Results 21 to 30 of about 1,388 (159)
Hexameric-Based Hierarchy in the Sizes of a Cytolysin Pore-Forming Complex [PDF]
BiomoleculesPerfringolysin O (PFO) is a prototypical member of a large family of pore-forming toxins (PFTs) that are potent virulence factors for many pathogenic bacteria.
Meijun Liu +7 more
doaj +2 more sources
An autopsy case of gas gangrene, massive intravascular hemolysis, and cytokine storm due to Clostridium perfringens type A infection [PDF]
IDCasesClostridium perfringens bacteremia is a rare but rapidly fatal condition, especially in patients exhibiting massive intravascular hemolysis (MIH), gas gangrene, and septic shock. Herein, we present an autopsy case of C.
Akane Hara +8 more
doaj +2 more sources
Journal of Lipid Research, 2023 Almost all the cholesterol in cellular membranes is associated with phospholipids in simple stoichiometric complexes. This limits the binding of sterol ligands such as filipin and perfringolysin O (PFO) to a small fraction of the total. We offer a simple
Yvonne Lange +2 more
doaj +1 more source
Imaging the Assembly of Perfringolysin O [PDF]
Biophysical Journal, 2015 Cholesterol-dependent cytolysins such as Perfringolysin O (PFO) lyse cells by forming large pores in the target cell membrane; they contribute to infections ranging from food poisoning to pneumonia and listeriosis. PFO monomers bind the target membrane and then oligomerize via a pre-pore intermediate to form pores of 20-50 subunits.
Senior, Michael J. +3 more
openaire +1 more source
Frontiers in Microbiology, 2021 Sepsis caused by Clostridium perfringens infection is rare but often fatal. The most serious complication leading to poor prognosis is massive intravascular hemolysis (MIH).
Ai Suzaki +7 more
doaj +1 more source
Decreasing Transmembrane Segment Length Greatly Decreases Perfringolysin O Pore Size [PDF]
The Journal of Membrane Biology, 2015 Perfringolysin O (PFO) is a transmembrane (TM) β-barrel protein that inserts into mammalian cell membranes. Once inserted into membranes, PFO assembles into pore-forming oligomers containing 30-50 PFO monomers. These form a pore of up to 300 Å, far exceeding the size of most other proteinaceous pores.
Qingqing, Lin +3 more
openaire +2 more sources
The projection structure of Perfringolysin O (Clostridium perfringens θ‐toxin) [PDF]
FEBS Letters, 1993 The cytolysin Perfringolysin O was applied to lipid layers and the obtained ring‐shaped oligomers analyzed by electron microscopy and image processing. The final result shows the periodic repeat of 2.4 nm along the outer rim of the ring. The asymmetric protein unit, corresponding to one monomer, spans the ring from the convex to the concave surface. It
Olofsson, Anders +2 more
openaire +2 more sources
Microorganisms, 2020 Chlamydia trachomatis and Waddlia chondrophila are strict intracellular bacteria belonging to the Chlamydiales order. C. trachomatis is the most frequent bacterial cause of genital and ocular infections whereas W.
Carole Kebbi-Beghdadi +3 more
doaj +1 more source
Advanced Science, Volume 10, Issue 33, November 24, 2023., 2023 Plasma membrane is routinely exposed to diffuse or focal injury, whose repair is facilitated by the cellular compartments. This study identifies early endosomes as a calcium‐regulated exocytic compartment. Regulated exocytosis of early endosome helps repair focal injury, and repair of toxin‐induced diffuse injury to plasma membrane requires both ...
Daniel C. Bittel, Jyoti K. Jaiswal
wiley +1 more source
Clinical and Translational Discovery, Volume 3, Issue 5, October 2023., 2023 1.Annexin A2 is a key repair protein that works with S100A10 and other S100 proteins to execute its membrane repair and extracellular roles. 2.Annexin A2 is a therapeutic target because the loss of annexin A2 function enhances cellular degeneration, which exacerbates muscular dystrophy and cardiovascular disease.
Victor G. Kayejo +3 more
wiley +1 more source