Results 71 to 80 of about 41,765 (241)

Effect of uniaxial compressive stress on polarization switching and domain wall formation in tetragonal phase BaTiO3 via machine learning potential

Materials & Design
Ferroelectric materials such as BaTiO3 exhibit spontaneous polarization that can be reoriented by an external electric field, forming the basis of a wide range of memory, actuator, and sensor applications.
Poyen Chen, Teruyasu Mizoguchi
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Distinctive mechanical responses of strut-based and triply periodic minimal surface (TPMS) Ti-6Al-4V diamond lattice structures produced by electron beam melting

Metals Advances
Lattice structures exhibit exceptional specific strength and energy absorption, making them ideal for aerospace and biomedical applications. While both strut-based (Strut-D) and TPMS-based (triply periodic minimal surface-D) diamond lattice structures ...
Li-Na Zhang, Yu Guo, Wu Pan, Wen-Ge Xu, Cheng-Long Teng, Rui-Feng Li, Sheng Lu, Liang-Yu Chen   +7 more
doaj   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Design of novel non-periodic biomimetic bone scaffolds using the Moving Morphable Components method

Materials & Design
Bone scaffolds are widely used in orthopedics for tissue repair and regeneration, yet achieving optimal bone growth through porous scaffolds remains a significant challenge.
Hao Wang, Jiongyi Wu, Yuhang Chen, Michael Zhuravkov, Sergei Bosiakov, Youwei Zhang, Mohammed Rafiq Abdul Kadir, Jian Jiang, Yongtao Lyu   +8 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Hydro‐Mechanical Controls on Swarm Recurrence on the Westernmost Gofar Transform Fault, East Pacific Rise

Geophysical Research Letters
Swarms are microearthquake clusters governed by aseismic deformation, fluid migration, and stress changes, but the underlying mechanisms for their recurrence remain elusive. In 2008, abundant swarms were observed on the westernmost Gofar transform fault.
Lintong Jiang, Shihuai Zhang, Xiaying Li
doaj   +1 more source

Investigation of mechanical responses to the tactile perception of surfaces with different textures using the finite element method

Advances in Mechanical Engineering, 2016
Tactile perception is essential for humans to perceive the world, and it usually results in mechanical responses from the finger. In this study, a nonlinear, viscoelastic, and multilayered finite element model of the finger was developed.
Wei Tang, Jiankai Zhang, Xiaolu Shi, Shaogang Zhang, Songyong Liu, Hua Zhu, Shirong Ge   +6 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source