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The Peripheral Nervous System and the Pathogenesis of Prion Diseases [PDF]
Current Molecular Medicine, 2004 Prion diseases are inevitably fatal neurodegenerative conditions which affect humans and a wide variety of animals. Unlike other protein aggregation diseases such as Alzheimer's, Parkinson's, and polyglutamine repeat diseases, prion diseases are unique in that they are transmissible.
Markus Glatzel +3 more
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Peripherin is a biomarker of axonal damage in peripheral nervous system disease
Brain, 2023 Abstract Valid, responsive blood biomarkers specific to peripheral nerve damage would improve management of peripheral nervous system (PNS) diseases. Neurofilament light chain (NfL) is sensitive for detecting axonal pathology but is not specific to PNS damage, as it is expressed throughout the PNS and CNS.
Stephen Keddie +15 more
openalex +5 more sources
Impact of intestinal disorders on central and peripheral nervous system diseases
Neurobiology of Disease, 2022 Brain injuries and neurological diseases have a significant impact on the gut microbiome and the gut barrier. Reciprocally, gut disorders, such as Inflammatory Bowel Syndromes (IBS), can affect the development and pathology of neurodegenerative and ...
Yumna El-Hakim +3 more
doaj +3 more sources
The Role and Mechanism of Metformin in the Treatment of Nervous System Diseases [PDF]
BiomoleculesNervous system diseases represent a significant global burden, affecting approximately 16% of the world’s population and leading to disability and mortality.
Hui Li, Ruhui Liu, Junyan Liu, Yi Qu
doaj +2 more sources
A review on recent advances on nobiletin in central and peripheral nervous system diseases [PDF]
Eur J Med Res, 2023 Yueshan Pang +3 more
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Peripheral nervous system involvement in patients with sickle cell disease [PDF]
European Journal of Neurology, 2009 Peripheral nervous system involvement is rare in sickle cell disease (SCD). The aim of this study is to determine the peripheral nerve involvement electrophysiologically in SCD patients without clinically evident neurological signs, symptoms and to determine the relationship between the frequency of sickle cell crisis and peripheral neuropathy.Fifty ...
Esra Okuyucu +5 more
openalex +3 more sources
Primary extranodal diffuse large B‐cell lymphoma: Molecular features, treatment, and prognosis
Aging and Cancer, Volume 3, Issue 3-4, Page 133-146, September-December 2022., 2022 One‐third of DLBCL arises from extranodal organs and is challenging to manage. Molecular features are critical to elucidate the differences in clinical features, predict the disease prognosis, and improve effective targeted therapeutic strategies. Abstract Diffuse large B‐cell lymphoma (DLBCL) is the most common subtype of non‐Hodgkin's lymphoma and ...
Si‐Yuan Chen +3 more
wiley +1 more source
International Journal of Medical Students, 2023 BACKGROUND: Chemotherapy-induced peripheral neuropathy (CIPN), a frequently encountered consequence of neurotoxic chemotherapy, affects approximately 30 to 40% of patients.
Mălina Maria Cernătescu +2 more
doaj +1 more source
The clinical spectrum of SMA‐PME and in vitro normalization of its cellular ceramide profile
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1941-1952, December 2022., 2022 Abstract Objective The objectives of this study were to define the clinical and biochemical spectrum of spinal muscular atrophy with progressive myoclonic epilepsy (SMA‐PME) and to determine if aberrant cellular ceramide accumulation could be normalized by enzyme replacement.
Michelle M. Lee +16 more
wiley +1 more source
Biofabrication for neural tissue engineering applications [PDF]
Materials Today Bio Volume 6, March 2020, 100043, 2022 Unlike other tissue types, the nervous tissue extends to a wide and complex environment that provides a plurality of different biochemical and topological stimuli which in turn define the functions of that tissue. As a consequence of such complexity, the traditional transplantation therapeutic methods are quite ineffective; therefore, the restoration ...
arxiv +1 more source