Results 51 to 60 of about 1,422 (145)
Membrane‐Associated Biomolecules for Synthetic Cell Signalling
ChemBioChem, Volume 27, Issue 13, 14 July 2026.Membrane‐associated proteins and nucleic acids are transforming synthetic cell communication, unlocking applications in biosensing, therapeutics, and tissue engineering. This review explores how these biomolecules enable complementary strategies for cell tethering, vesicle generation and fusion, signal transmission, and signal transduction.
Chelsea Dack +3 more
wiley +1 more source
Single molecule compression reveals intra-protein forces drive cytotoxin pore formation
eLife, 2015 Perfringolysin O (PFO) is a prototypical member of a large family of pore-forming proteins that undergo a significant reduction in height during the transition from the membrane-assembled prepore to the membrane-inserted pore. Here, we show that targeted
Daniel M Czajkowsky +3 more
doaj +1 more source
Single-Molecule Imaging of Perfringolysin O Binding and Assembly on Model Membranes [PDF]
Biophysical Journal, 2016 Perfringolysin O (PFO) is the archetypical pore-forming toxin in the cholesterol-dependent cytolysin (CDC) family, which is implicated in major infections ranging from food poisoning to pneumonia and meningitis. Like other CDCs, transmembrane pores are formed when PFO monomers bind to cholesterol-containing membranes and oligomerize into larger (30-50 ...
Senior, Michael J. +4 more
openaire +1 more source
Chemistry – A European Journal, Volume 32, Issue 26, 11 July 2026.The introduction outlines the review scope. Microbial cell factories as living drugs cover host–gut microbiota, bacteria, yeast, and other microbial systems, with comparative host advantages. Engineering strategies include synthetic circuits, quorum sensing, and memory.
Cemile Elif Özçelik +3 more
wiley +1 more source
Three pools of plasma membrane cholesterol and their relation to cholesterol homeostasis
eLife, 2014 When human fibroblasts take up plasma low density lipoprotein (LDL), its cholesterol is liberated in lysosomes and eventually reaches the endoplasmic reticulum (ER) where it inhibits cholesterol synthesis by blocking activation of SREBPs.
Akash Das +4 more
doaj +1 more source
mBio, 2023 Ergosterol, an essential plasma membrane amphipathic lipid, is a major component of the fungal plasma membrane. Most fungal pathogens are susceptible to azole drugs that target ergosterol biosynthesis, and resistance/tolerance to azoles is increasingly ...
Antonio Serrano +3 more
doaj +1 more source
Journal of Food Science, Volume 91, Issue 6, June 2026.ABSTRACT Clostridium perfringens (C. perfringens) biofilms pose a persistent challenge in meat and poultry processing environments due to their structural resilience, spore‐mediated survival and toxin‐associated virulence. These biofilms readily develop on food‐contact surfaces under typical processing conditions including organic residue accumulation,
Md Anamul Hasan Chowdhury +4 more
wiley +1 more source
The Pore-Forming Haemolysins of Bacillus Cereus: A Review
Toxins, 2013 The Bacillus cereus sensu lato group contains diverse Gram-positive spore-forming bacteria that can cause gastrointestinal diseases and severe eye infections in humans. They have also been incriminated in a multitude of other severe, and frequently fatal,
Vincent Sanchis, Nalini Ramarao
doaj +1 more source
Journal of Lipid Research, 2003 BCθ is a proteolytically nicked and biotinylated derivative of a cholesterol binding protein perfringolysin O (θ-toxin), and has been used to detect cholesterol-rich domains at the plasma membrane (PM).
Shigeki Sugii +7 more
doaj +1 more source
Journal of Lipid Research, 2021 Cholesterol is an essential component of the mammalian plasma membrane involved in diverse cellular processes. Our recent quantitative imaging analysis using ratiometric cholesterol sensors showed that the available cholesterol concentration in the inner
Pawanthi Buwaneka +3 more
doaj +1 more source