Results 111 to 120 of about 128,153 (317)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

open access: yesFEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang   +9 more
wiley   +1 more source

Automated classification of variable stars for All-Sky Automated Survey 1-2 data [PDF]

open access: yes, 2017
With the advent of surveys generating multi-epoch photometry and the discovery of large numbers of variable stars, the classification of these stars has to be automatic.
Blake, C., Eyer, L.
core  

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

A Comparison of Best Fits Obtained in White Dwarf Asteroseismology Using the WDEC and the LPCODE

open access: yesThe Astrophysical Journal
We perform the asteroseismic fitting of four DAVs using a grid of WDEC models with chemical profiles that closely mimic those of the LPCODE models and compare them with published asteroseismic fitting results using the LPCODE.
Agnès Bischoff-Kim
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Constraints from Parallaxes and Average Period Spacings in the Asteroseismic Study of Eight Hydrogen-atmosphere Pulsating White Dwarfs

open access: yesThe Astrophysical Journal
With space missions such as Kepler, TESS, and Gaia, we have a wealth of data on pulsating white dwarfs that can be leveraged in white dwarf asteroseismology. We address the question of the proportion of white dwarfs with thin hydrogen layers versus those
Agnès Bischoff-Kim, Keaton J. Bell
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

β Cephei Pulsators in Eclipsing Binaries Observed with TESS

open access: yesThe Astrophysical Journal Supplement Series
The combined strength of asteroseismology and empirical stellar basic parameter determinations for in-depth asteroseismic analysis of massive pulsators in eclipsing binaries shows great potential for treating the challenging and mysterious discrepancies ...
Christian I. Eze, Gerald Handler
doaj   +1 more source

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