Results 71 to 80 of about 2,424,442 (276)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Limitations of the minimum peripheral dose as a parameter for dose specification in permanent 125I prostate implants

International Journal of Radiation Oncology*Biology*Physics, 1996
The objective of this work is to investigate whether the minimum peripheral dose is a practical parameter for dose specification in permanent 125I implants of the prostate.The investigation was carried out by use of a computer model of ellipsoidal 125I implants in which the average dimension and elongation factor were varied to provide a wide range of ...
Y, Yu, F M, Waterman, N, Suntharalingam, A, Schulsinger   +3 more
openaire   +2 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

High-dose atorvastatin is superior to moderate-dose simvastatin in preventing peripheral arterial disease

Heart, 2015
Objectives To study whether high-dose versus usual-dose statin treatment reduces the incidence of peripheral artery disease (PAD) and what is the effect of high-dose statin treatment on cardiovascular disease (CVD) outcome in patients with PAD. Methods and results
Stoekenbroek, Robert M., Boekholdt, S. Matthijs, Fayyad, Rana, Laskey, Rachel, Tikkanen, Matti J., Pedersen, Terje R., Hovingh, G. Kees   +6 more
openaire   +3 more sources

Comparison of central, peripheral, and weighted size-specific dose in CT

Journal of X-Ray Science and Technology: Clinical Applications of Diagnosis and Therapeutics, 2020
The objective of this study is to determine X-ray dose distribution and the correlation between central, peripheral and weighted-centre peripheral doses for various phantom sizes and tube voltages in computed tomography (CT). We used phantoms developed in-house, with various water-equivalent diameters (Dw) from 8.5 up to 42.1 cm.
Anam, Choirul, Adhianto, Dwi, Sutanto, Heri, Adi, Kusworo, Ali, Mohd Hanafi, Rae, William Ian Duncombe, Fujibuchi, Toshioh, Dougherty, Geoff   +7 more
openaire   +3 more sources

Comprehensive analysis of peripheral dose in electron beam therapy with a Varian TrueBeam Linac

Radiation Medicine and Protection
Objective: To investigate the characteristics of peripheral doses outside electron-beam applicators in Varian TrueBeam linacs. Method: Peripheral doses outside the electron applicator were measured for 6-, 9- and 12-MeV beams at the maximum dose depth ...
Kapil Dev Maharaj, Mahsheed Sabet, Joshua Dass, Mounir Ibrahim, Talat Mahmood, Pejman Rowshanfarzad   +5 more
doaj   +1 more source

Oxaliplatin-induced peripheral neuropathy risk factors and management in Tunisian population

The Pan African Medical Journal, 2020
The most important limits of oxaliplatin treatment is its peripheral neurotoxicity. The aim of our study was to evaluate the oxaliplatin-induced peripheral neuropathy, its impact on treatment and its management.
Aref Zribi, Sonia Ben Nasr, Syrine Hamdi, Jihen Ayari, Sana Fendri, Mehdi Balti, Abderrazek Haddaoui   +6 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Thermomechanical engineering of water-cooled plasma-facing components in fusion reactors

, 2021
Nuclear fusion is the reaction that fuels our Sun an the other stars. Adopting fusion on Earth as an energy source for electricity production offers unique advantages, such as: virtually unlimited and widely available fuel, intrinsic safety (no chain ...
DOSE, GIACOMO
core   +1 more source

Low dose methotrexate impaired T cell transmigration through down-regulating CXCR4 expression in rheumatoid arthritis (RA)

Arthritis Research & Therapy
Background CXC chemokine CXCL12 is involved in the pathological development of rheumatoid arthritis (RA) through abnormal migration of peripheral immune cells in the joint.
Lei Ding, Daniel H. Park, Bo Gao, Lingyuan Wu, Meizhang Li, Haitham Abedelhakim, Ming Zhang   +6 more
doaj   +1 more source