Results 71 to 80 of about 75,264 (232)

Malignant peripheral nerve sheath tumor of the left sciatic nerve

Archivo Médico de Camagüey, 2019
Background: malignant peripheral nerve sheath tumors are soft tissue sarcomas with a low incidence. Objective: to present a case of malignant peripheral nerve sheath tumor of the left sciatic nerve who underwent surgical treatment at the University ...
Erick Héctor Hernández-González, Gretel Mosquera-Betancourt, Yudenia Toledo-Cabarcos   +2 more
doaj  

Management of blastic plasmacytoid dendritic cell neoplasm: a case series from Chile

ARS Medica
Blastic plasmacytoid dendritic cell neoplasms (BPDCNs) are a rare hematologic malignancy characterized by an aggressive clinical course, short survival following chemotherapy, and poor prognosis.
Maximiliano Vergara, Mauricio Sarmiento-Maldonado, Mauricio Ocqueteau-Tacchini   +2 more
doaj   +1 more source

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

Advanced Science, EarlyView.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian   +16 more
wiley   +1 more source

A Mussel‐Inspired Bioadhesive Patch to Selectively Kill Glioblastoma Cells

Advanced Science, EarlyView.
An innovative mussel‐inspired bioadhesive patch has been developed for post‐surgical glioblastoma treatment. The patch, which adheres strongly in biological environments, releases a localized treatment. This treatment, acting via reactive oxygen species, shows specific toxicity to glioblastoma cells.
Jose Bolaños‐Cardet, Sara Pugliese, Jordi Bruna, Daniel Ruiz‐Molina, Salvio Suárez‐García, Victor J. Yuste   +5 more
wiley   +1 more source

Hydrocephalus and Pressure on Brain Stem Cause Death in Patients with Neurofibromatosis Type 2

پزشکی بالینی ابن سینا, 2014
Introduction: Neurofibromatosis type 2 is an inherited autosomal dominant syndrome, charac-terized by multiple neoplasms of the central and peripheral nervous system associated with ocular abnormalities.
Mojtaba Khazaei, Ali Akbar Rezaei, Tahereh Sabori, Elaheh Raeisi   +3 more
doaj  

rWTC‐MBTA Vaccine, Alone and Enhanced with Anti‐PD1, Elicits Immune Responses against CNS and Peripheral B‐Cell Lymphoma

Advanced Science, EarlyView.
An autologous whole‐tumor‐cell vaccine (rWTC‐MBTA) is evaluated in murine CNS lymphoma. Subcutaneous vaccination activates dendritic cells, broadens T‐cell priming, and drives lymphocyte trafficking to brain tumors, producing durable tumor control. Longitudinal bioluminescence and adoptive‐transfer assays verify CNS engagement. Combination with anti‐PD‐
Yaping Zhang, Juan Ye, Mitchell Sun, Samik Chakraborty, Alex Valenzuela, Shuran Chen, Qingfeng Xue, Wenyu Shi, Karel Pacak, Herui Wang, Zhengping Zhuang   +10 more
wiley   +1 more source

Amyloid β Instigates Cardiac Neurotrophic Signaling Impairment, Driving Alzheimer's Associated Heart Disease

Advanced Science, EarlyView.
This research identified cardiac amyloid pathology, neurotrophic factor depletion, and reduced myocardial nerve function in a transgenic model of cerebral amyloidosis (Tg2576), Aβ‐challenged cardiomyocytes, and in human AD heart tissue. These findings carry significant diagnostic and therapeutic implications, emphasizing the role of neuro‐signaling ...
Andrea Elia, Rebecca Parodi‐Rullan, Rafael Vazquez‐Torres, Ashley Carey, Huaqing Zhao, Sabzali Javadov, Silvia Fossati   +6 more
wiley   +1 more source

Tiny needles, major benefits: acupuncture in child health

BMC Pediatrics
Objective To retrospectively investigate the utilization patterns and clinical indications of acupuncture within the pediatric population in general hospitals from 2015 to 2020, including disease spectrum characteristics and relevance to pediatric ...
Xiaobin Ge, Gonglei Yue, Guangzhong Du, Xue Fang   +3 more
doaj   +1 more source

Substance P a potent prognostic indicator for canine mammary tumours- a comparative study

Journal of Veterinary and Animal Sciences
Substance P, a neurotransmitter in the central and peripheral nervous system, is considered as a biomarker of pain due to its key role in nociception. But recent researches have proved the increased expression of Substance P and its receptors in
Soumya Ramankutty, S, Anoop, Syam K. Venugopal, M. K. Narayanan, A. R. Nisha, G. Radhika   +5 more
doaj   +1 more source

Mesoscale Recovery of Microglial and Neuronal Dynamics After Craniotomy Across Wide Cortex in Transgenic Mice

Advanced Science, EarlyView.
This study employs longitudinal fluorescence imaging in transgenic mice to map post‐craniotomy cortical recovery. We identify distinct neuroimmune recovery phases: microglial structural inflammation peaks at ∼10 days, neuronal structural intensity peaks at ∼14 days and correlates with microglial activity, and functional network modularity is most ...
Guihua Xiao, Zhilei Wang, Pengchang Zheng, Jingyu Xie, Yangzhen Wang, Yun Chen, Zilin Wang, Ao Li, Minghuan Wang, Quanbo Ji, Can Gao, Di Yao, Lingbo Li, Jiangbei Cao   +13 more
wiley   +1 more source