Results 151 to 160 of about 1,402,576 (242)

Regenerative medicine approaches for the treatment of peripheral nerve injuries: progress and challenges. [PDF]

Regen Biomater
Yang H, Bao Q, Gu X, Cong M.
europepmc   +1 more source

ZBTB18 Dysfunction Promotes Neuropathic Pain via CHD4‐based Epigenetic Disinhibition of CLIC1 Channels in Sensory Neurons

Advanced Science, EarlyView.
In this study, we identify a novel functional role of ZBTB18 in regulating trigeminal‐mediated neuropathic pain. Nerve injury reduces ZBTB18 in trigeminal ganglion neurons, impairing CHD4/NuRD recruitment and de‐repressing Clic1. Elevated CLIC1 enhances chloride channel activity and neuronal hyperexcitability, thereby driving pain.
Shoupeng Wang, Zitong Huang, Yu Tao, Yunmei Zhang, Yufang Sun, Dongsheng Jiang, Weiwei Lu, Fuhai Ji, Gang Chen, Min Xu, Yuan Zhang, Jin Tao   +11 more
wiley   +1 more source

Types of neural guides and using nanotechnology for peripheral nerve reconstruction

, 2010
Esmaeil Biazar1, MT Khorasani2, Naser Montazeri1, Khalil Pourshamsian1, Morteza Daliri3, Mostafa Rezaei T4, Mahmoud Jabarvand B5, Ahad Khoshzaban5, Saeed Heidari K4,5, Mostafa Jafarpour6, Ziba Roviemiab71Department of Chemistry, Islamic Azad University ...
MT Khorasani, et al, Naser Montazeri, Esmaeil Biazar   +3 more
core  

Clinical efficacy and electromyographic analysis of direct current hydrotherapy in the treatment of upper limb peripheral nerve injuries: A randomized controlled trial. [PDF]

J Int Med Res
Gao F, Yang Q.
europepmc   +1 more source

Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma

Advanced Science, EarlyView.
This review evaluates nanoparticle‐based phototherapies for uveal melanoma, highlighting emerging strategies to enhance tumor targeting, light delivery, and treatment precision. Preclinical data indicate improved efficacy and reduced toxicity, supporting their potential to enhance localized treatment and future translational advances. (Generated by the
Emilie Lambert, Christophe Nguyen, Sean Edward Dunn, Magali Gary‐Bobo, Jérôme Lacombe, Justin Moser, Frédéric Zenhausern, Jean‐Olivier Durand, Frédérique Cunin   +8 more
wiley   +1 more source

Exploration of rehabilitation psychology in multidisciplinary care of upper extremity peripheral nerve injuries: patient and provider perspectives. [PDF]

Front Rehabil Sci
Vu SH, Dolezal ML, Katt S, Uh J, Grannan BL, Smith SM, Crowe CS, Liu YK, Friedrich JB.   +8 more
europepmc   +1 more source

ACSL4‐Dependent Lysosomal Lipid Peroxidation Links WTAP‐Mediated m6A Modification to Intervertebral Disc Degeneration

Advanced Science, EarlyView.
IL‐1β upregulates the protein level of WTAP, which promotes the m6A modification of ACSL4 mRNA in an IGF2BP2‐dependent manner, thereby enhancing its stability. The increased ACSL4 drives lipid peroxidation, leading to lysosomal membrane permeabilization (LMP) and impaired mitophagy, which collectively accelerate intervertebral disc degeneration (IVDD).
Shu Jia, Xu Gao, Laimin Zhu, Haixia Song, Jing Wu, Shang Chen, Sheng Gao, Lu Zhang, Chunyang Meng   +8 more
wiley   +1 more source

Assessing the efficacy of ultrasound-guided platelet-rich plasma on nerve regeneration and functional outcomes in forearm peripheral nerve injuries: a retrospective observational study. [PDF]

Front Neurol
Li Q, Zou C, Liu W, Zuo L, Long H, Gao W, Liu B.   +6 more
europepmc   +1 more source

Structural Basis of Shiga Toxin Neutralization by Human Antibodies Targeting Canonical Receptor‐Binding and Non‐Canonical Assembly Sites

Advanced Science, EarlyView.
Cryo‐electron microscopy structures reveal two distinct neutralization mechanisms of fully human monoclonal antibodies targeting the Shiga toxin 1a B subunit. RDS059 occludes the Gb3 receptor‐binding site, whereas RDS045 engages a lateral quaternary epitope to disrupt holotoxin assembly.
Jianting Ke, Xin Li, Xiaoli Wang, Zhaoxia Huang, Shaojie Xue, Yuyang Liu, Jing Pan, Guowei Hu, Yayu Wang, Cheng Wang, Shoudeng Chen   +10 more
wiley   +1 more source

Surgical Outcomes in Non-Transected and Partially Transected Peripheral Nerve Injuries. [PDF]

Brain Sci
Sakthiyendran NA, Morris K, Cushman CJ, Hernandez EJ, Idicula A, MacKay BJ.   +5 more
europepmc   +1 more source