Results 71 to 80 of about 1,864,506 (312)

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

Dysregulation of NAD+ metabolism induces a Schwann cell dedifferentiation program [PDF]

, 2018
The Schwann cell (SC) is the major component of the peripheral nervous system (PNS) that provides metabolic and functional support for peripheral axons. The emerging roles of SC mitochondrial function for PNS development and axonal stability indicate the
Hackett, Amber R, Kim, Sungsu, Milbrandt, Jeffrey, Sasaki, Yo, Strickland, Amy   +4 more
core   +1 more source

Predicting adverse events after thoracic endovascular aortic repair for patients with type B aortic dissection

Scientific Reports
The potential of adverse events (AEs) after thoracic endovascular aortic repair (TEVAR) in patients with type B aortic dissection (TBAD) has been reported.
Mengyang Kang, You Li, Yiman Zhang, Yang Zhao, Yan Meng, Junbo Zhang, Hongyan Tian   +6 more
doaj   +1 more source

Lumbosacral Plexogram: An Aid to Reconstructive Nerve Possibilities in the Lower Extremity

Plastic and Reconstructive Surgery, Global Open
Summary:. The lumbosacral plexus is the network of nerves responsible for the motor and sensory function of the pelvis and lower limb. Our observation is that the anatomy of this plexus is less familiar to surgeons than that of the brachial plexus ...
Sami Ramadan, FRCS(Plast), Catherine Leng, MRCS, Liron S. Duraku, MD, PhD, Tahseen Chaudhry, FRCS(Tr&Orth), Dominic M. Power, FRCS(Tr&Orth), Samuel George, FRCS(Plast)   +5 more
doaj   +1 more source

Diasystème et diglossie périphérique : le « cas gallo-roman »

La Bretagne Linguistique, 1998
Based on a corpus analysis of the Poitevin language, this article explores the diasystemic relationship that unites Oïl varieties both with each other and with reference French.
Jean Léo Léonard
doaj   +1 more source

Communications Between Peripheral and the Brain-Resident Immune System in Neuronal Regeneration After Stroke

Frontiers in Immunology, 2020
Cerebral ischemia may cause irreversible neural network damage and result in functional deficits. Targeting neuronal repair after stroke potentiates the formation of new connections, which can be translated into a better functional outcome.
Fangxi Liu, Xi Cheng, Shanshan Zhong, Chang Liu, Jukka Jolkkonen, Xiuchun Zhang, Yifan Liang, Zhouyang Liu, Chuansheng Zhao, Chuansheng Zhao   +9 more
doaj   +1 more source

Shear-Wave-Elastography in Neurofibromatosis Type I

Diagnostics, 2022
Ultrasound shear wave elastography (SWE) is an increasingly used imaging modality that expands clinical ultrasound by measuring the elasticity of various tissues, such as the altered elasticity of tumors.
Deborah Staber, Julia Oppold, Alexander Grimm, Martin U. Schuhmann, Alyssa Romano, Justus Marquetand, Benedict Kleiser   +6 more
doaj   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

A Population-Based Ultra-Widefield Digital Image Grading Study for Age-Related Macular Degeneration-Like Lesions at the Peripheral Retina. [PDF]

, 2015
Our understanding of the relevance of peripheral retinal abnormalities to disease in general and in age-related macular degeneration (AMD) in particular is limited by the lack of detailed peripheral imaging studies.
Bird, AC, Csutak, A, Florea, D, Jonasson, F, Lengyel, I, Leung, I, Peto, T   +6 more
core   +1 more source

Management of peripheral ossifying fibroma due to severe periodontitis: Case report [PDF]

Balkan Journal of Dental Medicine
Background/Aim: Peripheral ossifying fibroma (POF) constitutes a common reactive lesion of the gingiva, most commonly localized in the anterior maxillary region.
Zisis Stefanos, Zisi Vasileios, Shinas Nikolaos, Poulopoulos Konstantinos, Charisi Christina, Papadopoulos Petros, Kyriakou Nikolaos, Cordahi Joe, Anagnostou Eleftherios, Poulopoulos Athanasios   +9 more
doaj   +1 more source