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Annual Review of Immunology, 1992
The most efficient way to ensure self-tolerance in the T-cell repertoire is by intrathymic deletion of self-reactive clones. Antigens not present intrathymically may, however, influence the peripheral T-cell pool in various ways. They may of course activate T cells, provided that these have the correct specificity and affinity and that the antigens ...
J F, Miller, G, Morahan
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The most efficient way to ensure self-tolerance in the T-cell repertoire is by intrathymic deletion of self-reactive clones. Antigens not present intrathymically may, however, influence the peripheral T-cell pool in various ways. They may of course activate T cells, provided that these have the correct specificity and affinity and that the antigens ...
J F, Miller, G, Morahan
exaly +5 more sources
Spatiotemporal regulation of peripheral T cell tolerance
Science, 2023The incomplete removal of T cells that are reactive against self-proteins during their differentiation in the thymus requires mechanisms of tolerance that prevent their effector function within the periphery. A further challenge is imposed by the need to establish tolerance to the holobiont self, which comprises a highly complex community of commensal ...
Chrysothemis C. Brown +1 more
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Multiple levels of peripheral tolerance
Immunology Today, 1993The establishment and maintenance of self tolerance is based on multiple events in the thymus and periphery, resulting in either deletion of self-reactive T cells or induction of nonresponsiveness. Here, Bernd Arnold and colleagues propose that, depending on the tolerogenic signals, peripheral T cells can reach different levels of tolerance with regard
B, Arnold +2 more
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Peripheral tolerance in CD8+ T cells
Cytokine, 2009The establishment and maintenance of T cell tolerance to self- and non-pathogenic foreign antigens is critical for immune homeostasis. Thymic deletion of self-reactive T cells is an important component of tolerance, but it is incomplete, and does not establish tolerance to most foreign antigens.
Mathangi, Srinivasan +1 more
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Mechanisms maintaining peripheral tolerance
Nature Immunology, 2009The presentation of self-peptide-MHC complexes in the periphery to potentially autoreactive T cells that have escaped negative selection in the thymus poses an important problem to the immune system. In this review, I discuss data that reveal barriers preventing peripheral T cell recognition of self-peptide-MHC complexes, as well as the physiological ...
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1999
Neuropathies are uncommon, but serious, complications following radiation therapy. Radiation therapy of gynecologic tumors in 2410 patients resulted in lumbosacral plexopathies in only four patients (1). It was estimated that the lumbosacral plexus of those patients had received over 70 Gy given by a combination of implants and fractionated external ...
Edward Gillette +4 more
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Neuropathies are uncommon, but serious, complications following radiation therapy. Radiation therapy of gynecologic tumors in 2410 patients resulted in lumbosacral plexopathies in only four patients (1). It was estimated that the lumbosacral plexus of those patients had received over 70 Gy given by a combination of implants and fractionated external ...
Edward Gillette +4 more
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Mechanisms of peripheral T‐cell tolerance
Journal of Viral Hepatitis, 1997Summary. It is becoming increasingly clear that the control of self‐reactivity involves peripheral mechanisms that supplement thymic negative selection. It is now generally accepted that T‐cell activation depends upon both T‐cell receptor engagement and the delivery of B7‐mediated costimulation by specialized antigen presenting cells (APC).
R, Lechler, F M, Marelli-Berg
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1994
T-cell tolerance can be defined as specific unresponsiveness of T cells to a nominal antigen or to an alloantigen. In the case of the nominal antigen, the unresponsiveness is expected to be directed towards peptides derived from the protein and associated with self major histocompatibility complex (MHC) molecules.
Bernard Charpentier +3 more
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T-cell tolerance can be defined as specific unresponsiveness of T cells to a nominal antigen or to an alloantigen. In the case of the nominal antigen, the unresponsiveness is expected to be directed towards peptides derived from the protein and associated with self major histocompatibility complex (MHC) molecules.
Bernard Charpentier +3 more
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Immune mechanisms of peripheral tolerance
Nutrition Research, 1998Peripheral tolerance describes a panel of different strategies of the immune system to prevent the generation of an active immune response against usually harmless environmental proteins. T lymphocytes play an important role in the induction and maintenance of tolerance. These mechanisms operate on mature T cells in the periphery.
Harald Renz, Udo Herz
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