Excellent Interrater Reliability for Manual Segmentation of the Medial Perirhinal Cortex [PDF]
Brain Sciences, 2023 Objective: Evaluation of interrater reliability for manual segmentation of brain structures that are affected first by neurofibrillary tau pathology in Alzheimer’s disease.
Nicolas A. Henzen +4 more
doaj +2 more sources
Endocytosis is required for consolidation of pattern-separated memories in the perirhinal cortex [PDF]
Frontiers in Systems Neuroscience, 2023 IntroductionThe ability to separate similar experiences into differentiated representations is proposed to be based on a computational process called pattern separation, and it is one of the key characteristics of episodic memory.
Dinka Piromalli Girado +4 more
doaj +2 more sources
A critical role for long-term potentiation mechanisms in the maintenance of object recognition memory in perirhinal cortex revealed by the infusion of zeta inhibitory pseudosubstrate [PDF]
Frontiers in Behavioral Neuroscience, 2022 Object recognition, the ability to discriminate between a novel and a familiar stimulus, is critically dependent upon the perirhinal cortex. Neural response reductions upon repetition of a stimulus, have been hypothesized to be the mechanism within ...
Alexandra R. Outram +3 more
doaj +2 more sources
Infusing zeta inhibitory peptide into the perirhinal cortex of rats abolishes long-term object recognition memory without affecting novel object location recognition [PDF]
Frontiers in Behavioral Neuroscience, 2022 Infusing the amnesic agent zeta inhibitory peptide (ZIP) into the dorsal hippocampus disrupts established long-term object location recognition memory without affecting object identity recognition, which likely depends on the perirhinal cortex.
Keanan Augereau +2 more
doaj +2 more sources
Male rodent perirhinal cortex, but not ventral hippocampus, inhibition induces approach bias under object-based approach-avoidance conflict [PDF]
eLife, 2023 Neural models of approach-avoidance (AA) conflict behavior and its dysfunction have focused traditionally on the hippocampus, with the assumption that this medial temporal lobe (MTL) structure plays a ubiquitous role in arbitrating AA conflict.
Sandeep S Dhawan +3 more
doaj +2 more sources
The hippocampus, prefrontal cortex, and perirhinal cortex are critical to incidental order memory. [PDF]
Behav Brain Res, 2020 Considerable research in rodents and humans indicates the hippocampus and prefrontal cortex are essential for remembering temporal relationships among stimuli, and accumulating evidence suggests the perirhinal cortex may also be involved.
Allen LM +4 more
europepmc +5 more sources
The topology of connections between rat prefrontal and temporal cortices [PDF]
Frontiers in Systems Neuroscience, 2015 Understanding the structural organisation of the prefrontal cortex (PFC) is an important step towards determining its functional organisation. Here we investigated the organisation of PFC using different neuronal tracers.
Stacey eBedwell +4 more
doaj +3 more sources
Perirhinal Cortex LTP Does Not Require Astrocyte BDNF-TrkB Signaling [PDF]
Cells, 2022 Neurons release and respond to brain-derived neurotrophic factor (BDNF) with bursts of brain activity. BDNF action is known to extend to peri-synaptic astrocytes, contributing to synaptic strengthening.
Beatrice Vignoli, Marco Canossa
doaj +2 more sources
Automated segmentation for cortical thickness of the medial perirhinal cortex [PDF]
Scientific ReportsAlzheimer’s disease (AD) is characterized by a progressive spread of neurofibrillary tangles (NFT), beginning in the medial perirhinal cortex (mPRC), advancing to the entorhinal cortex (ERC), and subsequently involving the hippocampus, lateral perirhinal
Nicolas A. Henzen +5 more
doaj +2 more sources
Chronic Stress Reduces Nectin-1 mRNA Levels and Disrupts Dendritic Spine Plasticity in the Adult Mouse Perirhinal Cortex [PDF]
Frontiers in Cellular Neuroscience, 2018 In adulthood, chronic exposure to stressful experiences disrupts synaptic plasticity and cognitive function. Previous studies have shown that perirhinal cortex-dependent object recognition memory is impaired by chronic stress. However, the stress effects
Qian Gong +8 more
doaj +2 more sources