Results 81 to 90 of about 231,424 (276)

Effect of heat treatment on compression properties of the 316L diamond structure fabricated through selective laser melting

Journal of Materials Research and Technology, 2023
Designing a triply periodic minimal surface (TPMS) lattice structure is a new method for lightweight. Compared with the previous foam- and strut-based structure, the TPMS lattice structure has the advantages of precise control of mechanical properties ...
Zhonghua Li, Zezhou Kuai, Jiaxin Li, Bin Liu, Miao Zhao, Zhicheng Yang, Fei Liu, PeiKang Bai, Wenjuan Huo   +8 more
doaj  

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

Hierarchical nanomechanics of collagen microfibrils [PDF]

, 2010
Collagen constitutes one third of the human proteome, providing mechanical stability, elasticity and strength to connective tissues. Collagen is also the dominating material in the extracellular matrix (ECM) and is thus crucial for cell differentiation ...
Alberto Redaelli, Alfonso Gautieri, Markus J. Buehler, Simone Vesentini   +3 more
core   +2 more sources

Extreme mechanical resilience of self-assembled nanolabyrinthine materials [PDF]

, 2020
Low-density materials with tailorable properties have attracted attention for decades, yet stiff materials that can resiliently tolerate extreme forces and deformation while being manufactured at large scales have remained a rare find.
Greer, Julia R., Kochmann, Dennis M., Krödel, Sebastian, Portela, Carlos M., Vidyasagar, A., Weissenbach, Tamara, Yee, Daryl W.   +6 more
core   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Numerical investigation of the mechanical properties of lattice structures inspired from polycrystalline materials

AIP Advances
In this work, polycrystalline-like lattice structures that are inspired by the geometry of polycrystalline materials are designed. They are generated by filling periodic lattice structures into a Voronoi diagram.
Yabo Liu, Guangwei Bai, Zhipeng Qu, Xiaochang Xu   +3 more
doaj   +1 more source

Short peptide perturbs spermatogenesis via immune microenvironment dysregulation and mitochondrial imbalance

FEBS Open Bio, EarlyView.
In the blood–testis barrier, occludin is crucial for tight junctions. This study demonstrates that occludin‐targeting short peptides disrupt junction integrity, inducing immune cell infiltration, tumor necrosis factor‐α/interleukin‐6 secretion and mitochondrial dysfunction, ultimately triggering apoptosis.
Heng Wang, Xiaofang Tan, Deyu Chen
wiley   +1 more source

Mechanically induced topological transition of spectrin regulates its distribution in the mammalian cell cortex

Nature Communications
The cell cortex is a dynamic assembly formed by the plasma membrane and underlying cytoskeleton. As the main determinant of cell shape, the cortex ensures its integrity during passive and active deformations by adapting cytoskeleton topologies through ...
Andrea Ghisleni, Mayte Bonilla-Quintana, Michele Crestani, Zeno Lavagnino, Camilla Galli, Padmini Rangamani, Nils C. Gauthier   +6 more
doaj   +1 more source

Investigation of mechanical responses to the tactile perception of surfaces with different textures using the finite element method

Advances in Mechanical Engineering, 2016
Tactile perception is essential for humans to perceive the world, and it usually results in mechanical responses from the finger. In this study, a nonlinear, viscoelastic, and multilayered finite element model of the finger was developed.
Wei Tang, Jiankai Zhang, Xiaolu Shi, Shaogang Zhang, Songyong Liu, Hua Zhu, Shirong Ge   +6 more
doaj   +1 more source

Structure-Enhanced Mechanically Robust Graphite Foam with Ultrahigh MnO2 Loading for Supercapacitors

Research, 2020
With the fast bloom of flexible electronics and green vehicles, it is vitally important to rationally design and facilely construct customized functional materials with excellent mechanical properties as well as high electrochemical performance.
Qinghe Cao, Junjie Du, Xiaowan Tang, Xi Xu, Longsheng Huang, Dongming Cai, Xu Long, Xuewen Wang, Jun Ding, Cao Guan, Wei Huang   +10 more
doaj   +1 more source