Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Consequences of peripheral chemoreflex inhibition with low‐dose dopamine in humans
The Journal of Physiology, 2014 Key points Low‐dose dopamine reduces the ventilatory response to acute hypoxia both in animal and in human studies. In this study we show that low‐dose dopamine ...
Niewinski, Piotr +4 more
openaire +5 more sources
Effects of Low Dose Neutron-Gamma Field on Cell Cycle and Damage of Human Lymphocytes
Dose-ResponsePurpose: The aim is to investigate the response of peripheral blood lymphocytes to a low-dose neutron-gamma field. Methods: The human peripheral blood was exposed to low-dose neutron-gamma radiation ex vivo.
Jinghong Fu +5 more
doaj +1 more source
EVALUATION OF THE INFLUENCE OF THE DRUG «CARNITIN» ON THE PERIPHERAL BLOOD
Современная наука и инновации, 2022 In the article results of experimental researches of influence of carnatine in the peripheral blood. Cherniatyn (acetyl-L-carnitine) - metabolic drugs, protecting brain tissue from ischemia; slows the aging process.
Elena Olegovna Sergeeva +4 more
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An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Is a High Dose of Vitamin D Useful for Peripheral Arterial Disease? [PDF]
European Journal of Vascular and Endovascular Surgery, 2013 n ...
Vasco, M., Paolillo, R., Napoli, C.
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Local FLASH radiation exhibits a double-edged effect on the mouse immune system
Radiation OncologyPurpose/objective(s) This study aims to investigate the impact of partial blood volume FLASH irradiation on immune system in a mouse leg model. Materials/methods The right hind limbs of C57BL/6 N mice were irradiated in a single fraction with an electron
Xiaohang Qin +10 more
doaj +1 more source
Ghrelin-induced orexigenic effect in rats depends on the metabolic status and is counteracted by peripheral CB1 receptor antagonism. [PDF]
PLoS ONE, 2013 Ghrelin is an endogenous regulator of energy homeostasis synthesized by the stomach to stimulate appetite and positive energy balance. Similarly, the endocannabinoid system is part of our internal machinery controlling food intake and energy expenditure.
Francisco Alen +7 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
MCNP Simulating the Apatial Dose Field of Cobalt-60 Irradiation Facility
Journal of Isotopes, 2022 The Monte Carlo particle transport code program MCNP is used to establish a cobalt-60 irradiation device model and simulate the peripheral spatial dose field distribution outside the irradiation station in the irradiation room.
ZENG Diming;GU Jun;SONG Yanchao
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