Scaffolds for Peripheral Nerve Regeneration, the Importance of In Vitro and In Vivo Studies for the Development of Cell-Based Therapies and Biomaterials: State of the Art [PDF]
, 2017 Human adult peripheral nerve injuries are a high incidence clinical problem that greatly affects patients’ quality of life. Although peripheral nervous system has intrinsic regenerative capacity, this occurs in an incomplete or poorly functional manner ...
Caseiro, Ana Rita +3 more
core +2 more sources
Somatic Nerve Reconstruction and Reinnervation [PDF]
, 2020 Somatic nerves include somatic sensory and somatic motor, both of which are part of the peripheral nervous system. When somatic motor nerve or somatosensory nerve produces injury, then it belongs to peripheral nerve injury.
Wang, Ping, Yang, Lin
core +2 more sources
Spotlight on nerves: Portable multispectral optoacoustic imaging of peripheral nerve vascularization and morphology [PDF]
arXiv, 2022 Various morphological and functional parameters of peripheral nerves and their vascular supply are indicative of pathological changes due to injury or disease. Based on recent improvements in optoacoustic image quality, we explore the ability of multispectral optoacoustic tomography, in tandem with ultrasound imaging (OPUS), to investigate the vascular
arxiv
Electro-mechanical response of a 3D nerve bundle model to mechanical loads leading to axonal injury [PDF]
International Journal for Numerical Methods in Biomedical
Engineering, 34 (2018) e2942, 2020 Objective: Traumatic brain injuries and damage are major causes of death and disability. We propose a 3D fully coupled electro-mechanical model of a nerve bundle to investigate the electrophysiological impairments due to trauma at the cellular level. Methods: The coupling is based on a thermal analogy of the neural electrical activity by using the ...
arxiv +1 more source
Unresolved excess accumulation of myelin-derived cholesterol contributes to scar formation after spinal cord injury [PDF]
arXiv, 2022 Background: Spinal cord injury triggers complex pathological cascades, resulting in destructive tissue damage and incomplete tissue repair. Scar formation is generally considered as a barrier for regeneration in central nervous system (CNS), while the intrinsic mechanism of scar-forming after spinal cord injury has not been completed deciphered ...
arxiv
Fundamentals and current strategies for Peripheral Nerve Repair and Regeneration [PDF]
, 2020 A body of evidence indicates that peripheral nerves have an extraordinary yet limited capacity to regenerate after an injury. Peripheral nerve injuries have confounded professionals in this field, from neuroscientists to neurologists, plastic surgeons ...
Carvalho, Cristiana Rodrigues +2 more
core +1 more source
Neural Regeneration Research, 2015 We performed a 2-year follow-up survey of 523 patients with peripheral nerve injuries caused by the earthquake in Wenchuan, Sichuan Province, China. Nerve injuries were classified into three types: type I injuries were nerve transection injuries, type II
Chun-qing He +3 more
doaj +1 more source
Novel Advancements in Three-Dimensional Neural Tissue Engineering and Regenerative Medicine [PDF]
Neural Regen. Res. 2015;10(3):352-4, 2015 Neurological diseases and injuries present some of the greatest challenges in modern medicine, often causing irreversible and lifelong burdens in the people whom they afflict. These diagnoses have devastating consequences on millions of people each year, and yet there are currently no therapies or interventions that can repair the structure of neural ...
arxiv +1 more source
Challenges for nerve repair using chitosan-siloxane hybrid porous scaffolds [PDF]
, 2014 The treatment of peripheral nerve injuries remains one of the greatest challenges of neurosurgery, as functional recover is rarely satisfactory in these patients.
Geuna, Stefano +6 more
core +3 more sources
Neural Regeneration Research, 2020 The peripheral nerve injuries, representing some of the most common types of traumatic lesions affecting the nervous system, are highly invalidating for the patients besides being a huge social burden.
Alessandra Pisciotta +5 more
doaj +1 more source