Results 61 to 70 of about 2,525 (205)

Bottom‐Up Coacervate‐Based Artificial Cells: Integrating Cellular Hallmarks into Complex Life‐Like Systems

Angewandte Chemie International Edition, EarlyView.
Current interest in artificial cell research underscores its potential to deepen our understanding of life's fundamental processes. This review highlights advances in bottom‐up coacervate‐based artificial cell engineering via combined integration of cellular hallmarks.
Arjan Hazegh Nikroo, Angshuman Das, Madelief A. M. Verwiel, Jan C. M. van Hest   +3 more
wiley   +1 more source

Single molecule compression reveals intra-protein forces drive cytotoxin pore formation

eLife, 2015
Perfringolysin O (PFO) is a prototypical member of a large family of pore-forming proteins that undergo a significant reduction in height during the transition from the membrane-assembled prepore to the membrane-inserted pore. Here, we show that targeted
Daniel M Czajkowsky, Jielin Sun, Yi Shen, Zhifeng Shao   +3 more
doaj   +1 more source

A live-cell ergosterol reporter for visualization of the effects of fluconazole on the human fungal pathogen Candida albicans

mBio, 2023
Ergosterol, an essential plasma membrane amphipathic lipid, is a major component of the fungal plasma membrane. Most fungal pathogens are susceptible to azole drugs that target ergosterol biosynthesis, and resistance/tolerance to azoles is increasingly ...
Antonio Serrano, Miguel A. Basante-Bedoya, Martine Bassilana, Robert A. Arkowitz   +3 more
doaj   +1 more source

Toxin-neutralizing antibodies protect against Clostridium perfringens challenge in an intestinal loop model for bovine enterotoxaemia [PDF]

, 2015
Bovine enterotoxaemia caused by Clostridium perfringens type A most often presents as a sudden death syndrome with necro-hemorrhagic small intestinal lesions in suckling calves and veal calves (Muylaert et al., 2010).
Deprez, Piet, Ducatelle, Richard, Goossens, Evy, Haesebrouck, Freddy, Pardon, Bart, Schauvliege, Stijn, Timbermont, Leen, Valgaeren, Bonnie, Van Immerseel, Filip, Verherstraeten, Stefanie   +9 more
core  

Conformational changes during pore formation by the perforin-related protein pleurotolysin [PDF]

, 2015
Membrane attack complex/perforin-like (MACPF) proteins comprise the largest superfamily of pore-forming proteins, playing crucial roles in immunity and pathogenesis.
AE Aleshin, AE Aleshin, AG Murzin, AJ Farrand, AP Pandurangan, BF Kafsack, Bradley A. Spicer, C Morita-Yamamuro, C Zheng, CF Reboul, CJ Rosado, CL Birmingham, Cyril F. Reboul, D Meusch, D Vasishtan, Daouda A. K. Traore, DH Lockert, DJ Slade, DM Czajkowsky, DW Schuerch, EF Pettersen, Eileen M. Hotze, EM Hotze, EM Hotze, H Unno, Helen R. Saibil, I Iacovache, Ilia Voskoboinik, Irene Farabella, J Rossjohn, J Tschopp, James C. Whisstock, JM Mancheno, Joseph A. Trapani, K Kadota, K Ota, Katherine Oliver, LA Shepard, LL Lovelace, LM Stevens, M Topf, MA Hadders, MA Hadders, MA Henstridge, Maya Topf, Michelle A. Dunstone, MT Degiacomi, MY Shen, N Sakurai, Natalya Lukoyanova, O Shatursky, Oded Kleifeld, R Ramachandran, R Ramachandran, Raimund Dutzler, RH Law, Rodney K. Tweten, Ruby H. P. Law, SJ Tilley, Stephanie C. Kondos, Susan M. Ekkel, T Tomita, Tamas Hatfaludi, Tom T. Caradoc-Davies   +63 more
core   +3 more sources

Living Microbial Drugs

Chemistry – A European Journal, EarlyView.
The introduction outlines the review scope. Microbial cell factories as living drugs cover host–gut microbiota, bacteria, yeast, and other microbial systems, with comparative host advantages. Engineering strategies include synthetic circuits, quorum sensing, and memory.
Cemile Elif Özçelik, Nazlıcan Tunç, Senem Şen, Urartu Özgür Şafak Şeker   +3 more
wiley   +1 more source

Three pools of plasma membrane cholesterol and their relation to cholesterol homeostasis

eLife, 2014
When human fibroblasts take up plasma low density lipoprotein (LDL), its cholesterol is liberated in lysosomes and eventually reaches the endoplasmic reticulum (ER) where it inhibits cholesterol synthesis by blocking activation of SREBPs.
Akash Das, Michael S Brown, Donald D Anderson, Joseph L Goldstein, Arun Radhakrishnan   +4 more
doaj   +1 more source

Progress and problems in vaccination against necrotic enteritis in broiler chickens [PDF]

, 2014
Necrotic enteritis in broilers is caused by Clostridium perfringens type A strains that produce the NetB toxin. Necrotic enteritis is one of the gastrointestinal diseases in poultry that has gained worldwide importance during the last decade due to ...
Ducatelle, Richard, Haesebrouck, Freddy, Mot, Dorien, Timbermont, Leen, Van Immerseel, Filip   +4 more
core   +2 more sources

Inactivation Strategies of Clostridium perfringens in Foods: Current Challenges and Emerging Interventions

Food Frontiers, Volume 7, Issue 3, May 2026.
Clostridium perfringens forms heat‐resistant spores that complicate food safety. Physical methods (thermal processing, HPP, vacuum cooling, ozone treatments) and chemical interventions (natural antimicrobials, phosphates, nitrate/nitrite, organic acids) reduce vegetative cells and spores, though spore resistance remains a major challenge in food and ...
Deepak Subedi, Bharath Mallavarapu, Pranita Patil, Sujitha Bhumanapalli, Sandesh Chapagain, Kham Bahadur Khatri, Milan Kandel, Amit Kumar Singh   +7 more
wiley   +1 more source

The Pore-Forming Haemolysins of Bacillus Cereus: A Review

Toxins, 2013
The Bacillus cereus sensu lato group contains diverse Gram-positive spore-forming bacteria that can cause gastrointestinal diseases and severe eye infections in humans. They have also been incriminated in a multitude of other severe, and frequently fatal,
Vincent Sanchis, Nalini Ramarao
doaj   +1 more source