Results 51 to 60 of about 2,457 (181)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Cross-polarization coupling in polarization maintaining fiber induced by periodic mechanical stress

Научно-технический вестник информационных технологий, механики и оптики
One of the applications of polarization maintaining (PM) fibers is the creation of various sensors including level and hydrostatic pressure sensors. An external mechanical stress on a PM fiber causes cross-polarization coupling.
E. E. Kalugin, V. E. Strigalev, A. B. Mukhtubaev, I. K. Meshkovskii   +3 more
doaj   +1 more source

Insights into the mechanical properties of several triply periodic minimal surface lattice structures made by polymer additive manufacturing [PDF]

, 2017
Three-dimensional lattices have applications across a range of fields including structural lightweighting, impact absorption and biomedicine. In this work, lattices based on triply periodic minimal surfaces were produced by polymer additive manufacturing
Williams, C.B., R.J.M. Hague, Aremu, Adedeji, A. Panesar, Panesar, Ajit, Wildman, RD, L. Sturm, Panesar, A., Maskery, I, Williams, CB, Ashcroft, Ian, C.J. Tuck, Wildman, Ricky, Maskery, I., Hague, Richard J.M., Hague, Richard, Wildman, R. D., Tuck, Christopher, Sturm, L, Hague, RJM, Tuck, C. J., Williams, C. B., Maskery, Ian, Tuck, Chris, Aremu, Adedeji; id_orcid, Tuck, CJ, Ashcroft, IA, R.D. Wildman, I. Maskery, Sturm, L., Aremu, A. O., Panesar, A, Wildman, Ricky D., Ashcroft, I. A., I.A. Ashcroft, C.B. Williams, A.O. Aremu, Hague, R. J. M., Aremu, AO   +38 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Modulate stress distribution with bio-inspired irregular architected materials towards optimal tissue support

Nature Communications
Natural materials typically exhibit irregular and non-periodic architectures, endowing them with compelling functionalities such as body protection, camouflage, and mechanical stress modulation.
Yingqi Jia, Ke Liu, Xiaojia Shelly Zhang
doaj   +1 more source

Determination of cellular strains by combined atomic force microscopy and finite element modeling

, 2002
Many organs adapt to their mechanical environment as a result of physiological change or disease. Cells are both the detectors and effectors of this process.
Charras, GT, Charras, Guillaume T., Horton, MA, Horton, Mike A.   +3 more
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Novel mechanical behavior of periodic structure with the pattern transformation

, 2013
In periodic cellular structures, novel pattern transformations are triggered by a reversible elastic instability under the axial compression. Based on the deformation-triggered new pattern, periodic cellular structures can achieve special mechanical ...
He, Yuhao, Lei, Jincheng, Hu, Jianying, Liu, Zishun   +3 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Mechanical properties of AlSi10Mg lattice structures fabricated by selective laser melting

Materials & Design, 2020
Al alloy porous structures have potential application in industries such as light aerospace and some heat exchanger products. A particular advantage of selective laser melting (SLM) over conventional manufacturing processes is its ability to fabricate ...
Zhong-hua Li, Yun-fei Nie, Bin Liu, Ze-zhou Kuai, Miao Zhao, Fei Liu   +5 more
doaj   +1 more source