Results 51 to 60 of about 106,411 (380)

Pericyte Migration [PDF]

Diabetes, 2008
OBJECTIVE— The mechanism underlying pericyte loss during incipient diabetic retinopathy remains controversial. Hyperglycemia induces angiopoietin-2 (Ang-2) transcription, which modulates capillary pericyte coverage. In this study, we assessed loss of pericyte subgroups and the contribution of Ang-2 to pericyte migration.
Frederick Pfister, Yuxi Feng, Franziska vom Hagen, Sigrid Hoffmann, Grietje Molema, Jan-Luuk Hillebrands, Moshe Shani, Urban Deutsch, Hans-Peter Hammes   +8 more
openaire   +1 more source

Pericyte mechanics and mechanobiology [PDF]

Journal of Cell Science, 2021
ABSTRACT Pericytes are mural cells of the microvasculature, recognized by their thin processes and protruding cell body. Pericytes wrap around endothelial cells and play a central role in regulating various endothelial functions, including angiogenesis and inflammation.
Claire A. Dessalles, Avin Babataheri, Abdul I. Barakat   +2 more
openaire   +3 more sources

Brain pericyte biology: from physiopathological mechanisms to potential therapeutic applications in ischemic stroke

Frontiers in Cellular Neuroscience, 2023
Pericytes play an indispensable role in various organs and biological processes, such as promoting angiogenesis, regulating microvascular blood flow, and participating in immune responses.
Jiaqi Fu, Jiaqi Fu, Huazheng Liang, Ping Yuan, Zhenyu Wei, Ping Zhong, Ping Zhong   +6 more
doaj   +1 more source

RET mutation and increased angiogenesis in medullary thyroid carcinomas [PDF]

, 2016
Advanced medullary thyroid cancers (MTCs) are now being treated with drugs that inhibit receptor tyrosine kinases, many of which involved in angiogenesis.
Acquaviva, Giorgia, Boichard, Amélie, Casadei, Gian Piero, Checquolo, Saula, Colato, Chiara, de Biase, Dario, Durante, Cosimo, Ferdeghini, Marco, Filetti, Sebastiano, Pecce, Valeria, Rhoden, Kerry, Rosignolo, Francesca, Russo, Diego, Sponziello, Marialuisa, Tallini, Giovanni, Verrienti, Antonella, Visani, Michela   +16 more
core   +1 more source

The complex TIE between macrophages and angiogenesis [PDF]

, 2020
Macrophages are primarily known as phagocytic immune cells, but they also play a role in diverse processes, such as morphogenesis, homeostasis and regeneration.
Anghelina M., Avraham‐Davidi I., Baer C., Bailey A. S., Barnett F. H., Bonnardel J., Chakarov S., Chen L., Coffelt S. B., Corliss B. A., Cursiefen C., Daly C., Davies L. C., Davies L. C., De Palma M., De Palma M., De Palma M., De Palma M., De Palma M., De Spiegelaere W., DeFalco T., Deshmane S. L., Detry B., Dimova I., Dimova I., Eklund L., Elamaa H., Eubank T. D., Fantin A., Ferrari G., Fukuhara S., Ganta V. C., Ganta V. C., García S., Gerri C., Grunewald M., Guo L., Gurevich D. B., Hamm A., Hazan A. D., He H., Hoeffel G., Itoh M., Jetten N., Kim M., Kochhan E., Korhonen E. A., Korpelainen E. I., Krishnasamy K., Kumar A. H., Leibovich S. J., Lim H. Y., Liu C., Lucas T., Master Z., Metharom P., Michaeli S., Moldovan N. I., Moore E. M., Mueller S. B., Murdoch C., Murray P. J., Patel A. S., Polverini P. J., Potente M., Pucci F., Saharinen P., Saharinen P., Schif‐Zuck S., Schmeisser A., Seaman S. A., Seok S. H., Spiller K. L., Venneri M. A., Vestweber D., Webster N. L., West M. E. D., Willenborg S., Yamamoto S., Zajac E., Zenker D., Zhang W.   +81 more
core   +2 more sources

Ultrastructure of neurovascular changes in human diabetic retinopathy [PDF]

, 2018
The previous concept regarding diabetic retinopathy assigned a primary role to hyperglycemia-induced microvascular alterations, while neuronal and glial abnormalities were considered to be secondary to either ischemia or exudation.
Artico, Marco, Biró, Zsolt, Fehér, János, Micera, Alessandra, Orlando, Maria Patrizia, Scuderi, Gianluca, Spoletini, Maria Luisa, Taurone, Samanta, Turchetta, Rosaria, Varsányi, Balázs   +9 more
core   +1 more source

Neuroinflammation and myelin status in Alzheimer’s disease, Parkinson’s disease, and normal aging brains: A small sample study [PDF]

, 2019
Microglia and astrocytes play important roles in mediating the immune processes and nutritional support in the central nervous system (CNS). Neuroinflammation has been indicated in the progression of neurodegenerative diseases Alzheimer’s disease (AD ...
Benzinger, Tammie L. S., Han, Fei, Morris, John C., Perlmutter, Joel S., Perrin, Richard J., Wang, Qing, Wang, Yong, Xu, Jinbin   +7 more
core   +2 more sources

Pericytes Across the Lifetime in the Central Nervous System

Frontiers in Cellular Neuroscience, 2021
The pericyte is a perivascular cell type that encapsulates the microvasculature of the brain and spinal cord. Pericytes play a crucial role in the development and maintenance of the blood-brain barrier (BBB) and have a multitude of important functions in
Hannah C. Bennett, Yongsoo Kim
semanticscholar   +1 more source

Current Perspective on the Location and Function of Gamma- Aminobutyric Acid (GABA) and its Metabolic Partners in the Kidney. [PDF]

, 2014
Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter located in the mammalian central nervous system, which binds to GABAA and GABAB receptors to mediate its neurological effects.
Dunn, Kadeshia, Kelley, Stephen P., Peppiatt-Wildman, Claire M., Wildman, Scott S.P.   +3 more
core   +1 more source

Inhibiting Ca2+ channels in Alzheimer’s disease model mice relaxes pericytes, improves cerebral blood flow and reduces immune cell stalling and hypoxia

Nature Neuroscience
Early in Alzheimer’s disease (AD), pericytes constrict capillaries, increasing their hydraulic resistance and trapping of immune cells and, thus, decreasing cerebral blood flow (CBF).
Nils Korte, Anna Barkaway, Jack A Wells, F. Freitas, H. Sethi, Stephen P. Andrews, J. Skidmore, Beth Stevens, David Attwell   +8 more
semanticscholar   +1 more source