Results 81 to 90 of about 245,039 (267)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Numerical investigation of the mechanical properties of lattice structures inspired from polycrystalline materials

AIP Advances
In this work, polycrystalline-like lattice structures that are inspired by the geometry of polycrystalline materials are designed. They are generated by filling periodic lattice structures into a Voronoi diagram.
Yabo Liu, Guangwei Bai, Zhipeng Qu, Xiaochang Xu   +3 more
doaj   +1 more source

Effect of Boundary Constraints on the Nonlinear Flapping of Filaments Animated by Follower Forces

, 2019
Elastically driven filaments subjected to animating compressive follower forces provide a synthetic way to mimic the oscillatory beating of active biological filaments such as eukaryotic cilia.
Fatehiboroujeni, Soheil, Gopinath, Arvind, Goyal, Sachin   +2 more
core  

Mechanical properties of polycrystalline graphene based on a realistic atomistic model

, 2012
Graphene can at present be grown at large quantities only by the chemical vapor deposition method, which produces polycrystalline samples. Here, we describe a method for constructing realistic polycrystalline graphene samples for atomistic simulations ...
B. I. Yakobson, Jani Kotakoski, Jannik C. Meyer   +2 more
core   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Stress strain curve analysis of sheet based TPMS structures in quasi static compression test: A review

Journal of Materials Research and Technology
Stress-strain behaviour of Triply Periodic Minimal Surface (TPMS) structures presents challenges in predicting their mechanical properties. Current studies are hindered by limitations in modelling its complex geometries.
Izzat Mat Samudin, Nabilah Afiqah Mohd Radzuan, Abu Bakar Sulong, Quanjin Ma, Abdul Hadi Azman, Wan Fathul Hakim Wan Zamri   +5 more
doaj   +1 more source

Local and non-local normalised equivalent strain functionals for cyclic fatigue [PDF]

, 2004
The concept of Cyclic Normalised Equivalent Strain Functionals (CNESnFs) suitable for lowcyclic fatigue is developed in this paper. It reduces any fatigue strength and durability model to a unique form what facilitates the models comparison ...
Mikhailov, SE, Namestnikova, IV
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Mechanically induced topological transition of spectrin regulates its distribution in the mammalian cell cortex

Nature Communications
The cell cortex is a dynamic assembly formed by the plasma membrane and underlying cytoskeleton. As the main determinant of cell shape, the cortex ensures its integrity during passive and active deformations by adapting cytoskeleton topologies through ...
Andrea Ghisleni, Mayte Bonilla-Quintana, Michele Crestani, Zeno Lavagnino, Camilla Galli, Padmini Rangamani, Nils C. Gauthier   +6 more
doaj   +1 more source

Nature-inspired heterogeneous metamaterials: functional design framework

Materials & Design
Heterogeneous mechanical metamaterials can achieve extraordinary properties through their complex and diverse microstructural designs. However, research on the functional realization by heterogeneous mechanical metamaterials in varying scenarios remains ...
Zhuo Chen, Huitian Wang, Zihan Hu, Limin Zhou, Yiu Wing Mai, Robert O. Ritchie, Sha Yin   +6 more
doaj   +1 more source