Results 91 to 100 of about 1,052,864 (307)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Editorial: Out-of-field second primary cancer induction: Dosimetry and modelling

Frontiers in Oncology, 2022
Beatriz Sánchez-Nieto, Liliana Stolarczyk, Liliana Stolarczyk, Alexandru Dasu, Alexandru Dasu, Wayne D. Newhauser, Francisco Sánchez-Doblado   +6 more
doaj   +1 more source

Comparison of central, peripheral, and weighted size-specific dose in CT

Journal of X-Ray Science and Technology: Clinical Applications of Diagnosis and Therapeutics, 2020
The objective of this study is to determine X-ray dose distribution and the correlation between central, peripheral and weighted-centre peripheral doses for various phantom sizes and tube voltages in computed tomography (CT). We used phantoms developed in-house, with various water-equivalent diameters (Dw) from 8.5 up to 42.1 cm. The phantoms have one
Anam, Choirul, Adhianto, Dwi, Sutanto, Heri, Adi, Kusworo, Ali, Mohd Hanafi, Rae, William Ian Duncombe, Fujibuchi, Toshioh, Dougherty, Geoff   +7 more
openaire   +3 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Peripheral Doses Beyond Electron Applicators in Conventional C-Arm Linear Accelerators: A Systematic Literature Review

Technology in Cancer Research & Treatment
Background: This review investigates peripheral dose levels in electron beam treatments, comparing different manufacturers including Varian, Elekta, and Siemens.
Kapil Dev Maharaj BSc, MSc, Joshua Dass MPH, MHM, FRANZCR, FRACMA, Mounir Ibrahim BSc, MSc, PhD, ROCMPS, Talat Mahmood BSc, MSc, ROCMPS, Pejman Rowshanfarzad BSc, MSc, PhD   +4 more
doaj   +1 more source

Prenatal Tolerance Induction: Relationship between Cell Dose, Marrow T-Cells, Chimerism, and Tolerance

Cell Transplantation, 2008
It was reported that the dose of self-antigens can determine the consequence of deletional tolerance and donor T cells are critical for tolerance induction in mixed chimeras.
Jeng-Chang Chen M.D., Ming-Ling Chang, Shiu-Feng Huang, Pei-Yeh Chang, Marcus O. Muench, Ren-Huei Fu, Liang-Shiou Ou, Ming-Ling Kuo   +7 more
doaj   +1 more source

Genetic and Modifiable Risk Factors Contributing to Cisplatin-Induced Toxicities [PDF]

, 2019
Effective administration of traditional cytotoxic chemotherapy is often limited by off-target toxicities. This clinical dilemma is epitomized by cisplatin, a platinating agent that has potent antineoplastic activity due to its affinity for DNA and other ...
Dinh, Paul C. Jr., Dolan, M., El Charif, Omar, Travis, Lois B., Trendowski, Matthew R.   +4 more
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Initiating haemodialysis twice-weekly as part of an incremental programme may protect residual kidney function [PDF]

, 2018
© The Author(s) 2018. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.Background: Initiating twice-weekly haemodialysis (2×HD) in patients who retain significant residual kidney function (RKF) may have benefits.
Busby, Amanda D, Chandna, Humza, Farrington, Ken, Kaja Kamal, Raja Mohammed, Mawer, Laura J, Sridharan, Sivakumar, Vilar, Enric, Wellsted, David   +7 more
core   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source