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Thyrotropin inhibits osteogenic differentiation of human periodontal ligament stem cells.

Journal of Periodontal Research, 2023
BACKGROUND AND OBJECTIVE Periodontal ligament stem cells (PDLSCs) are derived from the periodontal ligament and have the characteristics of pluripotent differentiation, including osteogenesis, and are one of the important seed cells in oral tissue ...
Yang Zeng   +6 more
semanticscholar   +1 more source

FoxO1 Agonists Promote Bone Regeneration in Periodontitis by Protecting the Osteogenesis of Periodontal Ligament Stem Cells

Stem Cells and Development, 2023
Protecting the function of periodontal ligament stem cells (PDLSCs) is crucial for bone regeneration in periodontitis. Forkhead box protein O1 (FoxO1) has been previously reported as a crucial mediator in bone homeostasis, providing a favorable ...
Xiaojun Huang   +6 more
semanticscholar   +1 more source

Periodontal ligament stem cells in the periodontitis niche: inseparable interactions and mechanisms

Journal of Leukocyte Biology, 2021
Periodontitis is characterized by the periodontium's pathologic destruction due to the host's overwhelmed inflammation to the dental plaque. The bacterial infections and subsequent host immune responses have shaped a distinct microenvironment, which ...
Zhiyu Zhang   +3 more
semanticscholar   +1 more source

Biological interactions between calcium silicate-based endodontic biomaterials and periodontal ligament stem cells: A systematic review of in vitro studies.

International Endodontic Journal, 2021
BACKGROUND Most recently, the biological interactions, i.e. cytocompatibility, cell differentiation and mineralization potential, between calcium-silicate based biomaterials and periodontal ligament stem cells (PDLSCs) has been studied at an in vitro ...
J. Sanz   +4 more
semanticscholar   +1 more source

Epigenetic regulation of osteogenic differentiation of periodontal ligament stem cells in periodontitis.

Oral Diseases, 2022
OBJECTIVES Periodontitis is an inflammatory disease characterized by alveolar bone loss. Periodontal ligament stem cells (PDLSCs) have osteogenic differentiation potential, which can be influenced by epigenetics regulation in periodontitis.
Jingwei Cao   +5 more
semanticscholar   +1 more source

Lactate inhibits osteogenic differentiation of human periodontal ligament stem cells via autophagy through the MCT1-mTOR signaling pathway.

Bone, 2022
BACKGROUND Periodontal ligament stem cells (PDLSCs) play a crucial role in periodontal bone regeneration. Lactate used to be considered a waste product of glucose metabolism.
Ying-Ying Luo   +5 more
semanticscholar   +1 more source

Exosomal circ_0000722 derived from periodontal ligament stem cells undergoing osteogenic differentiation promotes osteoclastogenesis.

International Immunopharmacology
Periodontal ligament stem cells (PDLSCs), which are considered promising stem cells for regeneration of periodontal bony tissue, can also manipulate alveolar bone remodeling by exosomes.
Liang-Kun Xie   +6 more
semanticscholar   +1 more source

Curcumin reduces apoptosis and promotes osteogenesis of human periodontal ligament stem cells under oxidative stress in vitro and in vivo.

Life Science, 2021
AIMS Human periodontal ligament stem cells (hPDLSCs) tether the teeth to the surrounding bone and are considered as major functional stem cells responsible for regeneration of the alveolar bone and periodontal ligament tissue.
Lingping Tan   +7 more
semanticscholar   +1 more source

Characteristics and biologic effects of thermosensitive quercetin-chitosan/collagen hydrogel on human periodontal ligament stem cells.

Journal of Biomedical Materials Research. Part B - Applied biomaterials, 2021
Thermosensitive hydrogels could function as scaffolds and delivery vehicle of natural flavonoids. The current study aimed to investigate effects of chitosan/collagen ratios on properties of thermosensitive beta-glycerophosphate (bGP) chitosan/collagen ...
P. Arpornmaeklong   +3 more
semanticscholar   +1 more source

Periodontal Ligament Stem Cells: Regenerative Potency in Periodontium

Stem Cells and Development, 2019
Periodontium is consisted of root cementum, bone lining the tooth socket, gingiva facing the tooth, and periodontal ligament (PDL). Its primary functions are support of the tooth and protection of tooth, nerve, and blood vessels from injury by mechanical
Atsushi Tomokiyo, N. Wada, H. Maeda
semanticscholar   +1 more source

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