Results 181 to 190 of about 5,812 (218)
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Perineuronal nets: past and present
Trends in Neurosciences, 1998Golgi ranked the peripheral reticulum--which adheres intimately to nerve cell surfaces--alongside the intracellular reticulum, or Golgi apparatus,which immortalized his name. At first dismissed as an artefact of capricious staining techniques, this peripheral reticulum, or perineuronal net, is now recognized as a genuine entity in neurocytology.
M R, Celio +3 more
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Perineuronal nets in the auditory system
Hearing Research, 2015Perineuronal nets (PNs) are a unique and complex meshwork of specific extracellular matrix molecules that ensheath a subset of neurons in many regions of the central nervous system (CNS). PNs appear late in development and are supposed to restrict synaptic plasticity and to stabilize functional neuronal connections.
Mandy, Sonntag +4 more
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Perineuronal Nets Protect Fear Memories from Erasure
Science, 2009Adult Fears Why are fear memories almost impossible to get rid of—even with extensive extinction training? Animal studies have shown that the efficacy of extinction learning depends on age. Fear memories in young animals can be permanently erased, but in adults they can be easily recovered after extinction ...
Gogolla, N. +3 more
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Perineuronal nets’ role in metabolism
American Journal of Physiology-Endocrinology and MetabolismPerineuronal nets (PNNs), specialized extracellular matrix (ECM) structures that envelop neurons, have recently been recognized as key players in the regulation of metabolism. This review explores the growing body of knowledge concerning PNNs and their role in metabolic control, drawing insights from recent research and relevant studies.
Nan Zhang +6 more
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Microglia-mediated degradation of perineuronal nets promotes pain
Science, 2022Activation of microglia in the spinal cord dorsal horn after peripheral nerve injury contributes to the development of pain hypersensitivity. How activated microglia selectively enhance the activity of spinal nociceptive circuits is not well understood. We discovered that after peripheral nerve injury, microglia degrade extracellular matrix structures,
Shannon Tansley +23 more
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Perineuronal nets potentially protect against oxidative stress
Experimental Neurology, 2004A specialized form of extracellular matrix (ECM) termed perineuronal nets (PNs) consisting of large aggregating chondroitin sulfate proteoglycans (CSPGs), with hyaluronan and tenascin as main components, surrounds subpopulations of neurons.
Markus, Morawski +4 more
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The two faces of perineuronal nets
NeuroReport, 2000Perineuronal nets are extracellular structures enwrapping the soma and proximal dendrites of some neurons known to be parvalbumin immunoreactive. The composition of the nets is not completely known, but it can change between different neurons. We studied the heterogeneous composition of a specific component of perineuronal nets, the signaling molecule ...
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The Perineuronal Net: A Weapon for a Challenge
Journal of the History of the Neurosciences, 1999Theories and data do not always fit and sometimes are sources of conflicts among scientists. This is the case of a morphological structure, the perineuronal net, which was denied on the basis of an ideological conflict between two giants of neurosciences: Camillo Golgi and Santiago Ramon y Cajal. The perineuronal net is a reticular structure enveloping
R, Spreafico +2 more
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Journal fur Hirnforschung, 1983
Perineuronal nets could be visualized with some Golgi methods in the rat's brain. Nets were seen in telencephalic, diencephalic and mesencephalic structures covering somata and proximal dendrites of different neuronal types. Some nets could be found originating from microglia cells. In most cases their origin is not recognizable.
K, Brauer, L, Werner, L, Leibnitz
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Perineuronal nets could be visualized with some Golgi methods in the rat's brain. Nets were seen in telencephalic, diencephalic and mesencephalic structures covering somata and proximal dendrites of different neuronal types. Some nets could be found originating from microglia cells. In most cases their origin is not recognizable.
K, Brauer, L, Werner, L, Leibnitz
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Extracellular matrix and perineuronal nets in CNS repair
Developmental Neurobiology, 2011AbstractA perineuronal net (PNN) is a layer of lattice‐like matrix which enwraps the surface of the soma and dendrites, and in some cases the axon initial segments, in sub‐populations of neurons in the central nervous system (CNS). First reported by Camillo Golgimore than a century ago, the molecular structure and the potential role of this matrix have
Jessica C F, Kwok +3 more
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