Results 131 to 140 of about 27,494 (299)

Cold atmospheric plasma‐mediated tumor microenvironment remodeling for cancer treatment

BMEMat, EarlyView.
Schematic presentation of CAP‐mediated TME remodeling. This review summarizes recent efforts in cold atmospheric plasma (CAP) application in cancer treatment, highlighting the anticancer potential of CAP, molecular mechanisms, and future perspectives for further improvement and clinical translation.
Israr Khan, Qiujie Fang, Cao Fei, Ziyuan Wang, Zhaowei Chen, Guojun Chen, Zhiming Xu, Shu Xu, Zhitong Chen   +8 more
wiley   +1 more source

Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases

BMEMat, EarlyView.
This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou, Jia Liu, Shulin Lai, Suhan Yin, Bingmin Luo, Longquan Shao, Yiyuan Kang   +6 more
wiley   +1 more source

Pericyte Expression of VEGF-A Minimally Impacts Ocular Vascular Development and Neovascularization

Cells
Pericytes produce vascular endothelial growth factor-A (VEGF-A; hereafter referred to as VEGF). VEGF inhibits pericyte proliferation and migration through enhanced VEGFR2 and PDGFRβ heterodimerization.
Yong-Seok Song, Shoujian Wang, Samay Inampudi, Hope Risa, Christine M. Sorenson, Nader Sheibani   +5 more
doaj   +1 more source

Reprogramming tumor immune microenvironment by ultrasound‐responsive nanoplatforms for enhanced cancer immunotherapy

BMEMat, EarlyView.
Ultrasound‐responsive nanoplatforms reprogram the tumor immune microenvironment by targeting tumor cells, immune cells, and non‐immune stromal cells to enhance the efficacy of cancer immunotherapy. Abstract Cancer immunotherapy represents a significant advancement in cancer treatment by enhancing the specific recognition and elimination of cancer cells.
Shilong Zhao, Rui Qu, Zan Dai, Xiqun Jiang, Xu Zhen   +4 more
wiley   +1 more source

A novel biomimetic liposome drug delivery system mediated by macrophage targeting for precision treatment of encephalitis

BMEMat, EarlyView.
An advanced macrophage‐mediated biomimetic liposome (AC‐LP@RAW) that can penetrate the BBB and precisely target inflammatory sites in the deep brain was established in this study based on the unique immune homing property of macrophages, and showed a significantly improved delivery of curcumin to the brain.
Mengru Wu, Baoqin Song, Zhihao Chen, Wenzhong Li, Wanjun Liang, Xiu Wang   +5 more
wiley   +1 more source

Pericyte phenotype and function.

, 2012
Assessment of pericyte phenotype by pericyte-specific 3G5 antibody (A, B) and function by seeding onto matrigel (C, D, E) in cells cultured with EGM-2 (A, C) or MSM (B, D). Cultured human umbilical vein endothelial cells (HUVECs) were incubated with anti-
Valérie Trichet (121670), Fabien Guilloton (121672), Nicolas Espagnolle (121674), Dominique Heymann (121679), Luc Sensébé (121684), Amina Bouacida (121667), Frédéric Deschaseaux (121687), Philippe Rosset (121669), Thomas Cordonier (121676), Pierre Layrolle (121682)   +9 more
core   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

The complex mural cell: Pericyte function in health and disease

, 2015
Pericytes are perivascular cells that can be distinguished from vascular smooth muscle cells by their specific morphology and expression of distinct molecular markers.
Duncker, Dirk-jan; id_orcid, Duncker, Dirk J., van Dijk, CGM, Xu, Yan Juan, van Mulligen, Elise; id_orcid, Verhaar, MC, Van Mulligen, Elise, Nieuweboer, FE, Verhaar, Marianne C., Xu, YJ (Yan Juan), Nieuweboer, Frederieke E., Pei, Jia Yi, Burgisser, Petra, El Azzouzi, Hamid, Van Dijk, Christian G M, Burgisser, P, el Azzouzi, H, Duncker, Dirk-jan, Cheng, Caroline, Pei, JY   +19 more
core   +1 more source

Biomaterials for modulating cellular responses of endogenous tendon stem/progenitor cells: A promising avenue for tendon regeneration

BMEMat, EarlyView.
This review comprehensively summarizes emerging biomaterial‐based strategies and underlying mechanisms for modulating endogenous tendon stem/progenitor cells (TSPCs). It offers the most recent insights into TSPC physiology and potential applications of tissue engineering and regenerative medicine in tendons.
Zeyu Zhu, Renwang Sheng, Mumin Cao, Ludvig J. Backman, Yucheng Gao, Hao Wang, Cheng Zhang, Jialin Chen, Wei Zhang, Yunfeng Rui   +9 more
wiley   +1 more source

Pericytes as Key Players in Retinal Diseases: A Comprehensive Narrative Review

Biology
Pericytes, specialized mural cells surrounding microvessels, play a crucial role in maintaining vascular homeostasis and function across various organs, including the eye.
Fabiana D’Esposito, Francesco Cappellani, Federico Visalli, Matteo Capobianco, Lorenzo Rapisarda, Alessandro Avitabile, Ludovica Cannizzaro, Roberta Malaguarnera, Giuseppe Gagliano, Antonino Maniaci, Mario Lentini, Giuseppe Montalbano, Mohamed Amine Zaouali, Dorra H’mida, Giovanni Giurdanella, Caterina Gagliano   +15 more
doaj   +1 more source