Results 61 to 70 of about 2,457 (181)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Influence of deformed primitive architecture on mechanical behavior of artificial porous meniscus

open access: yesMaterials & Design, 2020
Polycarbonate urethane (PCU) has emerged as a suitable material for artificial meniscus replacement after meniscectomy. However, the commercial PCU meniscal replacements could not reproduce native meniscus performance until now. The aim of this paper was
Li-ya Zhu   +5 more
doaj   +1 more source

Stress Field Analysis of Mode II Periodic Cracks-Tip

open access: yes, 2011
The cracks-tip field on ModeⅡperiodic cracks of infinite orthotropic fiber reinforcement composite plate subjected to the concentrated force was studied.
Jian Zhang   +3 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Numerical investigation of the mechanical properties of lattice structures inspired from polycrystalline materials

open access: yesAIP Advances
In this work, polycrystalline-like lattice structures that are inspired by the geometry of polycrystalline materials are designed. They are generated by filling periodic lattice structures into a Voronoi diagram.
Yabo Liu   +3 more
doaj   +1 more source

Stress strain curve analysis of sheet based TPMS structures in quasi static compression test: A review

open access: yesJournal of Materials Research and Technology
Stress-strain behaviour of Triply Periodic Minimal Surface (TPMS) structures presents challenges in predicting their mechanical properties. Current studies are hindered by limitations in modelling its complex geometries.
Izzat Mat Samudin   +5 more
doaj   +1 more source

An automated methodology for performing time synchronous averaging of a gearbox signal without speed sensor [PDF]

open access: yes, 2007
In this paper we extend a sensorless algorithm proposed by Bonnardot et al. for angular resampling of the acceleration signal of a gearbox submitted to limited speed fluctuation.
Gelman, Leonid, Combet, Francois
core   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

Mechanically induced topological transition of spectrin regulates its distribution in the mammalian cell cortex

open access: yesNature Communications
The cell cortex is a dynamic assembly formed by the plasma membrane and underlying cytoskeleton. As the main determinant of cell shape, the cortex ensures its integrity during passive and active deformations by adapting cytoskeleton topologies through ...
Andrea Ghisleni   +6 more
doaj   +1 more source

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