Results 31 to 40 of about 4,841,252 (345)

Regulation of peripheral inflammation by spinal p38 MAP kinase in rats. [PDF]

, 2006
BackgroundSomatic afferent input to the spinal cord from a peripheral inflammatory site can modulate the peripheral response. However, the intracellular signaling mechanisms in the spinal cord that regulate this linkage have not been defined.
Albani, Salvatore, Boyle, David L, Firestein, Gary S, Hammaker, Deepa, Jones, Toni L, Rosengren, Sanna, Sorkin, Linda, Svensson, Camille I   +7 more
core   +3 more sources

Evaluation of the Induction of Immune Memory following Infant Immunisation with Serogroup C Neisseria meningitidis Conjugate Vaccines - Exploratory Analyses within a Randomised Controlled Trial [PDF]

, 2014
Aim: We measured meningococcal serogroup C (MenC)-specific memory B-cell responses in infants by Enzyme-Linked Immunospot (ELISpot) following different MenC conjugate vaccine schedules to investigate the impact of priming on immune memory.
Birks, Jacqueline, Clutterbuck, Elizabeth A., Khatami, Ameneh, McKenna, Jennifer A., Pace, David, Pollard, Andrew J., Snape, Matthew D., Thompson, Amber J.   +7 more
core   +5 more sources

Adverse reactions of amiodarone [PDF]

, 2019
Adverse drug reaction is defined by the World Health Organization as any response to a drug that is noxious and unintended and occurs at a dose normally used in man.
Calvosa, Leonardo, Ciacciarelli, Marco, Colunga Biancatelli, Ruben Ml, Congedo, Viviana, Iuliano, Luigi, Polidoro, Alessandro   +5 more
core   +1 more source

Influence of target dose heterogeneity on dose sparing of normal tissue in peripheral lung tumor stereotactic body radiation therapy

Radiation Oncology, 2021
Objective To evaluate the influence of target dose heterogeneity on normal tissue dose sparing for peripheral lung tumor stereotactic body radiation therapy (SBRT).
Zhigong Wei, Xingchen Peng, Yan Wang, Lianlian Yang, Ling He, Zheran Liu, Jingjing Wang, Xiaoli Mu, Ruidan Li, Jianghong Xiao   +9 more
doaj   +1 more source

Dose-dependent effects of chronic alcohol drinking on peripheral immune responses

Scientific Reports, 2019
It is well established that chronic heavy alcohol drinking (CHD) results in significant organ damage, increased susceptibility to infections, and poor outcomes following injury.
Suhas Sureshchandra, Anthony M. Raus, Allen Jankeel, Brian Jin Kee Ligh, N. Walter, N. Newman, K. Grant, I. Messaoudi   +7 more
semanticscholar   +1 more source

Discovery and implementation of transcriptional biomarkers of synthetic LXR agonists in peripheral blood cells

Journal of Translational Medicine, 2008
Background LXRs (Liver X Receptor α and β) are nuclear receptors that act as ligand-activated transcription factors. LXR activation causes upregulation of genes involved in reverse cholesterol transport (RCT), including ABCA1 and ABCG1 transporters, in ...
Mounts William M, Wang Shuguang, Savio Dawn, Nambi Ponnal, Liu Qiang-Yuan, Halpern Anita R, Feingold Irene, Chen Liang, Basso Michael D, Kornaga Tad, Evans Mark J, Quinet Elaine M, Arai Maya, DiBlasio-Smith Elizabeth A, Isler Jennifer A, Slager Anna M, Burczynski Michael E, Dorner Andrew J, LaVallie Edward R   +18 more
doaj   +1 more source

The effects of splenic irradiation on lymphocyte subpopulations in chronic B-lymphocytic leukemia [PDF]

, 1988
We describe the effect of splenic irradiation (SI) (0,5–1 Gy weekly) on lymphocyte subpopulations for 7 patients with progressive B chronic B-lymphocytic leukemia (B-CLL).
Aabo, Anderson, Boumsell, Byhardt, Catovsky, Durum, Enno, Foa, Foa, Herrman, Horning, Johnson, Markey, Martin, McCann, Mills, Mittelman, Paule, Platsoucas, Roncadin, Rovston, Spivak, Terstappen, Terstappen, Vann   +24 more
core   +3 more sources

Predictive value of hematological and phenotypical parameters on postchemotherapy leukocyte recovery [PDF]

, 2009
Background: Grade IV chemotherapy toxicity is defined as absolute neutrophil count <500/μL. The nadir is considered as the lowest neutrophil number following chemotherapy, and generally is not expected before the 7th day from the start of chemotherapy.
Abbasciano V, Albertini F, Barile C, Bononi A, CAMPIONI, Diana, Crepaldi G, Ferrari L, Ferrazzi E, Gilli G, Gusella M, Lanza F, Menon D, Pasini F., Russo A, Stievano L, Toso S   +15 more
core   +1 more source

Pharmacological augmentation of nicotinamide phosphoribosyltransferase (NAMPT) protects against paclitaxel-induced peripheral neuropathy

eLife, 2017
Chemotherapy-induced peripheral neuropathy (CIPN) arises from collateral damage to peripheral afferent sensory neurons by anticancer pharmacotherapy, leading to debilitating neuropathic pain.
Peter M LoCoco, April L Risinger, Hudson R Smith, Teresa S Chavera, Kelly A Berg, William P Clarke   +5 more
doaj   +1 more source

Long-term study of the impact of methotrexate on serum cytokines and lymphocyte subsets in patients with active rheumatoid arthritis: correlation with pharmacokinetic measures [PDF]

, 2016
Objective To describe changes in immune parameters observed during long-term methotrexate (MTX) therapy in patients with active rheumatoid arthritis (RA) and explore correlations with simultaneously measured MTX pharmacokinetic (PKC) parameters ...
Hamilton, Robert, Kremer, Joel M., Lawrence, David A., McInnes, Iain B.   +3 more
core   +1 more source