Results 71 to 80 of about 3,916,297 (351)

The Function of MicroRNAs in B-Cell Development, Lymphoma, and Their Potential in Clinical Practice

Frontiers in Immunology, 2018
B-cell formation, development, and differentiation are complex processes regulated by several mechanisms. Recently, there has been growing evidence indicating that microRNAs (miRNAs) are important for normal B-cell lineage development.
Bing Zheng, Bing Zheng, Zhijiang Xi, Zhijiang Xi, Rong Liu, Rong Liu, Wei Yin, Zhiwei Sui, Boxu Ren, Boxu Ren, Heather Miller, Quan Gong, Quan Gong, Chaohong Liu   +13 more
doaj   +1 more source

Ultra-peripheral collisions and hadronic structure

, 2017
Ultra-peripheral collisions are the energy frontier for photon-mediated interactions, reaching, at the Large Hadron Collider (LHC), $\gamma-p$ center of mass energies five to ten times higher than at HERA and reaching $\gamma\gamma$ energies higher than ...
Klein, Spencer R.
core   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Management of massive peripheral ossifying fibroma using diode laser

Journal of Indian Society of Periodontology, 2019
Peripheral ossifying fibroma (POF) represents a non-neoplastic, reactive lesion of gingiva. The precise etiopathogenesis of POF is unclear; however, it is suggested to originate from the connective tissue of periodontal ligament.
Ruchi Gulati, Shaleen Khetarpal, Madhu Singh Ratre, Mishthu Solanki   +3 more
doaj   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Communications Between Peripheral and the Brain-Resident Immune System in Neuronal Regeneration After Stroke

Frontiers in Immunology, 2020
Cerebral ischemia may cause irreversible neural network damage and result in functional deficits. Targeting neuronal repair after stroke potentiates the formation of new connections, which can be translated into a better functional outcome.
Fangxi Liu, Xi Cheng, Shanshan Zhong, Chang Liu, Jukka Jolkkonen, Xiuchun Zhang, Yifan Liang, Zhouyang Liu, Chuansheng Zhao, Chuansheng Zhao   +9 more
doaj   +1 more source

Detection of Core-Periphery Structure in Networks Using Spectral Methods and Geodesic Paths

, 2016
We introduce several novel and computationally efficient methods for detecting "core--periphery structure" in networks. Core--periphery structure is a type of mesoscale structure that includes densely-connected core vertices and sparsely-connected ...
Cucuringu, Mihai, Lee, Sang Hoon, Porter, Mason A., Rombach, Puck   +3 more
core   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Hot Topics in Ultra-Peripheral Collisions

, 2002
Ultra-peripheral collisions of relativistic heavy ions involve long-ranged electromagnetic interactions at impact parameters too large for hadronic interactions to occur.
Baur, G., Bertulani, C. A., Chiu, M., Ginzburg, I. F., Hencken, K., Klein, S. R., Nystrand, J., Piotrzkowski, K., Roldao, C. G., Silvermyr, D., Thomas, J. H., White, S. N., Yepes, P.   +12 more
core   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source