Results 161 to 170 of about 134,149 (194)

Voluntary exercise prevents and eradicates anxiety-like behavior by influencing parvalbumin-positive neurons, perineuronal nets, and microglia activation in corticolimbic regions of neuropathic pain rats

Neurobiology of Pain
Highlights • Partial sciatic nerve ligation (PSL) rats underwent voluntary exercise (VE).• VE partially improved nociceptive behavior.• VE prevented and eradicated pain-induced anxiety-like behavior.• VE modulated PSL-induced parvalbumin-positive and ...
Thu Nguyen Dang, Cuong Nguyen Van, Ryosuke Ochi, Hiroki Kuwamura, Tomoyuki Kurose, Yoki Nakamura, K. Hisaoka-Nakashima, N. Morioka, Hisao Nishijo, Naoto Fujita, Susumu Urakawa   +10 more
semanticscholar   +1 more source

Characterization of Perineuronal Nets in the Human Cerebellum

The Cerebellum
Perineuronal nets (PNNs) are condensed extracellular matrix structures that regulate synaptic plasticity and neuronal stability. While their distribution and function have been well characterized in rodents, PNNs remain largely understudied in the human cerebellum.
Refilwe, Mpai, Christa, Hercher, Claudia, Belliveau, Reza, Rahimian, Jasmine, Kotsiopoulos, Ally, Huang, Gohar, Fakhfouri, Maria Antonietta, Davoli, Gustavo, Turecki, Naguib, Mechawar   +9 more
openaire   +2 more sources

The role of corticolimbic perineuronal nets in mice with chronic neuropathic pain.

Pain
Chronic pain is associated with maladaptive plasticity of corticolimbic brain regions. Perineuronal nets (PNNs), specialized extracellular matrix structures that surround neurons, regulate brain plasticity.
S. Cermak, Gabriella Sekerková, Marco Martina, A. V. Apkarian   +3 more
semanticscholar   +1 more source

Perineuronal nets of glia.

Journal fur Hirnforschung, 1983
Perineuronal nets could be visualized with some Golgi methods in the rat's brain. Nets were seen in telencephalic, diencephalic and mesencephalic structures covering somata and proximal dendrites of different neuronal types. Some nets could be found originating from microglia cells. In most cases their origin is not recognizable.
K, Brauer, L, Werner, L, Leibnitz
openaire   +1 more source

Perineuronal net expression in the brain of a hibernating mammal

Brain Structure and Function, 2019
During hibernation, mammals like the 13-lined ground squirrel cycle between physiological extremes. Most of the hibernation season is spent in bouts of torpor, where body temperature, heart rate, and cerebral blood flow are all very low. However, the ground squirrels periodically enter into interbout arousals (IBAs), where physiological parameters ...
Anna, Marchand, Christine, Schwartz
openaire   +2 more sources

Microglia-mediated Perineuronal nets loss contributes to social memory deficit in male mice after repeated neonatal sevoflurane exposure.

Brain, behavior, and immunity
BACKGROUND Repeated early-life exposure to general anesthetics might affect social behavior. Perineuronal nets (PNNs), which enwrap around parvalbumin (PV) interneurons and support their function, are crucial for social memory.
Ziwen Shi, Jingwen Qin, Lin Gao, Fa Huang, Wei Wei, Tianyun Zhao, Xingrong Song, Xinying Guo   +7 more
semanticscholar   +1 more source

Perineuronal nets as regulators of parvalbumin interneuron function: Factors implicated in their formation and degradation

Basic & Clinical Pharmacology & Toxicology
The brain extracellular matrix (ECM) has garnered increasing attention as a fundamental component of brain function in a predominantly “neuron‐centric” paradigm.
Thamyris Santos-Silva, D. Colodete, J. R. Lisboa, Ícaro Silva Freitas, Caio Fábio Baeta Lopes, Victor Hadera, T. Lima, A. Souza, Felipe V. Gomes   +8 more
semanticscholar   +1 more source

Perineuronal Nets Protect Fear Memories from Erasure

Science, 2009
Adult Fears Why are fear memories almost impossible to get rid of—even with extensive extinction training? Animal studies have shown that the efficacy of extinction learning depends on age. Fear memories in young animals can be permanently erased, but in adults they can be easily recovered after extinction ...
Gogolla, N., Caroni, P., Luthi, A., Herry, C.   +3 more
openaire   +5 more sources

Extracellular matrix and perineuronal nets in CNS repair

Developmental Neurobiology, 2011
AbstractA perineuronal net (PNN) is a layer of lattice‐like matrix which enwraps the surface of the soma and dendrites, and in some cases the axon initial segments, in sub‐populations of neurons in the central nervous system (CNS). First reported by Camillo Golgimore than a century ago, the molecular structure and the potential role of this matrix have
Jessica C F, Kwok, Gunnar, Dick, Difei, Wang, James W, Fawcett   +3 more
openaire   +2 more sources

Perineuronal Nets: Old Structures, New Functions

The Neuroscientist
Perineuronal nets (PNNs) are morphologically distinct aggregates of extracellular matrix that predominantly ensheath fast-spiking GABAergic neurons in the brain. Discovered in the late 19th century by Camilo Golgi, PNNs have emerged as an important stabilizing structure of synapses during development.
Bhanu P. Tewari, Lata Chaunsali, Harald Sontheimer   +2 more
openaire   +2 more sources