Results 91 to 100 of about 356,744 (339)

Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration.

Journal of Clinical Investigation, 2013
Brain aging is associated with diminished circadian clock output and decreased expression of the core clock proteins, which regulate many aspects of cellular biochemistry and metabolism.
E. Musiek, M. Lim, Guangrui Yang, A. Bauer, Laura Qi, Yool Lee, J. Roh, X. Ortiz-González, Joshua T. Dearborn, J. Culver, E. Herzog, J. Hogenesch, D. Wozniak, K. Dikranian, B. Giasson, D. Weaver, D. Holtzman, G. FitzGerald   +17 more
semanticscholar   +1 more source

Bilirubin Targeting WNK1 to Alleviate NLRP3‐Mediated Neuroinflammation

Advanced Science, EarlyView.
At physiological concentrations, bilirubin binds to the kinase domain of WNK1, thereby augmenting its activity and facilitating the phosphorylation of downstream SPAK/OSR1. This phosphorylation inhibits KCC2 activity, leading to elevate intracellular chloride levels in neurons.
Linfei Mao, Jiayu Lu, Quanjun Yang, Zhenqi Liu, Cuiping Wu, Bingbing Ke, Kaiyan Su, Haolin Yuan, Yaqi Cui, Yao Wang, Richard Salvi, Guang Yang, Shankai Yin, Feng Liu, Chunyan Li   +14 more
wiley   +1 more source

Waveforms of molecular oscillations reveal circadian timekeeping mechanisms [PDF]

Commun. Biol. 1, 207 (2018), 2018
Circadian clocks play a pivotal role in orchestrating numerous physiological and developmental events. Waveform shapes of the oscillations of protein abundances can be informative about the underlying biochemical processes of circadian clocks. We derive a mathematical framework where waveforms do reveal hidden biochemical mechanisms of circadian ...
arxiv   +1 more source

Oxytocin Improves Autistic Behaviors by Positively Shifting GABA Reversal Potential via NKCC1 in Early‐Postnatal‐Stage

Advanced Science, EarlyView.
New research reveals that oxytocin signaling during the early postnatal period is critical for regulating brain development and social behavior. Selectively suppressing oxytocin neurons by chemogenetic method shows that early—but not late—disruption leads to autism‐like behaviors.
Zi‐Hui Wang, Chang Xu, Yao‐Yao Ma, Wei‐Xuan Xue, Hao‐Yuan Wang, Lin‐Yao Fan, Chen‐Yu Zhang, Liang Li, Xiao‐Yang Zhang, Jing‐Ning Zhu, Qi‐Peng Zhang   +10 more
wiley   +1 more source

Phosphorylation of the Transcription Activator CLOCK Regulates Progression through a ∼24-h Feedback Loop to Influence the Circadian Period in Drosophila*

Journal of Biological Chemistry, 2014
Background: CLOCK phosphorylation coincides with circadian rhythms in transcription. Results: CLOCK phosphorylation sites are identified that regulate the timing and level of transcriptional activity and influence circadian period.
Guruswamy Mahesh, EunHee Jeong, F. Ng, Yixiao Liu, Kushan L. Gunawardhana, Jerry H. Houl, Evrim Yildirim, R. Amunugama, Richard N. Jones, D. Allen, I. Edery, Eun Young Kim, P. Hardin   +12 more
semanticscholar   +1 more source

Rapid and Noninvasive Early Detection of Lung Cancer by Integration of Machine Learning and Salivary Metabolic Fingerprints Using MS LOC Platform: A Large‐Scale Multicenter Study

Advanced Science, EarlyView.
Salivary metabolic signatures associated with lung cancer are systematically characterized through a self‐developed high‐throughput mass spectrometry Lab‐on‐a‐Chip platform. Utilizing these metabolic fingerprints, SalivaMLD, an integrated machine‐learning‐driven classification model is developed and demonstrates superior performance in detecting lung ...
Shuang Lin, Runlan Yan, Junqi Zhu, Bei Li, Yinyan Zhong, Shuang Han, Huiting Wang, Jianmin Wu, Zhao Chen, Yuyue Jiang, Aiwu Pan, Xuqing Huang, Xiaoming Chen, Pingya Zhu, Sheng Cao, Wenhua Liang, Peng Ye, Yue Gao   +17 more
wiley   +1 more source

Glial Cells in the Genesis and Regulation of Circadian Rhythms

Frontiers in Physiology, 2018
Circadian rhythms are biological oscillations with a period of ~24 h. These rhythms are orchestrated by a circadian timekeeper in the suprachiasmatic nucleus of the hypothalamus, the circadian “master clock,” which exactly adjusts clock outputs to solar ...
Donají Chi-Castañeda, Donají Chi-Castañeda, Arturo Ortega   +2 more
doaj   +1 more source

A Touch Enabled Hemodynamic and Metabolic Monitor

Advanced Science, EarlyView.
This work presents a touch‐based hybrid platform for simultaneous monitoring of vital signs and sweat metabolites. With a simple tri‐finger touch of 4–6 min, users can concurrently get to know their glucose, uric acid, cortisol levels from fingertip sweat, along with blood pressure and heart rate.
Omeed Djassemi, Tamoghna Saha, Ponnusamy Nandhakumar, Muhammad Inam Khan, Hannah Fishman, Sara Earney, Chochanon Moonla, Yuchen Xu, Henry Thai, Sofia Morales‐Fermin, Gyeongho Kim, Rhea Park, Beya Acot, Oscar Wu, Cannon Wurster, An‐Yi Chang, Christopher Cheung, Julia Silberman, Shichao Ding, Joseph Wang   +19 more
wiley   +1 more source

Generic temperature compensation of biological clocks by autonomous regulation of catalyst concentration [PDF]

, 2011
Circadian clocks ubiquitous in life forms ranging bacteria to multi-cellular organisms, often exhibit intrinsic temperature compensation; the period of circadian oscillators is maintained constant over a range of physiological temperatures, despite the expected Arrhenius form for the reaction coefficient.
arxiv   +1 more source

Parametric modeling of mechanical effects on circadian oscillators [PDF]

arXiv, 2023
Circadian rhythms are archetypical examples of nonlinear oscillations. While these oscillations are usually attributed to circuits of biochemical interactions among clock genes and proteins, recent experimental studies reveal that they are also affected by the cell's mechanical environment.
arxiv