Results 61 to 70 of about 337,673 (396)

Micro-nanofiber composite biomimetic conduits promote long-gap peripheral nerve regeneration in canine models

Bioactive Materials, 2023
Peripheral nerve injuries may result in severe long-gap interruptions that are challenging to repair. Autografting is the gold standard surgical approach for repairing long-gap nerve injuries but can result in prominent donor-site complications. Instead,
Xianhao Dong, Yueyue Yang, Zheheng Bao, Adam C. Midgley, Feiyi Li, Shuxin Dai, Zhuangzhuang Yang, Jin Wang, Lihua Liu, Wenlei Li, Yayuan Zheng, Siyang Liu, Yang Liu, Weijian Yu, Jun Liu, Meng Fan, Meifeng Zhu, Zhongyang Shen, Gu Xiaosong, Deling Kong   +19 more
doaj   +1 more source

Multipotent vascular stem cells contribute to neurovascular regeneration of peripheral nerve. [PDF]

, 2019
BackgroundNeurovascular unit restoration is crucial for nerve regeneration, especially in critical gaps of injured peripheral nerve. Multipotent vascular stem cells (MVSCs) harvested from an adult blood vessel are involved in vascular remodeling; however,
Hsueh, Yuan-Yu, Huang, Ching-Wen, Huang, Wen-Chin, Li, Song, Patel, Shyam   +4 more
core  

Visualizing peripheral nerve regeneration by whole mount staining. [PDF]

, 2015
Peripheral nerve trauma triggers a well characterised sequence of events both proximal and distal to the site of injury. Axons distal to the injury degenerate, Schwann cells convert to a repair supportive phenotype and macrophages enter the nerve to ...
A Erturk, A Hayashi, C Witzel, D Levy, D McDonald, D Triolo, David B. Parkinson, DP Yang, DW Zochodne, DW Zochodne, G Feng, G Stoll, H Hama, I Allodi, J Lau, JW Fawcett, LL Rong, ME Vargas, MW Klymkowsky, MW Painter, N Abe, N Kiguchi, PJ Arthur-Farraj, QT Nguyen, R Martini, S Chen, S Parrinello, Simone Di Giovanni, TM Brushart, W Bruck, Xin-peng Dun, YY Chen   +31 more
core   +3 more sources

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Peripheral Nerve Regeneration Using Different Germ Layer-Derived Adult Stem Cells in the Past Decade

Behavioural Neurology, 2021
Peripheral nerve injuries (PNIs) are some of the most common types of traumatic lesions affecting the nervous system. Although the peripheral nervous system has a higher regenerative ability than the central nervous system, delayed treatment is ...
Yu Li, Yuzuru Kamei, Miki Kambe, Katsumi Ebisawa, Mayumi Oishi, Keisuke Takanari   +5 more
doaj   +1 more source

Simultaneous submicrometric 3D imaging of the micro-vascular network and the neuronal system in a mouse spinal cord [PDF]

, 2014
Defaults in vascular (VN) and neuronal networks of spinal cord are responsible for serious neurodegenerative pathologies. Because of inadequate investigation tools, the lacking knowledge of the complete fine structure of VN and neuronal systems is a ...
Battaglia, Giuseppe, Bravin, Alberto, Brun, Francesco, Bucci, Domenico, Bukreeva, Inna, Campi, Gaetano, Cedola, Alessia, Fratini, Michela, Giove, Federico, Mastrogiacomo, Maddalena, Modregger, Peter, Requardt, Herwig, Spadon, Raffaele, Tromba, Giuliana   +13 more
core   +3 more sources

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Micro-neurorrhaphy In peripheral Nerve injuries

Indian Journal of Plastic Surgery, 1991
Results of Repair under magnification, of 30 cases of peripheral nerve injuries of different nerves at different site, are presented. Success rate of the repair depends upon the meticulous care taken during surgery.
Prof. F.M. Tripathi, Dr. R.S. Kesari, Dr. A.K. Rai, Dr. U. Prakash, Prof. S. Mishra   +4 more
doaj   +1 more source

Temporal changes in the expression of the translocator protein TSPO and the steroidogenic enzyme 5a-reductase in the dorsal spinal cord of animals with neuropathic pain: effects of progesterone administration [PDF]

, 2016
Neuropathic pain is a frequent complication of spinal cord injury (SCI), still refractory to conventional treatment. The presence and biological activity of steroidogenic regulatory proteins and enzymes in the spinal cord suggests that neurosteroids ...
Adler, Natalia Sol, Coronel, Maria Florencia, de Nicola, Alejandro Federico, Gonzalez, Susana Laura, Labombarda, Maria Florencia, Raggio, María Celeste, Sánchez Granel, María Luz   +6 more
core   +2 more sources

Traumatic injury to peripheral nerves

Muscle & Nerve, 2000
AbstractThis article reviews the epidemiology, classification, localization, prognosis, and mechanisms of recovery of traumatic peripheral nerve injuries (PNIs). Electrodiagnostic (EDx) assessments are critical components of treating patients with PNIs.
openaire   +6 more sources