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The Peripheral Nervous System and the Pathogenesis of Prion Diseases [PDF]

open access: greenCurrent Molecular Medicine, 2004
Prion diseases are inevitably fatal neurodegenerative conditions which affect humans and a wide variety of animals. Unlike other protein aggregation diseases such as Alzheimer's, Parkinson's, and polyglutamine repeat diseases, prion diseases are unique in that they are transmissible.
Markus Glatzel   +3 more
openalex   +5 more sources

Peripherin is a biomarker of axonal damage in peripheral nervous system disease

open access: hybridBrain, 2023
Abstract Valid, responsive blood biomarkers specific to peripheral nerve damage would improve management of peripheral nervous system (PNS) diseases. Neurofilament light chain (NfL) is sensitive for detecting axonal pathology but is not specific to PNS damage, as it is expressed throughout the PNS and CNS.
Stephen Keddie   +15 more
openalex   +5 more sources

Impact of intestinal disorders on central and peripheral nervous system diseases

open access: yesNeurobiology of Disease, 2022
Brain injuries and neurological diseases have a significant impact on the gut microbiome and the gut barrier. Reciprocally, gut disorders, such as Inflammatory Bowel Syndromes (IBS), can affect the development and pathology of neurodegenerative and neuropsychiatric diseases, although this aspect is less well studied and is the focus of this review ...
Yumna El-Hakim   +3 more
openaire   +4 more sources

Peripheral nervous system involvement in patients with sickle cell disease [PDF]

open access: bronzeEuropean Journal of Neurology, 2009
Peripheral nervous system involvement is rare in sickle cell disease (SCD). The aim of this study is to determine the peripheral nerve involvement electrophysiologically in SCD patients without clinically evident neurological signs, symptoms and to determine the relationship between the frequency of sickle cell crisis and peripheral neuropathy.Fifty ...
Esra Okuyucu   +5 more
openalex   +3 more sources

The spleen: a hub connecting nervous and immune systems in cardiovascular and metabolic diseases [PDF]

open access: yes, 2017
Metabolic disorders have been identified as major health problems affecting a large portion of the world population. In addition, obesity and insulin resistance are principal risk factors for the development of cardiovascular diseases.
Carnevale, Daniela   +3 more
core   +8 more sources

Preliminary Insights into JWH182: a Synthetic Cannabinoid’s Neuroprotective Role Against Paclitaxel-Induced Neuronal Toxicity

open access: yesInternational Journal of Medical Students, 2023
BACKGROUND: Chemotherapy-induced peripheral neuropathy (CIPN), a frequently encountered consequence of neurotoxic chemotherapy, affects approximately 30 to 40% of patients.
Mălina Maria Cernătescu   +2 more
doaj   +1 more source

Biochemical Biomarkers and Neurodegenerative Diseases

open access: yesBrain Sciences, 2021
Neurodegenerative diseases (ND) are a heterogeneous group of disorders characterized by progressive dysfunction and loss of neurons in different areas of the central nervous system or peripheral nervous system [...]
Marcello Ciaccio
doaj   +1 more source

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