Results 11 to 20 of about 245,039 (267)

Periodic mechanical stress activates MEK1/2-ERK1/2 mitogenic signals in rat chondrocytes through Src and PLCγ1 [PDF]

Brazilian Journal of Medical and Biological Research, 2011
The mitogenic effects of periodic mechanical stress on chondrocytes have been studied extensively but the mechanisms whereby chondrocytes sense and respond to periodic mechanical stress remain a matter of debate.
Kewei Ren, Yimin Ma, Yumin Huang, Wenwei Liang, Feng Liu, Qing Wang, Weiding Cui, Zhengyu Liu, Guoyong Yin, Weimin Fan   +9 more
doaj   +7 more sources

Periodic Mechanical Stress Activates PKCδ-Dependent EGFR Mitogenic Signals in Rat Chondrocytes via PI3K-Akt and ERK1/2 [PDF]

Cellular Physiology and Biochemistry, 2016
Background/Aims: The present study aimed to analyze the mechanisms by which periodic mechanical stress is translated into biochemical signals, and to verify the important role of signaling molecules including phosphatidylinositol-3-kinase (PI3K)-Akt ...
Peng He, Nan Shen, Gongming Gao, Xuefeng Jiang, Huiqing Sun, Dong Zhou, Nanwei Xu, Luming Nong, Kewei Ren   +8 more
doaj   +4 more sources

Periodic Mechanical Stress Stimulates Cav-1-Dependent IGF-1R Mitogenic Signals in Rat Chondrocytes Through ERK1/2 [PDF]

Cellular Physiology and Biochemistry, 2018
Background/Aims: The biological effects of periodic mechanical stress on the mitogenesis of chondrocytes have been studied extensively over the past few years.
Kewei Ren, Jilei Tang, Xuefeng Jiang, Huiqing Sun, Luming Nong, Nan Shen, Yanqing Gu   +6 more
doaj   +4 more sources

Periodic Mechanical Stress Induces Extracellular Matrix Expression and Migration of Rat Nucleus Pulposus Cells Through Src-GIT1-ERK1/2 Signaling Pathway [PDF]

Cellular Physiology and Biochemistry, 2018
Background/Aims: Periodic mechanical stress has been shown to promote extracellular matrix (ECM) synthesis and cell migration of nucleus pulposus (NP) cells, however, the mechanisms need to be fully elucidated.
Gongming Gao, Haibo Li, Yongjing Huang, Jianjian Yin, Yuqing Jiang, Nanwei Xu, Dong Zhou, Luming Nong, Kewei Ren   +8 more
doaj   +2 more sources

Structural Analysis of Periodic Trusses and Lattice Materials: States of Self-Stress, Mechanisms, and Mechanical Properties

Journal of Applied Mechanics, 2023
Abstract In the realm of low relative density, a rigid-jointed lattice material exhibits a mechanical response analogous to that of a pin-jointed periodic truss with an identical micro-architecture. This correspondence simplifies the evaluation of the lattice’s structural performance. While established matrix methods in linear algebra
Oguz Aycan Ickin, Cihan Tekoğlu
openalex   +2 more sources

Periodic mechanical stress promotes wound healing in osteoarthritic joints through ATF3 suppression and Akt activation

Asian Journal of Surgery
Tianliang Chen, Guilan Li, Yongtao Xu, Bolai Chen   +3 more
doaj   +3 more sources

Periodic mechanical stress activates MEK1/2-ERK1/2 mitogenic signals in rat chondrocytes through Src and PLCγ1

Brazilian Journal of Medical and Biological Research, 2011
The mitogenic effects of periodic mechanical stress on chondrocytes have been studied extensively but the mechanisms whereby chondrocytes sense and respond to periodic mechanical stress remain a matter of debate.
Kewei Ren, Yimin Ma, Yumin Huang, Wenwei Liang, Feng Liu, Qing Wang, Weiding Cui, Zhengyu Liu, Guoyong Yin, Weimin Fan   +9 more
doaj   +1 more source

Periodic mechanical stress enhances rat chondrocyte area expansion and migration through Src-PLCγ1-ERK1/2 signaling

European Journal of Cell Biology, 2010
The signal transduction pathways of chondrocyte area expansion and migration under periodic mechanical stress remain a matter of debate. We explore this question by performing cell culture experiments in our self-developed periodic stress field and perfusion culture system.
Luming Nong, Guoyong Yin, Kewei Ren, Jilei Tang, Weimin Fan   +4 more
openalex   +3 more sources

Impact of Geometry on the Thermal and Mechanical Properties of Periodic Surface Structures: A Numerical Study [PDF]

MATEC Web of Conferences, 2022
Periodic Surface Structures (PSS) fabricated via Additive Manufacturing (AM) have recently emerged as being appropriate candidates for high-value engineered structures.
Gawrońska Elżbieta, Dyja Robert
doaj   +1 more source

Glucocorticoid‐sensitive period of corticotroph development—Implications for mechanisms of early life stress

Journal of Neuroendocrinology, 2023
Abstract Corticotrophs are intermediaries in the hypothalamic–pituitary–adrenal (HPA) axis, which plays a crucial role in stress response in vertebrates. The HPA axis displays an intricate mode of negative feedback regulation, whereby the peripheral effector, cortisol inhibits the secretion of its upstream regulator ...
Guy Peles, Amrutha Swaminathan, Gil Levkowitz   +2 more
openaire   +2 more sources