Results 81 to 90 of about 2,457 (181)

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Statistical assessment of multiaxial HCF criteria at the grain scale [PDF]

, 2014
Multiaxial high cycle fatigue modeling of materials is an issue that concerns many industrial domains (automotive, aerospace, nuclear, etc.) and in which many progress still remains to be achieved.
PALIN-LUC, Thierry, HOR, Anis, MOREL, Franck, PALIN LUC, Thierry, SAINTIER, Nicolas, ROBERT, Camille   +5 more
core   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Design of novel non-periodic biomimetic bone scaffolds using the Moving Morphable Components method

Materials & Design
Bone scaffolds are widely used in orthopedics for tissue repair and regeneration, yet achieving optimal bone growth through porous scaffolds remains a significant challenge.
Hao Wang, Jiongyi Wu, Yuhang Chen, Michael Zhuravkov, Sergei Bosiakov, Youwei Zhang, Mohammed Rafiq Abdul Kadir, Jian Jiang, Yongtao Lyu   +8 more
doaj   +1 more source

Investigation of mechanical responses to the tactile perception of surfaces with different textures using the finite element method

Advances in Mechanical Engineering, 2016
Tactile perception is essential for humans to perceive the world, and it usually results in mechanical responses from the finger. In this study, a nonlinear, viscoelastic, and multilayered finite element model of the finger was developed.
Wei Tang, Jiankai Zhang, Xiaolu Shi, Shaogang Zhang, Songyong Liu, Hua Zhu, Shirong Ge   +6 more
doaj   +1 more source

STRESS INTENSITY FACTORS FOR CIRCUMFERENTIAL PERIODIC CRACKED PIPES UNDER BENDING

, 2019
Stress intensity factor is an important parameter that characterizes the stress field near the tip in fracture analysis. The simple and effective methods to estimate intensity factor become significant.
XIE YuJun, LIU WanJun
core   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Hydro‐Mechanical Controls on Swarm Recurrence on the Westernmost Gofar Transform Fault, East Pacific Rise

Geophysical Research Letters
Swarms are microearthquake clusters governed by aseismic deformation, fluid migration, and stress changes, but the underlying mechanisms for their recurrence remain elusive. In 2008, abundant swarms were observed on the westernmost Gofar transform fault.
Lintong Jiang, Shihuai Zhang, Xiaying Li
doaj   +1 more source

Mechanical and thermal responses of random triply periodic minimal surface structures

Materials & Design
This study investigates the mechanical and thermal responses of stochastic Triply Periodic Minimal Surface (TPMS) structures fabricated using the laser powder bed fusion process with Ti-6Al-4V.
Maytawee Maneein, Thanakit Yuthchaiming, Chutima Pankul, Atikom Sombatmai, Teerapong Poltue, Vikram Ahuja, Raj Das, Patcharapit Promoppatum   +7 more
doaj   +1 more source