Results 41 to 50 of about 118,069 (298)

Autophagy-targeting modulation to promote peripheral nerve regeneration

Neural Regeneration Research
Nerve regeneration following traumatic peripheral nerve injuries and neuropathies is a complex process modulated by diverse factors and intricate molecular mechanisms.
Yan Chen, Hongxia Deng, Nannan Zhang
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Multipotent vascular stem cells contribute to neurovascular regeneration of peripheral nerve. [PDF]

, 2019
BackgroundNeurovascular unit restoration is crucial for nerve regeneration, especially in critical gaps of injured peripheral nerve. Multipotent vascular stem cells (MVSCs) harvested from an adult blood vessel are involved in vascular remodeling; however,
Hsueh, Yuan-Yu, Huang, Ching-Wen, Huang, Wen-Chin, Li, Song, Patel, Shyam   +4 more
core  

Contemporary views on inflammatory pain mechanisms: TRPing over innate and microglial pathways. [PDF]

, 2016
Tissue injury, whether by trauma, surgical intervention, metabolic dysfunction, ischemia, or infection, evokes a complex cellular response (inflammation) that is associated with painful hyperalgesic states.
Guan, Zhonghui, Hellman, Judith, Schumacher, Mark   +2 more
core   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Effects of acute fatigue on the volitional and magnetically-evoked electromechanical delay of the knee flexors in males and females [PDF]

, 2007
Neuromuscular performance capabilities, including those measured by evoked responses, may be adversely affected by fatigue; however, the capability of the neuromuscular system to initiate muscle force rapidly under these circumstances is yet to be ...
AJ McComas, AYF Chan, BD Beynnon, BR Mandelbaum, C Minshull, Claire Minshull, D Chu, David Rees, DE Rassier, E Arendt, EM Wojtys, FH Fu, H Johansson, I Tsuji, I Vivodtzev, J Gray, JT Hopkins, K Sahlin, LJ Huston, M Solomonow, M Solomonow, MA Moore, MI Polkey, Michelle Walters-Edwards, MJ Ireland, ML Latash, Nigel Gleeson, NP Gleeson, NP Gleeson, NP Gleeson, P Sbriccoli, PR Cavanagh, PV Komi, RM Norman, Roger Eston, S Zhou, S Zhou, S Zhou, S Zhou, SJ Shultz, T Horita, TH Mercer, V Strojnik   +42 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Micro-neurorrhaphy In peripheral Nerve injuries

Indian Journal of Plastic Surgery, 1991
Results of Repair under magnification, of 30 cases of peripheral nerve injuries of different nerves at different site, are presented. Success rate of the repair depends upon the meticulous care taken during surgery.
Prof. F.M. Tripathi, Dr. R.S. Kesari, Dr. A.K. Rai, Dr. U. Prakash, Prof. S. Mishra   +4 more
doaj   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Peripheral Nerve Injury to the Lower Limb: Repair and Secondary Reconstruction

Indian Journal of Plastic Surgery, 2019
This article is based on literature review of relevant articles as well as the authors’ own experiences in treating peripheral nerve injuries of the lower limb.
Mukund R. Thatte, Amita Hiremath, Mayur S. Goklani, Neehar R. Patel, Anupam B. Takwale   +4 more
doaj   +1 more source