Results 41 to 50 of about 8,228 (169)

Integrative and distinctive coding of visual and conceptual object features in the ventral visual stream

eLife, 2018
A significant body of research in cognitive neuroscience is aimed at understanding how object concepts are represented in the human brain. However, it remains unknown whether and where the visual and abstract conceptual features that define an object ...
Chris B Martin, Danielle Douglas, Rachel N Newsome, Louisa LY Man, Morgan D Barense   +4 more
doaj   +1 more source

Posterior white matter hyperintensities are associated with reduced medial temporal lobe subregional integrity and long-term memory in older adults

NeuroImage: Clinical, 2023
White matter hyperintensities are a marker of small vessel cerebrovascular disease that are strongly related to cognition in older adults. Similarly, medial temporal lobe atrophy is well-documented in aging and Alzheimer’s disease and is associated with ...
Batool Rizvi, Mithra Sathishkumar, Soyun Kim, Freddie Márquez, Steven J. Granger, Myra S. Larson, Blake A. Miranda, Martina K. Hollearn, Liv McMillan, Bin Nan, Nicholas J. Tustison, Patrick J. Lao, Adam M. Brickman, Dana Greenia, Maria M. Corrada, Claudia H. Kawas, Michael A. Yassa   +16 more
doaj   +1 more source

Pathological hippocampal–cortical hypersynchronization disrupts memory in temporal lobe epilepsy: A multimodal intracranial electroencephalographic–functional magnetic resonance imaging study

Epilepsia, EarlyView.
Abstract Objective Memory impairment is a common comorbidity in temporal lobe epilepsy (TLE) and is thought to arise from hippocampal dysfunction and disrupted interactions within a distributed memory network involving medial temporal, frontal, and parietal cortical regions.
Ruxue Gong, Xiaolong Peng, Rebecca W. Roth, Haris Rashid, William Yun, Daniel L. Drane, Leonardo Bonilha, Lisa McTeague, Ezequiel Gleichgerrcht   +8 more
wiley   +1 more source

In sight, in mind

eLife, 2018
A region of the brain called the perirhinal cortex represents both what things look like and what they mean.
Mariam Aly
doaj   +1 more source

Timing is everything: The effect of early‐life seizures on developing neuronal circuits subserving spatial memory

Epilepsia Open, EarlyView.
Abstract Spatial memory, the aspect of memory involving encoding and retrieval of information regarding one's environment and spatial orientation, is a complex biological function incorporating multiple neuronal networks. Hippocampus‐dependent spatial memory is not innate and emerges during development in both humans and rodents.
Gregory L. Holmes
wiley   +1 more source

Network Plasticity Involved in the Spread of Neural Activity Within the Rhinal Cortices as Revealed by Voltage-Sensitive Dye Imaging in Mouse Brain Slices

Frontiers in Cellular Neuroscience, 2019
The rhinal cortices, such as the perirhinal cortex (PC) and the entorhinal cortex (EC), are located within the bidirectional pathway between the neocortex and the hippocampus. Physiological studies indicate that the perirhinal transmission of neocortical
Riichi Kajiwara, Yoko Tominaga, Takashi Tominaga   +2 more
doaj   +1 more source

Age-At-Injury Influences the Glial Response to Traumatic Brain Injury in the Cortex of Male Juvenile Rats

Frontiers in Neurology, 2022
Few translational studies have examined how age-at-injury affects the glial response to traumatic brain injury (TBI). We hypothesized that rats injured at post-natal day (PND) 17 would exhibit a greater glial response, that would persist into early ...
Tabitha R. F. Green, Sean M. Murphy, J. Bryce Ortiz, J. Bryce Ortiz, Rachel K. Rowe, Rachel K. Rowe, Rachel K. Rowe   +6 more
doaj   +1 more source

The spatial learning task of Lhermitte and Signoret: Marker of bilateral hippocampal dysfunction in temporal lobe epilepsy

Epilepsia Open, EarlyView.
Abstract Objective Bilateral hippocampal compromise in temporal lobe epilepsy (TLE) substantially increases the risk of significant adverse memory outcomes following unilateral anterior temporal lobectomy and may contraindicate surgery. The Spatial Learning Task (SLT) of Lhermitte and Signoret (1972) is a simple object–location arbitrary associative ...
Andy Sitoh, David Weintrob, Jacqueline F. I. Anderson, Marie F. O'Shea, Graeme D. Jackson, Piero Perucca, Chris Tailby   +6 more
wiley   +1 more source

Convergent Projections from Perirhinal and Postrhinal Cortices Suggest a Multisensory Nature of Lateral, but Not Medial, Entorhinal Cortex

Cell Reports, 2019
Summary: The current model of the organization of the medial temporal lobe (MTL) episodic memory system assumes that two functionally different “where” and “what” pathways enter MTL as parallel parahippocampal cortex (PHC)-medial entorhinal cortex (MEC ...
Thanh P. Doan, Maria J. Lagartos-Donate, Eirik S. Nilssen, Shinya Ohara, Menno P. Witter   +4 more
doaj   +1 more source

Analysis of individualized brain–gut association networks and transcriptional patterns in major depressive disorder

Interdisciplinary Medicine, EarlyView.
Individualized brain–gut association networks suggest potential neuropathological mechanisms in MDD and MDDSI. Multilevel brain–gut association changes involving HSV‐1 and inflammation may be relevant to MDD, whereas alterations related to insulin metabolism may play a potential role in the neuropathological mechanisms of MDDSI.
Wei Wang, Baoyuan Zhu, Yuanyuan Huang, Liqin Liang, Zhaobo Li, Yunheng Diao, Minxin Guo, Heng Zhang, Jing Zhou, Fengchun Wu, Kai Wu   +10 more
wiley   +1 more source