Induces Gamma Interferon from Spleen Cells of Mice [PDF]
, 2003 Seeligeriolysin O (LSO), one of the cholesterol-dependent cytolysins produced by Listeria seeligeri, shows 80% homology to listeriolysin O (LLO) produced by Listeria monocytogenes at the amino acid sequence level.
Ito, Yutaka +7 more
core +1 more source
In Situ Vaccines in the Era of Cancer Immunotherapy: Conceptual Innovation and Clinical Translation
Advanced Science, Volume 12, Issue 37, October 6, 2025.In this review, the basic concepts of in situ vaccination are discussed, its advantages over conventional vaccines, and key historical milestones, from the first use of Coley's toxins to the most recent FDA‐approved in situ vaccine for bladder cancer.
Yiru Shi +4 more
wiley +1 more source
A Multiorgan Trafficking Circuit Provides Purifying Selection of Listeria monocytogenes Virulence Genes. [PDF]
, 2019 Listeria monocytogenes can cause a life-threatening illness when the foodborne pathogen spreads beyond the intestinal tract to distant organs. Many aspects of the intestinal phase of L. monocytogenes pathogenesis remain unknown.
Becattini, Simone +4 more
core +2 more sources
High‐Resolution Patterned Delivery of Chemical Signals From 3D‐Printed Picoliter Droplet Networks
Advanced Materials, Volume 37, Issue 28, July 17, 2025.3D‐printed picoliter droplet networks have been fabricated that control gene expression in bacterial populations by releasing chemical signals with precise spatial definition and high temporal resolution. This system of effector release is widely applicable, offering diverse applications in biology and medicine.
Jorin Riexinger +7 more
wiley +1 more source
Comment on ‘Orthogonal lipid sensors identify transbilayer asymmetry of plasma membrane cholesterol’
eLife, 2018 The plasma membrane in mammalian cells is rich in cholesterol, but how the cholesterol is partitioned between the two leaflets of the plasma membrane remains a matter of debate. Recently, Liu et al. used domain 4 (D4) of perfringolysin O as a cholesterol
Kevin C Courtney +4 more
doaj +1 more source
Contribution of Histidine Residues to Oligomerization of θ-Toxin (Perfringolysin O), a Cholesterol-Binding Cytolysin [PDF]
Bioscience, Biotechnology, and Biochemistry, 1999 Theta-toxin (perfringolysin O) modified by diethyl pyrocarbonate, a histidine-specific reagent, lost its hemolytic activity. The modified toxin retains the activities of binding to and insertion into cholesterol-containing membranes but lacks the ability to form oligomers.
M, Nakamura +3 more
openaire +2 more sources
Light‐Triggered Protease‐Mediated Release of Actin‐Bound Cargo from Synthetic Cells
Advanced Biology, Volume 9, Issue 5, May 2025.TEV Prtoease‐mediated Releasable Actin‐binding Protein (TRAP) is a protein‐based platform consisting of a cargo tightly bound to reconstituted actin networks in synthetic cells which can be proteolyticly released from the bound actin, followed by its secretion through membrane translocation mediated by a cell‐penetrating peptide.
Mousumi Akter +3 more
wiley +1 more source
Toxins, 2023 Clostridium perfringens is a spore-forming, Gram-positive anaerobic pathogen that causes several disorders in humans and animals. A multidrug-resistant Clostridium strain was isolated from the fecal sample of a patient who was clinically suspected of ...
Reem AlJindan +5 more
doaj +1 more source
Advanced Science, Volume 12, Issue 15, April 17, 2025.A modular endosomal escape system boosts transfection efficiency of a DNA delivery agent. This system comprises a phospholipase fused to a split‐calbindin domain and a nanobody targeting CD9. In the extracellular space, the phospholipase is tightly bound to protein‐DNA complexes, released within endosomes at low calcium concentrations and recruited to ...
Alexander Klipp +5 more
wiley +1 more source
Nonclinical Development of BCG Replacement Vaccine Candidates
Vaccines, 2013 The failure of current Mycobacterium bovis bacille Calmette–Guérin (BCG) vaccines, given to neonates to protect against adult tuberculosis and the risk of using these live vaccines in HIV-infected infants, has emphasized the need for generating new, more
Bernd Eisele +14 more
doaj +1 more source