Results 231 to 240 of about 106,411 (380)

Navigating the Genetic Risk of Chemotherapy‐Induced Hearing Loss in the Stria Vascularis

Clinical Pharmacology &Therapeutics, EarlyView.
Cisplatin is a chemotherapy drug that causes permanent hearing loss by damaging a critical tissue lining the inner ear, called the stria vascularis (SV). Currently, the molecular mechanisms of SV damage are largely unknown and the incidence of ototoxicity in patients cannot be reliably predicted.
Tara Lazetic, Deanne Nixie R. Miao, Britt I. Drögemöller, Alain Dabdoub, Julia M. Abitbol   +4 more
wiley   +1 more source

Structure and function of neurovascular unit in arterial hypertension. [PDF]

Front Mol Neurosci
Kozniewska E, Aleksandrowicz M.
europepmc   +1 more source

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source

A biomimetic senotherapy replenishing MAT2A promotes wound regeneration in preclinical models. [PDF]

Nat Commun
Lv D, Ren L, Zhao Z, Rong Y, Chen M, Yang H, Yin R, Zeng R, Chao H, Li X, Xu Z, Hu Z, Cao X, Deng W, Tang Q, Tang B.   +15 more
europepmc   +1 more source

Notch1 promotes the pericyte-myofibroblast transition in idiopathic pulmonary fibrosis through the PDGFR/ROCK1 signal pathway [PDF]

, 2019
Yichun Wang, Qiong Chen, Junming Luo, Jing Nie, Qinghe Meng, Wei Shuai, Han Xie, Jia-Mei Xia, Hui Wang   +8 more
openalex   +1 more source

Brain pericytes increase sodium-dependent glutamate uptake in astrocytes.

, 2021
Fuyuko Takata, Kenta Sakai, Takuro Iwao, Junichi Matsumoto, Yasufumi Kataoka, Atsushi Yamauchi, Shinya Dohgu   +6 more
openalex   +2 more sources

Endometrial Stromal Cell Senescence: A Non‐Negligible Factor in Recurrent Pregnancy Loss

iMetaMed, EarlyView.
As populations age, links between female reproductive aging and infertility are increasingly evident. Cellular senescence, characterized by near‐irreversible cell‐cycle arrest and accumulation of damage, can impair tissue function. In the endometrium, aberrant senescence of endometrial stromal cells (EnSCs) may compromise receptivity, hinder embryo ...
Shuang Wu, Cenlan Bu, Qinzheng Xu, Xi Cheng, Junrong Zhang, Jinling Chen, Yun‐Zhao Xu   +6 more
wiley   +1 more source

Characterizing pericytes and the vascular transition zones of the human macula in postmortem eyes. [PDF]

Fluids Barriers CNS
Greenwood JI, Fadakar K, Hsieh YW, Fawzi AA.   +3 more
europepmc   +1 more source

Organoids and organ‐on‐a‐chip models for investigating the pathophysiology of the human reproductive system

Interdisciplinary Medicine, EarlyView.
Organoids and organ‐on‐a‐chips are advancing reproductive system research. In the female reproductive system, applications include cancer organoid models, placental chips, and hormone simulation models. For the male reproductive system, research focuses on drug resistance mechanisms, co‐culture platforms, and infertility studies. These refined in vitro
Hongqi Zhang, Shiwen Deng, Fangfang Jin, Jiayao Qu, Xiang Fan, Peng Chen, Xinrong Fan   +6 more
wiley   +1 more source

A human blood-brain barrier model reveals pericytes as critical regulators of viral neuroinvasion. [PDF]

iScience
Richards A, Khalil A, Bisht P, Whitfield TW, Gao X, Mooney D, Gehrke L, Jaenisch R.   +7 more
europepmc   +1 more source