Results 81 to 90 of about 126,616 (274)

Constraining the Variability and Binary Fraction of Galactic Center Young Stars

, 2016
We present constraints on the variability and binarity of young stars in the central 10 arcseconds (~0.4 pc) of the Milky Way Galactic Center (GC) using Keck Adaptive Optics data over a 12 year baseline.
Chappell, Samantha, Do, Tuan, Gautam, Abhimat K., Ghez, Andrea M., Lu, Jessica R., Morris, Mark R., Sakai, Shoko, Sitarski, Breann N., Witzel, Gunther   +8 more
core   +2 more sources

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Minute-cadence Observations of the Galactic Plane with the Wide Field Survey Telescope (WFST): Overview, Methodology, and Early Results

The Astrophysical Journal Supplement Series
As the time-domain survey telescope of the highest survey power in the Northern Hemisphere currently, the Wide Field Survey Telescope (WFST) is scheduled to hourly/daily/semiweekly scan the Northern sky up to ∼23 mag in four optical ( ugri ) bands ...
Jie Lin, Tinggui Wang, Minxuan Cai, Zhen Wan, Xuzhi Li, Lulu Fan, Qingfeng Zhu, Ji-an Jiang, Ning Jiang, Xu Kong, Zheyu Lin, Jiazheng Zhu, Zhengyan Liu, Jie Gao, Bin Li, Feng Li, Ming Liang, Hao Liu, Wei Liu, Wentao Luo, Jinlong Tang, Hairen Wang, Jian Wang, Yongquan Xue, Dazhi Yao, Hongfei Zhang, Xiaoling Zhang, Wen Zhao, Xianzhong Zheng   +28 more
doaj   +1 more source

Expression and DNA methylation of 20S proteasome subunits as prognostic and resistance markers in cancer

Molecular Oncology, EarlyView.
Comprehensive analysis of genomic mutations, gene expression, DNA methylation, and pathway analysis of TCGA data was carried out to define cancer types in which proteasome subunits expression is associated with worse survival. Albeit the effect of specific proteasome subunits on cellular function, the main role of the proteasome is better evaluated ...
Ruba Al‐Abdulla, Simone Venz, Ruslan Al‐Ali, Martin Wendlandt, Mandy Radefeldt, Elke Krüger   +5 more
wiley   +1 more source

Machine learning for identifying liver and pancreas cancers through comprehensive serum glycopeptide spectra analysis: a case‐control study

Molecular Oncology, EarlyView.
This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima, Yuko Takami, Ken Kawabe, Kazuhiro Tanabe, Chihiro Hayashi, Mikio Mikami, Tetsuya Kusumoto   +6 more
wiley   +1 more source

Phase II of the LAMOST-Kepler/K2 Survey. II. Time Domain of Medium-resolution Spectroscopic Observations from 2018 to 2023

The Astrophysical Journal Supplement Series
The LAMOST-Kepler/K2 Medium-Resolution Spectroscopic Survey (LK-MRS) conducted time-domain (TD) medium-resolution spectroscopic observations of 20 LAMOST plates in the Kepler and K2 fields from 2018 to 2023, a phase designated as LK-MRS-I.
Mingfeng Qin, Jian-Ning Fu, Weikai Zong, Peter De Cat, Antonio Frasca, Tianqi Cang, Jiangtao Wang, Jianrong Shi, Ali Luo, Haotong Zhang, Hongliang Yan, J. Molenda-Żakowicz, R. O. Gray, Jiaxin Wang   +13 more
doaj   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Rotation Periods of Candidate Single Late-M Dwarfs in TESS

The Astronomical Journal
Recent studies suggest that the angular momentum evolution of late-M and brown dwarfs differs from the well-known spin-down evolution of hotter stars. Characterizing the distribution of rotation periods of these objects in the solar neighborhood can help
Samantha Lambier, Stanimir Metchev, Paulo Miles-Páez, Leslie Moranta, Dakota Wolfe, Joelene Hales, Jeffrey Martinovic   +6 more
doaj   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source