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Food Science and Human WellnessFoodborne pathogens are the leading causes of human diseases that result in hundreds of thousands of deaths annually. Clostridium perfringens is a notorious foodborne pathogen of global significance that is known to produce a large repertoire of toxic ...
Xinyi Wang +4 more
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The solution structure and oligomerization behavior of two bacterial toxins: pneumolysin and perfringolysin O. [PDF]
Biophys J, 2004 Pneumolysin (PLY), an important protein virulence factor of the human bacterial pathogen Streptococcus pneumoniae, could be a candidate for inclusion in a new anti-streptococcal vaccine. PLY solution species from monomer via multimeric intermediates to ring-shaped oligomers were studied with time-dependent sedimentation velocity in the analytical ...
Solovyova AS +3 more
europepmc +4 more sources
Hexameric-Based Hierarchy in the Sizes of a Cytolysin Pore-Forming Complex [PDF]
BiomoleculesPerfringolysin O (PFO) is a prototypical member of a large family of pore-forming toxins (PFTs) that are potent virulence factors for many pathogenic bacteria.
Meijun Liu +7 more
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An autopsy case of gas gangrene, massive intravascular hemolysis, and cytokine storm due to Clostridium perfringens type A infection [PDF]
IDCasesClostridium perfringens bacteremia is a rare but rapidly fatal condition, especially in patients exhibiting massive intravascular hemolysis (MIH), gas gangrene, and septic shock. Herein, we present an autopsy case of C.
Akane Hara +8 more
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Journal of Lipid Research, 2023 Almost all the cholesterol in cellular membranes is associated with phospholipids in simple stoichiometric complexes. This limits the binding of sterol ligands such as filipin and perfringolysin O (PFO) to a small fraction of the total. We offer a simple
Yvonne Lange +2 more
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Imaging the Assembly of Perfringolysin O [PDF]
Biophysical Journal, 2015 Cholesterol-dependent cytolysins such as Perfringolysin O (PFO) lyse cells by forming large pores in the target cell membrane; they contribute to infections ranging from food poisoning to pneumonia and listeriosis. PFO monomers bind the target membrane and then oligomerize via a pre-pore intermediate to form pores of 20-50 subunits.
Senior, Michael J. +3 more
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Decreasing Transmembrane Segment Length Greatly Decreases Perfringolysin O Pore Size [PDF]
The Journal of Membrane Biology, 2015 Perfringolysin O (PFO) is a transmembrane (TM) β-barrel protein that inserts into mammalian cell membranes. Once inserted into membranes, PFO assembles into pore-forming oligomers containing 30-50 PFO monomers. These form a pore of up to 300 Å, far exceeding the size of most other proteinaceous pores.
Qingqing, Lin +3 more
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Frontiers in Microbiology, 2021 Sepsis caused by Clostridium perfringens infection is rare but often fatal. The most serious complication leading to poor prognosis is massive intravascular hemolysis (MIH).
Ai Suzaki +7 more
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The projection structure of Perfringolysin O (Clostridium perfringens θ‐toxin) [PDF]
FEBS Letters, 1993 The cytolysin Perfringolysin O was applied to lipid layers and the obtained ring‐shaped oligomers analyzed by electron microscopy and image processing. The final result shows the periodic repeat of 2.4 nm along the outer rim of the ring. The asymmetric protein unit, corresponding to one monomer, spans the ring from the convex to the concave surface. It
Olofsson, Anders +2 more
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Microorganisms, 2020 Chlamydia trachomatis and Waddlia chondrophila are strict intracellular bacteria belonging to the Chlamydiales order. C. trachomatis is the most frequent bacterial cause of genital and ocular infections whereas W.
Carole Kebbi-Beghdadi +3 more
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