Results 131 to 140 of about 356,744 (339)

A Joint Pharmacometric Model of Iohexol and Creatinine Administered through a Meat Meal to Assess GFR and Renal OCT2/MATE Activity

Clinical Pharmacology &Therapeutics, EarlyView.
Accurately assessing glomerular filtration rate (GFR) from plasma creatinine concentrations is challenging in patients with unstable renal function. This study aimed to refine the understanding of creatinine kinetics for more reliable assessments of GFR and net creatinine tubular secretion (nCTS) via OCT2/MATE in humans.
Zhendong Chen, Qian Dong, Charalambos Dokos, Jana Boland, Uwe Fuhr, Max Taubert   +5 more
wiley   +1 more source

The Instigation of the Associations Between Melatonin, Circadian Genes, and Epileptic Spasms in Infant Rats

Frontiers in Neurology, 2020
Background: Infantile spasm (IS) is one of the most common catastrophic epilepsy syndromes in infancy characterized by epileptic spasm. While adrenocorticotropic hormone (ACTH) is the first-line treatment for IS, it is evident that the seizures ...
Lin Wan, Xiu-Yu Shi, Wen-Rong Ge, Yu-Lin Sun, Shan Zhang, Jing Wang, Lin-Yan Hu, Li-Ping Zou, Guang Yang   +8 more
doaj   +1 more source

Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth

Science Advances, 2019
We discovered a new CK2 inhibitor and revealed its mechanism of action, connecting the circadian clock and cancer regulation. Compounds targeting the circadian clock have been identified as potential treatments for clock-related diseases, including ...
Tsuyoshi Oshima, Yoshimi Niwa, K. Kuwata, Ashutosh Srivastava, Tomoko Hyoda, Yoshiki Tsuchiya, Megumi Kumagai, M. Tsuyuguchi, T. Tamaru, Akiko Sugiyama, Natsuko Ono, Norjin Zolboot, Y. Aikawa, S. Oishi, A. Nonami, F. Arai, S. Hagihara, Junichiro Yamaguchi, F. Tama, Y. Kunisaki, K. Yagita, M. Ikeda, T. Kinoshita, S. Kay, K. Itami, T. Hirota   +25 more
semanticscholar   +1 more source

The Impact of Redox Mediators on the Electrogenic and Physiological Properties of Synechocystis sp. PCC 6803 in a Biophotovoltaic System

ChemSusChem, EarlyView.
Redox mediators are essential to promote the electrogenic activity of cyanobacteria in biophotovoltaics. In this work, we systematically evaluates three representative mediators about their influence on the cyanobacterial growth, photosynthetic efficiency, and electrogenic activity. The results reveal distinct impacts of different mediators, despite of
Jianqi Yuan, Yu Bai, Claudius Lenz, Vincent Reilly‐Schott, Hans Schneider, Bin Lai, Jens Olaf Krömer   +6 more
wiley   +1 more source

Dissection of central clock function in Drosophila through cell-specific CRISPR-mediated clock gene disruption

eLife, 2019
In Drosophila, ~150 neurons expressing molecular clock proteins regulate circadian behavior. Sixteen of these neurons secrete the neuropeptide Pdf and have been called ‘master pacemakers’ because they are essential for circadian rhythms. A subset of Pdf+
Rebecca Delventhal, Reed M O'Connor, Meghan M Pantalia, Matthew Ulgherait, Han X Kim, Maylis K Basturk, Julie C Canman, Mimi Shirasu-Hiza   +7 more
doaj   +1 more source

Mutation of a PER2 phosphodegron perturbs the circadian phosphoswitch

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance The speed of the circadian clock is regulated by phosphorylation-regulated degradation of the PER protein. However, this model has recently been challenged by genetic studies in mice and fungi.
Shusaku Masuda, Rajesh Narasimamurthy, H. Yoshitane, Jae Kyoung Kim, Y. Fukada, D. Virshup   +5 more
semanticscholar   +1 more source

Lipid and Corticosteroid Biomarkers Under the Influence of Bisphosphonates

Drug Testing and Analysis, EarlyView.
The detection of bisphosphonates is important due to the potential integrity and welfare issues associated with use of these substances. Targeted detection of a nitrogenous and non‐nitrogenous bisphosphonate was detected for 8 h and 28 days post‐administration, respectively.
Kathy Tou, Adam Cawley, Glenys Noble, Jaymie Loy, David Bishop, John Keledjian, Kireesan Sornalingam, Stacey Richards, Shanlin Fu   +8 more
wiley   +1 more source

Clock gene homologs lin-42 and kin-20 regulate circadian rhythms in C. elegans

Scientific Reports
Circadian rhythms are endogenous oscillations in nearly all organisms, from prokaryotes to humans, allowing them to adapt to cyclical environments for close to 24 h. Circadian rhythms are regulated by a central clock, based on a transcription-translation
Melisa L. Lamberti, Rebecca K. Spangler, Victoria Cerdeira, Myriam Ares, Lise Rivollet, Guinevere E. Ashley, Andrea Ramos Coronado, Sarvind Tripathi, Ignacio Spiousas, Jordan D. Ward, Carrie L. Partch, Claire Y. Bénard, M. Eugenia Goya, Diego A. Golombek   +13 more
doaj   +1 more source

Computational modeling of protein interactions and phosphoform kinetics in the KaiABC cyanobacterial circadian clock [PDF]

arXiv, 2014
The KaiABC circadian clock from cyanobacteria is the only known three-protein oscillatory system which can be reconstituted outside the cell and which displays sustained periodic dynamics in various molecular state variables. Despite many recent experimental and theoretical studies there are several open questions regarding the central mechanism(s ...
arxiv  

STIP1 drives Metabolic Reprogramming in Esophageal Squamous Cell Carcinoma via AHCY‐LDHA Axis

Exploration, EarlyView.
A schematic model illustrating that LCA can inhibit ESCC growth by inhibiting the STIP1/AHCY/LDHA axis. In brief. Jin et al. demonstrated that targeting STIP1 can significantly inhibit the progression of esophageal squamous cell carcinoma. The high expression of STIP1 increased the interaction between AHCY and LDHA and then AHCY recruits PRMT3 to ...
Guoguo Jin, Yanming Song, Mingyang Yan, Shaobo Fang, Yang Shao, Kexin Zhao, Meng Liu, Qinxin Guo, Xinyang Jia, Chengjuan Zhang, Zhenwei Wang, Kangdong Liu, Xiang Li, Simin Zhao, Mee‐Hyun Lee, Zhiping Guo, Zigang Dong   +16 more
wiley   +1 more source