Results 61 to 70 of about 1,422 (145)
Scientific Reports, 2019 Ketamine is an antidepressant with rapid therapeutic onset and long-lasting effect, although the underlying mechanism(s) remain unknown. Using FRET-based nanosensors we found that ketamine increases [cAMP]i in astrocytes. Membrane capacitance recordings,
Eva Lasič +10 more
doaj +1 more source
The cholesterol-dependent cytolysin signature motif: a critical element in the allosteric pathway that couples membrane binding to pore assembly. [PDF]
PLoS Pathogens, 2012 The cholesterol-dependent cytolysins (CDCs) constitute a family of pore-forming toxins that contribute to the pathogenesis of a large number of Gram-positive bacterial pathogens.The most highly conserved region in the primary structure of the CDCs is the
Kelley J Dowd +2 more
doaj +1 more source
Food Frontiers, Volume 7, Issue 3, May 2026.Clostridium perfringens forms heat‐resistant spores that complicate food safety. Physical methods (thermal processing, HPP, vacuum cooling, ozone treatments) and chemical interventions (natural antimicrobials, phosphates, nitrate/nitrite, organic acids) reduce vegetative cells and spores, though spore resistance remains a major challenge in food and ...
Deepak Subedi +7 more
wiley +1 more source
Frontiers in Cellular and Infection Microbiology, 2023 Clostridium perfringens type A is the main cause of necrotic enteritis (NE) in chickens. Since the use of antibiotics in feed is withdrawn, it is imperative to find out suitable alternatives to control NE.
Jin Liu +15 more
doaj +1 more source
The Plant Journal, Volume 126, Issue 1, April 2026.SUMMARY Self‐incompatibility (SI) is the single most important mechanism utilized by flowering plants to avoid self‐fertilization, thus preventing inbreeding and promoting outcrossing. Many plant SI systems are genetically controlled by a multi‐allelic S‐locus, containing two tightly linked genes that encode the female and male S‐determinants.
Zongcheng Lin +2 more
wiley +1 more source
Exploration, Volume 5, Issue 6, December 2025.We developed a spatiotemporal targeting oncolytic bacterial therapy system, the STEPT (spatiotemporal targeting EcN‐pfo terminator) system, which injects azide hyaluronic acid hydrogel into tumors to capture DBCO‐labeled engineered Escherichia coli Nissle 1917 (EcN).
Yu‐Jia Wang +9 more
wiley +1 more source
Comment on ‘Orthogonal lipid sensors identify transbilayer asymmetry of plasma membrane cholesterol’
eLife, 2018 The plasma membrane in mammalian cells is rich in cholesterol, but how the cholesterol is partitioned between the two leaflets of the plasma membrane remains a matter of debate. Recently, Liu et al. used domain 4 (D4) of perfringolysin O as a cholesterol
Kevin C Courtney +4 more
doaj +1 more source
In Situ Vaccines in the Era of Cancer Immunotherapy: Conceptual Innovation and Clinical Translation
Advanced Science, Volume 12, Issue 37, October 6, 2025.In this review, the basic concepts of in situ vaccination are discussed, its advantages over conventional vaccines, and key historical milestones, from the first use of Coley's toxins to the most recent FDA‐approved in situ vaccine for bladder cancer.
Yiru Shi +4 more
wiley +1 more source
Toxins, 2023 Clostridium perfringens is a spore-forming, Gram-positive anaerobic pathogen that causes several disorders in humans and animals. A multidrug-resistant Clostridium strain was isolated from the fecal sample of a patient who was clinically suspected of ...
Reem AlJindan +5 more
doaj +1 more source
Repurposing rabeprazole sodium as an anti-Clostridium perfringensdrug by inhibiting perfringolysin O
Journal of Applied Microbiology, 2023 AbstractAimsClostridium perfringens infections affect food safety, human health, and the development of the poultry feed industry. Anti-virulence is an alternative strategy to develop new drug. Perfringolysin O (PFO) is an exotoxin of C. perfringens that has been demonstrated to play critical roles in the pathogenesis of this organism, promising it an ...
Guizhen, Wang +8 more
openaire +2 more sources