Periodic Mechanical Stress Inhibits the Development of Osteoarthritis via Regulating ATF3-Akt Axis [PDF]
Journal of Inflammation Research, 2023 Yi Lou,1,2,* Fanglong Song,3,* Yifan Kang,2 Yaozeng Xu1 1Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Suzhou, 215006, People’s Republic of China; 2Department of Orthopaedics, Shanghai Eastern Hepatobiliary ...
Lou Y, Song F, Kang Y, Xu Y
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Construction of tissue-engineered nucleus pulposus by stimulation with periodic mechanical stress and BMP-2 [PDF]
iScience, 2022 Summary: Intervertebral disc (IVD) degeneration, which is common among elderly individuals, mainly manifests as low back pain and is caused by structural deterioration of the nucleus pulposus (NP) due to physiological mechanical stress.
Yang Liu +3 more
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Proteomic Analysis Reveals a New Benefit of Periodic Mechanical Stress on Chondrocytes [PDF]
Cellular Physiology and Biochemistry, 2017 Background/Aims: In recent years, a variety of studies have been performed to investigate the cellular responses of periodic mechanical stress. In our previous studies, we found that periodic mechanical stress can promote proliferation and matrix ...
Zeng Li +4 more
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Periodic Mechanical Stress Stimulates the FAK Mitogenic Signal in Rat Chondrocytes Through ERK1/2 Activity [PDF]
Cellular Physiology and Biochemistry, 2013 Background/Aims: The biological effects of periodic mechanical stress on chondrocytes have been studied extensively over the past few years. However, the mechanisms underlying chondrocyte mechanosensing and signaling in response to periodic mechanical ...
Wenwei Liang +6 more
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Periodic Mechanical Stress INDUCES Chondrocyte Proliferation and Matrix Synthesis via CaMKII-Mediated Pyk2 Signaling [PDF]
Cellular Physiology and Biochemistry, 2017 Background/Aims: Periodic mechanical stress can promote chondrocyte proliferation and matrix synthesis to improve the quality of tissue-engineered cartilage. Although the integrin β1–ERK1/2 signal cascade has been implicated in periodic mechanical stress-
Wenwei Liang +10 more
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Cross-polarization coupling in polarization maintaining fiber induced by periodic mechanical stress [PDF]
Научно-технический вестник информационных технологий, механики и оптики, 2023 One of the applications of polarization maintaining (PM) fibers is the creation of various sensors including level and hydrostatic pressure sensors. An external mechanical stress on a PM fiber causes cross-polarization coupling.
E. E. Kalugin +3 more
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Periodic Mechanical Stress Stimulates GIT1-Dependent Mitogenic Signals in Rat Chondrocytes Through ERK1/2 Activity [PDF]
Cellular Physiology and Biochemistry, 2018 Background/Aims: The mitogenic effects of periodic mechanical stress on chondrocytes have been studied extensively, but the mechanisms whereby chondrocytes sense and respond to mechanical stimuli remain to be determined.
Kewei Ren +6 more
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Integrin β1 Gene Therapy Enhances in Vitro Creation of Tissue-Engineered Cartilage Under Periodic Mechanical Stress [PDF]
Cellular Physiology and Biochemistry, 2015 Background/Aims: Periodic mechanical stress activates integrin β1-initiated signal pathways to promote chondrocyte proliferation and matrix synthesis. Integrin β1 overexpression has been demonstrated to play important roles in improving the activities ...
Wenwei Liang +9 more
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Effects of periodic mechanical stress on cytoskeleton dependent lipid raft-induced integrin ɑ1 activation in rat nucleus pulposus cells. [PDF]
J Mol Histol, 2023 AbstractExtracellular matrix (ECM) production and nucleus pulposus (NP) cell migration increase under periodic mechanical stress (PMS), but the underpinning regulatory mechanism remains unclear. This work aimed to examine the regulatory effects of cytoskeleton-lipid raft-integrin α1 signaling in NP cells exposed to PMS.
Gao G +9 more
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Proteomic Analysis Reveals Grb2 as a Key Regulator of Periodic Mechanical Stress Transduction in Chondrocytes [PDF]
Cellular Physiology and Biochemistry, 2017 Background/Aims: Periodic mechanical stress could significantly promote chondrocyte proliferation and matrix synthesis. However, the mechanisms underlying the ability of chondrocyte detecting and responding to periodic mechanical stimuli have not been ...
Shun Xu +6 more
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