Results 121 to 130 of about 17,102,650 (298)

Recurrence of hot days in the Stavropol krai under current climate conditions

open access: yesНаука. Инновации. Технологии
Heat is an unfavorable weather phenomenon, as it poses a serious threat to many sectors of the national economy: agriculture, energy, construction, etc.
Yu. L. Smerek   +3 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

open access: yesMolecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller   +17 more
wiley   +1 more source

Substring Counting with Insertions

open access: yesAlgorithms
Substring counting is a classical algorithmic problem with numerous solutions that achieve linear time complexity. In this paper, we address a variation of the problem where, given three strings p, t, and s, we are interested in the number of occurrences
Janez Brank, Tomaž Hočevar
doaj   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

open access: yesMolecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad   +35 more
wiley   +1 more source

Three Spreadsheet Models Of A Simple Pendulum

open access: yesSpreadsheets in Education, 2008
The paper gives three spreadsheet models of simple pendulum motion. In two of them, the graph of the pendulum angle is drawn upon the exact integral solution using numeric integration – the simpler model only uses spreadsheet functions, the general model
Jan Benacka
doaj  

Premières réalisations de la période dans le roman de chevalerie : Amadis en français et en allemand

open access: yesCahiers d’Études Germaniques
The romance of chivalry is a genre rather at odds with the period. Nevertheless, forms of complete argumentative movements, marked by syntactic complexity and programming the revelation of information, can be discerned in Des Essarts’ translation of the ...
Pascale MOUNIER, Delphine PASQUES
doaj   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Studying Gonadal development and Sex ratio of Rock Oyster (Saccostrea cucullata)

open access: yes‬‭Majallah-i ̒Ilmī-i Shīlāt-i Īrān, 1994
The annual pattern of gonadal development and sex ratio of the rock lobster, Saccostrea cucullata, inhabiting intertidal area, on the northeastern coast of the Persian Gulf was investigated. The oyster was studied by macroscopic examination of gonads and
P. Rostaeian
doaj  

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

open access: yesMolecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken   +7 more
wiley   +1 more source

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