Results 41 to 50 of about 24,844 (245)

Recent advances in periodontal regeneration: A biomaterial perspective

Bioactive Materials, 2020
Periodontal disease (PD) is one of the most common inflammatory oral diseases, affecting approximately 47% of adults aged 30 years or older in the United States.
Yongxi Liang, Xianghong Luan, Xiaohua Liu   +2 more
doaj   +1 more source

Biomaterials for periodontal regeneration: A brief overview

Journal of Oral Research and Review, 2021
The aim of periodontal regenerative therapy is to restore the original architecture and function of lost periodontal tissues as a result of trauma or following destructive periodontal diseases.
Dhiraj B Dufare
doaj   +1 more source

Distinct Immunomodulatory Strategies Guide Mesenchymal Stromal/Stem Cell‐Mediated Bone Regeneration

Advanced Science, EarlyView.
Bone regeneration by mesenchymal stem cells is strongly influenced by immune signals. This study shows that priming stem cells with regulatory immune cells or an inflammation‐resolving lipid molecule enhances bone formation through distinct immune pathways.
Salwa Suliman, Carla Alvarez Rivas, Aashish Srivastava, Nora Marek, Kamal Mustafa, Alpdogan Kantarci   +5 more
wiley   +1 more source

Sensory Nerve‐Derived CGRP Controls Osteoclastogenesis by Limiting Macrophage Bioenergetics in Bone Repair

Advanced Science, EarlyView.
Sensory nerves help bones heal. This study shows that the neuropeptide CGRP, released from sensory nerves, slows down macrophage energy production, preventing excessive bone breakdown. By revealing this nerve–immune–metabolism connection, the work provides new insight into how the body balances bone repair and opens doors to targeted treatments ...
Jiaying Liu, Ting Zhang, Yuqing Mu, Lili Li, Ju Jin, Kevin J Dudley, Wendong Gao, Donglin Cai, Fuhua Yan, Lan Xiao, Yin Xiao   +10 more
wiley   +1 more source

Periodontal Wound Healing and Regeneration: Insights for Engineering New Therapeutic Approaches

Frontiers in Dental Medicine, 2022
Periodontitis is a widespread inflammatory disease that leads to loss of the tooth supporting periodontal tissues. The few therapies available to regenerate periodontal tissues have high costs and inherent limitations, inspiring the development of new ...
David Fraser, David Fraser, Jack Caton, Danielle S. W. Benoit, Danielle S. W. Benoit, Danielle S. W. Benoit, Danielle S. W. Benoit, Danielle S. W. Benoit   +7 more
doaj   +1 more source

Identification of a Force‐Induced Sox9+Acan+ Transitional Subpopulation Linked to FGF2–FGFR2–ERK Signaling in Orthodontic Bone Remodeling

Advanced Science, EarlyView.
Mechanical loading induces a previously unrecognized Sox9+Acan+ transitional mesenchymal cell population in the periodontal ligament that promotes osteoclastogenesis via the FGF2–FGFR2–ERK axis. Targeting this mechanoresponsive stromal population using a localized GelMA@siRNA delivery strategy attenuates pathological osteoclast overactivation and root ...
Miao Tan, Minyu He, Mingrui Zong, Qiya Tang, Yinan Liu, Jiaju Deng, Shun Huang, Xiaoxiao Lei, Jie Li, Lan Huang   +9 more
wiley   +1 more source

Nanocrystalline hydroxyapatite in periodontal bone regeneration: A systematic review

Saudi Dental Journal, 2022
Background: Periodontal diseases when persistent, results in periodontal pockets, attachment loss and progressive destruction of the alveolar bone.
Marwa Y. Shaheen
doaj   +1 more source

Endothelial PDGF Signaling Dysregulation Impairs Testicular Interstitial Homeostasis in Diabetes

Advanced Science, EarlyView.
Testicular endothelial cells (TECs) function as central signaling hubs that coordinate interstitial homeostasis. Diabetes disrupts TEC‐derived PDGF signaling, silences the JUND‐MCL1 survival program in Leydig cells, and impairs peritubular function, leading to fibrosis and testosterone insufficiency.
Wenxiu Zhang, Kai Hong, Yanling Tang, Lina Cui, Xiaojian Lu, Jianxing Cheng, Yangyi Fang, Qiaoling Jiang, Ziyan Zhuang, Songzhan Gao, Hui Jiang, Qiang Liu, Jingtao Guo, Zhe Zhang, Xiaoyan Wang   +14 more
wiley   +1 more source

Antimicrobial Efficacy and Soft-Tissue Safety of Air-Polishing Powders in Periodontal Therapy: A Narrative Review

Journal of Functional Biomaterials
Periodontitis is a biofilm-induced multifactorial disease characterized by non-reversible damage of the periodontal tissues. Dysbiosis of the subgingival microbiota plays a crucial role in periodontitis. In this regard, conventional periodontal treatment
Ștefania Sorina Ifrim, Alina Bârdea, Alexandra Roman, Andrada Soancă, Silviu Albu, Anda Gâta, Carmen Silvia Caloian, Andreea Cândea   +7 more
doaj   +1 more source

Cascade Therapy of Periodontitis via Sequential Release of Ribosome‐Targeting Antimicrobial Peptide and Irisin From a Multifunctional MOF‐Based System

Advanced Science, EarlyView.
This study presents a novel strategy for periodontitis treatment by co‐delivering a membrane‐ and ribosome‐targeting antimicrobial peptide GF and Irisin through a pH‐responsive metal‐organic framework. The system enables sequential release, providing rapid antibacterial action, anti‐inflammatory and antioxidative effects, as well as promoting bone ...
Yan Chen, Zheng Xu, Yunmo Xue, Shanshan Liu, Xiang Zhang, Jingyao Guo, Minhui Yao, Yue Liu, Xiaolin Lu, Jieshu Qian, Qian Ma   +10 more
wiley   +1 more source