Results 111 to 120 of about 356,744 (339)
Distinct functions of Period2 and Period3 in the mouse circadian system revealed by in vitro analysis. [PDF]
PLoS ONE, 2010 The mammalian circadian system, which is composed of a master pacemaker in the suprachiasmatic nuclei (SCN) as well as other oscillators in the brain and peripheral tissues, controls daily rhythms of behavior and physiology.
Julie S Pendergast +2 more
doaj +1 more source
PLoS Genetics, 2013 Circadian rhythms in Drosophila rely on cyclic regulation of the period (per) and timeless (tim) clock genes. The molecular cycle requires rhythmic phosphorylation of PER and TIM proteins, which is mediated by several kinases and phosphatases such as ...
David S. Garbe +6 more
semanticscholar +1 more source
Alterations in gut microbiota and metabolites contribute to postoperative sleep disturbances
Animal Models and Experimental Medicine, EarlyView.In this study, we classified postoperative patients into poor sleepers (PS) and good sleepers (GS) based on the bispectral index (BIS), and transplanted their fecal microbiota to pseudo‐germ‐free rats to analyze the sleep changes in rats and the potential mechanism.
Hui Zhong +7 more
wiley +1 more source
Frontiers in Molecular Neuroscience, 2018 Endogenous molecular circadian clocks drive daily rhythmic changes at the cellular, physiological, and behavioral level for adaptation to and anticipation of environmental signals.
Katherina Beck +4 more
doaj +1 more source
Protein sequestration versus Hill-type repression in circadian clock models [PDF]
arXiv, 2016 Circadian (~24hr) clocks are self-sustained endogenous oscillators with which organisms keep track of daily and seasonal time. Circadian clocks frequently rely on interlocked transcriptional- translational feedback loops to generate rhythms that are robust against intrinsic and extrinsic perturbations.
arxiv
Mechanism of robust circadian oscillation of KaiC phosphorylation in vitro [PDF]
, 2008 By incubating the mixture of three cyanobacterial proteins, KaiA, KaiB, and KaiC, with ATP in vitro, Kondo and his colleagues reconstituted the robust circadian rhythm of the phosphorylation level of KaiC (Science, 308; 414-415 (2005)). This finding indicates that protein-protein interactions and the associated hydrolysis of ATP suffice to generate the
arxiv +1 more source
Enhanced precision of circadian rhythm by output system [PDF]
arXiv, 2022 Circadian rhythms are biological rhythms of approximately 24 h that persist even under constant conditions without environmental daily cues. The molecular circadian clock machinery generates the physiological rhythms, which can be transmitted into the downstream output system. Owing to the stochastic nature of the biochemical reactions, the oscillation
arxiv
The Anatomical Record, EarlyView.Abstract Hibernation induces significant molecular and cellular adaptations in the retina to maintain function under reduced metabolic conditions. This study aimed to investigate the expression of neuronal, synaptic, and glial markers in the retina of Spermophilus xanthoprymnus during pre‐hibernation and hibernation periods using immunohistochemical ...
Mehmet Özbek +5 more
wiley +1 more source
CRYPTOCHROMES confer robustness, not rhythmicity, to circadian timekeeping
bioRxiv, 2020 Summary Circadian (approximately daily) rhythms are a pervasive property of mammalian cells, tissues, and behaviour, ensuring physiological and metabolic adaptation to solar time.
M. Putker +14 more
semanticscholar +1 more source
Animal Research and One Health, EarlyView.Mechanisms of light in regulating the chick pineal clock. Abstract The circadian clock significantly impacts animal health and productivity, with light playing a crucial role in regulating circadian rhythms. However, the mechanisms behind light‐induced circadian transmission remain unclear, particularly in light‐sensitive avian species.
Yunlei Li +10 more
wiley +1 more source