Results 261 to 270 of about 507,873 (296)

Maintenance of peripheral tolerance to islet antigens

Journal of Autoimmunity, 2016
Reestablishment of immune tolerance to the insulin-producing beta cells is the desired goal for type 1 diabetes (T1D) treatment and prevention. Immune tolerance to multiple islet antigens is defective in individuals with T1D, but the mechanisms involved are multifaceted and may involve loss of thymic and peripheral tolerance.
Emma E. Hamilton-Williams, Anne-Sophie Bergot, Peta L.S. Reeves, Raymond J. Steptoe   +3 more
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DCs and peripheral T cell tolerance

Seminars in Immunology, 2001
Tolerance is a state in which the immune system as a whole fails to make an active response to antigen. Three mutually exclusive mechanisms appear to account for the fate of antigen-specific peripheral T cells within a tolerant animal: maintenance of naive status, deletion after responding to antigen, and long term survival after responding to antigen,
openaire   +2 more sources

Peripheral Tolerance and Organ Specific Autoimmunity

2001
Concepts of specific immunotolerance were first introduced after the clonal selection theory gained acceptance. In early days Burnet and Lederberg formulated the simple concept that there was a fundamental difference between immature and mature, antigen-receptor bearing lymphocytes such that binding of antigen by the former would result in cell death ...
H, von Boehmer, E, Jaeckel
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Lateral Pupil Alignment Tolerance in Peripheral Refractometry

Optometry and Vision Science, 2011
To investigate the tolerance to lateral pupil misalignment in peripheral refraction compared with central refraction.A Shin-Nippon NVision-K5001 open-view auto-refractor was used to measure central and peripheral refraction (30° temporal and 30° nasal visual field) of the right eyes of 10 emmetropic and 10 myopic participants.
Cathleen, Fedtke, Klaus, Ehrmann, Arthur, Ho, Brien A, Holden   +3 more
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Levels of peripheral T cell tolerance

Transplant Immunology, 2002
The immune system is an adaptive defense system capable of specifically recognizing and eliminating an apparently limitless variety of foreign invaders. This highly specific response is provided by T and B lymphocytes. The enormous diversity of the antigen-specific receptors on these cells is generated by random rearrangement of the respective genes ...
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Dendritic cells in peripheral tolerance and immunity

APMIS, 2003
Dendritic cells capable of influencing immunity exist as functionally distinct subsets, T cell‐tolerizing and T cell‐immunizing subsets. The present paper reviews how these subsets of DCs develop, differentiate and function in vivo and in vitro at the cellular and molecular level.
Gad, Monika, Claesson, Mogens Helweg, Pedersen, Anders Elm   +2 more
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The novel mechanism of peripheral tolerance

Medical Hypotheses, 2003
The circulating pool of lymphocytes contains self- as well as non-self reactive T cells. The mature DCs present as non-self as well as self-epitopes to nai;ve T cells. To avoid autoimmunity the organism has to keep the mature DCs afar from self-specific T cells. I had proposed that the different anatomical distribution of the immature (tolerogenic) and
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PERIPHERAL TOLERANCE INDUCTION BY LYMPH NODE STROMA

2008
In this review we have highlighted the role of LNSCs in the regulation of CD8+ T cell immune responses in peripheral lymph nodes, thereby adding another layer of protection, in addition to the role of resting DCs, against autoimmunity. LNSCs have recently been implicated in the induction of peripheral CD8+ T cell tolerance due to their ability to ...
Erika D, Reynoso, Je-Wook, Lee, Shannon J, Turley   +2 more
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Peripheral tolerance

Research in Immunology, 1992
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DNA Vaccination to Overcome Peripheral Tolerance

2002
Abstract : The vaccination efficacy of DNA encoding autologous rat ErbB-2 (neu) or heterologous human ErbB-2 (Her-2) is compared in rat neu transgenic mice (BALB neuT). Cross reactivity between Her-2 and rat neu was tested initially by immunizing normal mice twice, i.m. with pEFBosGM-CSF and pCMVE2TM orpCDneuTM. E2TM and neuTM encodes the extracellular
openaire   +1 more source