Use of an EZ-Tn5-based random mutagenesis system to identify a novel toxin regulatory locus in Clostridium perfringens strain 13. [PDF]
PLoS ONE, 2009 BACKGROUND:Although useful for probing bacterial pathogenesis and physiology, current random mutagenesis systems suffer limitations for studying the toxin-producing bacterium Clostridium perfringens.
Jorge E Vidal +3 more
doaj +1 more source
Toxin-neutralizing antibodies protect against Clostridium perfringens-induced necrosis in an intestinal loop model for bovine necrohemorrhagic enteritis [PDF]
, 2016 Background: Bovine necrohemorrhagic enteritis is caused by Clostridium perfringens type A. Due to the rapid progress and fatal outcome of the disease, vaccination would be of high value. In this study, C.
Deprez, Piet +10 more
core +2 more sources
An update on the human and animal enteric pathogen Clostridium perfringens [PDF]
, 2018 Clostridium perfringens, a rapid-growing pathogen known to secrete an arsenal of >20 virulent toxins, has been associated with intestinal diseases in both animals and humans throughout the past century.
Cavalieri, A. V. G. +4 more
core +3 more sources
Selective binding of perfringolysin O derivative to cholesterol-rich membrane microdomains (rafts) [PDF]
Proceedings of the National Academy of Sciences, 2001 There is increasing evidence that sphingolipid- and cholesterol-rich microdomains (rafts) exist in the plasma membrane. Specific proteins assemble in these membrane domains and play a role in signal transduction and many other cellular events.
A A, Waheed +8 more
openaire +2 more sources
Rethinking the role of alpha toxin in Clostridium perfringens-associated enteric diseases : a review on bovine necro-haemorrhagic enteritis [PDF]
, 2017 Bovine necro-haemorrhagic enteritis is an economically important disease caused by Clostridium perfringens type A strains. The disease mainly affects calves under intensive rearing conditions and is characterized by sudden death associated with small ...
Deprez, Piet +6 more
core +3 more sources
Advanced Science, Volume 10, Issue 33, November 24, 2023., 2023 Plasma membrane is routinely exposed to diffuse or focal injury, whose repair is facilitated by the cellular compartments. This study identifies early endosomes as a calcium‐regulated exocytic compartment. Regulated exocytosis of early endosome helps repair focal injury, and repair of toxin‐induced diffuse injury to plasma membrane requires both ...
Daniel C. Bittel, Jyoti K. Jaiswal
wiley +1 more source
The crystal structure of Pneumolysin at 2.0 Å resolution reveals the molecular packing of the pre-pore complex [PDF]
, 2015 Pneumolysin is a cholesterol-dependent cytolysin (CDC) and virulence factor of Streptococcus pneumoniae. It kills cells by forming pores assembled from oligomeric rings in cholesterol-containing membranes.
Andrew, Peter W +8 more
core +1 more source
Clinical and Translational Discovery, Volume 3, Issue 5, October 2023., 2023 1.Annexin A2 is a key repair protein that works with S100A10 and other S100 proteins to execute its membrane repair and extracellular roles. 2.Annexin A2 is a therapeutic target because the loss of annexin A2 function enhances cellular degeneration, which exacerbates muscular dystrophy and cardiovascular disease.
Victor G. Kayejo +3 more
wiley +1 more source
PLoS Pathogens, 2008 Reduced tissue perfusion leading to tissue ischemia is a central component of the pathogenesis of myonecrosis caused by Clostridium perfringens. The C.
Michael J Hickey +9 more
doaj +1 more source
The C-terminal domain of Clostridium perfringens alpha toxin as a vaccine candidate against bovine necrohemorrhagic enteritis [PDF]
, 2016 Bovine necrohemorrhagic enteritis is caused by Clostridium perfringens and leads to sudden death. Alpha toxin, together with perfringolysin O, has been identified as the principal toxin involved in the pathogenesis.
Deprez, Piet +10 more
core +4 more sources